Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects
Background: Periodontitis is a long-term, multifactorial inflammatory condition that is triggered by bacterial germs and interacts with the host's immune system. The unique attachment of fibrous tissue between the cementum and bone presents a challenge for periodontal regeneration. Aim: To achi...
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| Format: | Article |
| Language: | English |
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Springer
2023-09-01
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| Series: | Saudi Dental Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905223001104 |
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| author | Ahmed M. Badr Hany K. Shalaby Mohamed A. Awad Mohamed A. Hashem |
| author_facet | Ahmed M. Badr Hany K. Shalaby Mohamed A. Awad Mohamed A. Hashem |
| author_sort | Ahmed M. Badr |
| collection | DOAJ |
| description | Background: Periodontitis is a long-term, multifactorial inflammatory condition that is triggered by bacterial germs and interacts with the host's immune system. The unique attachment of fibrous tissue between the cementum and bone presents a challenge for periodontal regeneration. Aim: To achieve the lowest optimum dose of BMP-7 that helps in periodontal regeneration, involving newly formed cementum, PDL and bone Materials and methods: Five healthy mongrel dogs were used for the study. A critical class III furcation defect was created using rotating burs. The bone defects (ten defects for each group) were allocated to one of the subsequent groups: (Group 1) control with the surgical defect only. (Group 2) Surgical defect implanted with hydrogel only (CS/β-GP). (Group 3) Surgical defect implanted with CS/BMP-7 (50 ng/ml). (Group 4) Surgical defect implanted with CS/BMP-7 (100 ng/ml). Results: Histomorphometric and H&E analysis revealed a statistically significant difference in bone, PDL, and cementum regeneration defects filled with CS/BMP-7 (100 ng/ml) compared with other groups. Conclusion: The standard effective dose for BMP-7 use in periodontal regeneration is 100 ng/ml. |
| format | Article |
| id | doaj-art-4355e8fb676e48b19dcfade2c8f8fd80 |
| institution | Kabale University |
| issn | 1013-9052 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-4355e8fb676e48b19dcfade2c8f8fd802025-08-20T03:35:57ZengSpringerSaudi Dental Journal1013-90522023-09-0135676076710.1016/j.sdentj.2023.05.027Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defectsAhmed M. Badr0Hany K. Shalaby1Mohamed A. Awad2Mohamed A. Hashem3Faculty of Dentistry, Sinai University, Egypt; Corresponding author.Faculty of Dentistry, Suez University, EgyptFaculty of Dentistry, Suez Canal University, EgyptFaculty of Veterinary Medicine, Suez Canal University, EgyptBackground: Periodontitis is a long-term, multifactorial inflammatory condition that is triggered by bacterial germs and interacts with the host's immune system. The unique attachment of fibrous tissue between the cementum and bone presents a challenge for periodontal regeneration. Aim: To achieve the lowest optimum dose of BMP-7 that helps in periodontal regeneration, involving newly formed cementum, PDL and bone Materials and methods: Five healthy mongrel dogs were used for the study. A critical class III furcation defect was created using rotating burs. The bone defects (ten defects for each group) were allocated to one of the subsequent groups: (Group 1) control with the surgical defect only. (Group 2) Surgical defect implanted with hydrogel only (CS/β-GP). (Group 3) Surgical defect implanted with CS/BMP-7 (50 ng/ml). (Group 4) Surgical defect implanted with CS/BMP-7 (100 ng/ml). Results: Histomorphometric and H&E analysis revealed a statistically significant difference in bone, PDL, and cementum regeneration defects filled with CS/BMP-7 (100 ng/ml) compared with other groups. Conclusion: The standard effective dose for BMP-7 use in periodontal regeneration is 100 ng/ml.http://www.sciencedirect.com/science/article/pii/S1013905223001104BMP-7Periodontal regenerationPeriodontal ligament (PDL)Guided tissue regeneration (GTR) |
| spellingShingle | Ahmed M. Badr Hany K. Shalaby Mohamed A. Awad Mohamed A. Hashem Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects Saudi Dental Journal BMP-7 Periodontal regeneration Periodontal ligament (PDL) Guided tissue regeneration (GTR) |
| title | Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects |
| title_full | Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects |
| title_fullStr | Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects |
| title_full_unstemmed | Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects |
| title_short | Assessment of bone morphogenetic protein-7 loaded chitosan/β-Glycerophosphate hydrogel on periodontium tissues regeneration of class III furcation defects |
| title_sort | assessment of bone morphogenetic protein 7 loaded chitosan β glycerophosphate hydrogel on periodontium tissues regeneration of class iii furcation defects |
| topic | BMP-7 Periodontal regeneration Periodontal ligament (PDL) Guided tissue regeneration (GTR) |
| url | http://www.sciencedirect.com/science/article/pii/S1013905223001104 |
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