Activated Microglia Mediate the Motor Neuron‐, Synaptic Denervation‐ and Muscle Wasting‐Changes in Burn Injured Mice

Activated Microglia Mediate the Motor Neuron‐, Synaptic Denervation‐ and Muscle Wasting‐Changes in Burn Injured Mice

ABSTRACT Background Muscle wasting (MW) of burn injury (BI) remains unresolved. Microglia‐mediated inflammatory cytokine/chemokine release, motor neuron loss (MNL) and MW is observed after BI but connection of the central changes to synaptic‐denervation and MW is unelucidated. Stimulation of microgl...

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Bibliographic Details
Main Authors: Jingyuan Chen, Yoshinori Kitagawa, Fei Xie, Haobo Li, William R. Kem, Zerong You, Shingo Yasuhara, J. A. Jeevendra Martyn
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
burn injury
inflammatory cytokines/chemokines
microglia activation
muscle wasting
neuronal apoptosis
Online Access:https://doi.org/10.1002/jcsm.13755
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