Associations between naples prognostic score and stroke and mortality among older adults
Abstract Background Inflammation and malnutrition in the body are closely related to the incidence of stroke. Older adults often suffer from malnutrition and inflammation. Naples Prognostic Score (NPS), a novel inflammation-malnutrition score, can effectively assess the inflammation and nutritional...
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BMC
2025-04-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02613-4 |
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| author | Junting Song Lin Yin |
| author_facet | Junting Song Lin Yin |
| author_sort | Junting Song |
| collection | DOAJ |
| description | Abstract Background Inflammation and malnutrition in the body are closely related to the incidence of stroke. Older adults often suffer from malnutrition and inflammation. Naples Prognostic Score (NPS), a novel inflammation-malnutrition score, can effectively assess the inflammation and nutritional status of the body. The aim of this study is to explore the connection between NPS and stroke among older adults, as well as the association between NPS and mortality in older adults. Methods Participants eligible for the study were collected from National Health and Nutrition Examination Survey(NHANES) data from 1999 to 2018. Logistic regression models were employed to investigate the link between NPS and stroke. Additionally, restricted cubic spline was utilized to explore the correlations. Subgroup analysis was adopted in order to ensure the credibility of the results. Kaplan–Meier Survival curve and cox regression models and were utilized to evaluate the link between NPS and mortality among older adults. Results 16,940 older adults qualified for analysis. The participants with stroke had higher levels of NPS. In the logistic regression model, NPS was positively related to stroke (high NPS vs. low NPS, OR = 1.70 (95% CI 1.24–2.35), P < 0.001). Restricted cubic spline revealed a positive non-linear relationship (P for overall < 0.001, P for non-linear < 0.001). Subgroup analysis showed that the association between NPS and the incidence of stroke is more significant in the non-diabetes population (P < 0.001). The Kaplan–Meier curve shows that patients with high NPS have a significantly higher risk of all-cause mortality and cardiovascular mortality (P < 0.001). In the Cox regression model, a positive correlation was observed between NPS and mortality among older adults (all-cause mortality: HR = 1.36 (95% CI 1.30–1.42); cardiovascular mortality:HR = 1.59 (95% CI 1.45–1.75)). Conclusions A positive link was observed between NPS and stroke and mortality. Routine NPS screening may enhance risk stratification in geriatric clinics. |
| format | Article |
| id | doaj-art-434e296d16684c0d97df5a2475b3f463 |
| institution | DOAJ |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | European Journal of Medical Research |
| spelling | doaj-art-434e296d16684c0d97df5a2475b3f4632025-08-20T03:14:05ZengBMCEuropean Journal of Medical Research2047-783X2025-04-0130111310.1186/s40001-025-02613-4Associations between naples prognostic score and stroke and mortality among older adultsJunting Song0Lin Yin1Department of Neurology, The Second Hospital of Dalian Medical UniversityDepartment of Neurology, The Second Hospital of Dalian Medical UniversityAbstract Background Inflammation and malnutrition in the body are closely related to the incidence of stroke. Older adults often suffer from malnutrition and inflammation. Naples Prognostic Score (NPS), a novel inflammation-malnutrition score, can effectively assess the inflammation and nutritional status of the body. The aim of this study is to explore the connection between NPS and stroke among older adults, as well as the association between NPS and mortality in older adults. Methods Participants eligible for the study were collected from National Health and Nutrition Examination Survey(NHANES) data from 1999 to 2018. Logistic regression models were employed to investigate the link between NPS and stroke. Additionally, restricted cubic spline was utilized to explore the correlations. Subgroup analysis was adopted in order to ensure the credibility of the results. Kaplan–Meier Survival curve and cox regression models and were utilized to evaluate the link between NPS and mortality among older adults. Results 16,940 older adults qualified for analysis. The participants with stroke had higher levels of NPS. In the logistic regression model, NPS was positively related to stroke (high NPS vs. low NPS, OR = 1.70 (95% CI 1.24–2.35), P < 0.001). Restricted cubic spline revealed a positive non-linear relationship (P for overall < 0.001, P for non-linear < 0.001). Subgroup analysis showed that the association between NPS and the incidence of stroke is more significant in the non-diabetes population (P < 0.001). The Kaplan–Meier curve shows that patients with high NPS have a significantly higher risk of all-cause mortality and cardiovascular mortality (P < 0.001). In the Cox regression model, a positive correlation was observed between NPS and mortality among older adults (all-cause mortality: HR = 1.36 (95% CI 1.30–1.42); cardiovascular mortality:HR = 1.59 (95% CI 1.45–1.75)). Conclusions A positive link was observed between NPS and stroke and mortality. Routine NPS screening may enhance risk stratification in geriatric clinics.https://doi.org/10.1186/s40001-025-02613-4Naples Prognostic ScoreNational Health and Nutrition Examination SurveyOlder adultsStrokeMortality |
| spellingShingle | Junting Song Lin Yin Associations between naples prognostic score and stroke and mortality among older adults European Journal of Medical Research Naples Prognostic Score National Health and Nutrition Examination Survey Older adults Stroke Mortality |
| title | Associations between naples prognostic score and stroke and mortality among older adults |
| title_full | Associations between naples prognostic score and stroke and mortality among older adults |
| title_fullStr | Associations between naples prognostic score and stroke and mortality among older adults |
| title_full_unstemmed | Associations between naples prognostic score and stroke and mortality among older adults |
| title_short | Associations between naples prognostic score and stroke and mortality among older adults |
| title_sort | associations between naples prognostic score and stroke and mortality among older adults |
| topic | Naples Prognostic Score National Health and Nutrition Examination Survey Older adults Stroke Mortality |
| url | https://doi.org/10.1186/s40001-025-02613-4 |
| work_keys_str_mv | AT juntingsong associationsbetweennaplesprognosticscoreandstrokeandmortalityamongolderadults AT linyin associationsbetweennaplesprognosticscoreandstrokeandmortalityamongolderadults |