Search for the elusive haplotype of the APOE polymorphism associated with Alzheimer’s disease

Search for the elusive haplotype of the APOE polymorphism associated with Alzheimer’s disease

Abstract The common APOE2/E3/E4 polymorphism is determined by two-site haplotypes: C112R and R158C. Due to strong linkage disequilibrium (LD) between the two sites, three of the four expected haplotypes/alleles (E2, E3, E4) have been observed. Compared to the most common E3 haplotype (C112–R158), E4...

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Bibliographic Details
Main Authors: Asma Naseer Cheema, Kang-Hsien Fan, Elizabeth Lawrence, Narges Zafari, Ruyu Shi, Muhammad Muaaz Aslam, Vibha Acharya, Alayna Jean Holderman, Annie Bedison, Eleanor Feingold, M. Ilyas Kamboh
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
APOE haplotype
Cloning
Sequencing
Genotyping
Recombination, point mutation
Online Access:https://doi.org/10.1038/s41598-025-01263-0
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