A case of umbilical pemphigus vulgaris
A case of umbilical pemphigus vulgaris is reported. A 37-year-old female presented with a half-year history of repeated oral blood blisters and periumbilical itchy blisters. Dermatological examination revealed a demarcated annular irregular erosive surface covered with odorless white secretions on t...
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2024-11-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
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| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2024.11.008 |
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| author | ZHENG Hang XIE Yalin SUN Cuicui CHEN Wenjing LIANG Yunsheng CHEN Yongfeng |
| author_facet | ZHENG Hang XIE Yalin SUN Cuicui CHEN Wenjing LIANG Yunsheng CHEN Yongfeng |
| author_sort | ZHENG Hang |
| collection | DOAJ |
| description | A case of umbilical pemphigus vulgaris is reported. A 37-year-old female presented with a half-year history of repeated oral blood blisters and periumbilical itchy blisters. Dermatological examination revealed a demarcated annular irregular erosive surface covered with odorless white secretions on the umbilical area. But neither blisters nor erosions were observed in the oral mucosa. PDAI activity scores were 2 points. Pathological examination of skin lesion showed blisters in the basal layer and acantholytic cells in the epidermis, and lymphocytic infiltrations in the superficial dermis. Direct immunofluorescence revealed reticular deposition of IgG and C3 in the intercellular space of the spinous layer, without IgM and IgA depostion. The diagnosis was pemphigus vulgaris. Patient was treated with intramuscular injection of Methotrexate (10 mg) once, and oral methylprednisolone tablets at a dose of 24 mg once daily, in addition to calcium supplementation and topical applications of Halometasone and Sodium Fusidate Ointment. After the skin lesion was improved, the patient was discharged. No new lesions occurred during 6-month phone follow-up. |
| format | Article |
| id | doaj-art-43644ceffbbe47278061485ea5a203cf |
| institution | OA Journals |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-43644ceffbbe47278061485ea5a203cf2025-08-20T02:00:09Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682024-11-01311177377710.3969/j.issn.1674-8468.2024.11.008A case of umbilical pemphigus vulgarisZHENG Hang0XIE Yalin1SUN Cuicui2CHEN Wenjing3LIANG Yunsheng4CHEN Yongfeng5Guangdong Clinical College of Dermatology, Anhui Medical UniversityDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaGuangdong Clinical College of Dermatology, Anhui Medical UniversityDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaDermatology Hospital, Southern Medical University, Guangzhou 510091, ChinaGuangdong Clinical College of Dermatology, Anhui Medical UniversityA case of umbilical pemphigus vulgaris is reported. A 37-year-old female presented with a half-year history of repeated oral blood blisters and periumbilical itchy blisters. Dermatological examination revealed a demarcated annular irregular erosive surface covered with odorless white secretions on the umbilical area. But neither blisters nor erosions were observed in the oral mucosa. PDAI activity scores were 2 points. Pathological examination of skin lesion showed blisters in the basal layer and acantholytic cells in the epidermis, and lymphocytic infiltrations in the superficial dermis. Direct immunofluorescence revealed reticular deposition of IgG and C3 in the intercellular space of the spinous layer, without IgM and IgA depostion. The diagnosis was pemphigus vulgaris. Patient was treated with intramuscular injection of Methotrexate (10 mg) once, and oral methylprednisolone tablets at a dose of 24 mg once daily, in addition to calcium supplementation and topical applications of Halometasone and Sodium Fusidate Ointment. After the skin lesion was improved, the patient was discharged. No new lesions occurred during 6-month phone follow-up.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2024.11.008pemphigus vulgarisumbilical region |
| spellingShingle | ZHENG Hang XIE Yalin SUN Cuicui CHEN Wenjing LIANG Yunsheng CHEN Yongfeng A case of umbilical pemphigus vulgaris Pifu-xingbing zhenliaoxue zazhi pemphigus vulgaris umbilical region |
| title | A case of umbilical pemphigus vulgaris |
| title_full | A case of umbilical pemphigus vulgaris |
| title_fullStr | A case of umbilical pemphigus vulgaris |
| title_full_unstemmed | A case of umbilical pemphigus vulgaris |
| title_short | A case of umbilical pemphigus vulgaris |
| title_sort | case of umbilical pemphigus vulgaris |
| topic | pemphigus vulgaris umbilical region |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2024.11.008 |
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