Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles
Amoxicillin polybutylcyanoacrylate nanoparticles (AMX-PBCA-NP) were prepared by the emulsion polymerization method with butylcyanoacrylate (BCA) as a carrier material. The preparation procedure was optimized according to the results of single factor experiments and uniform design tests, and then the...
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| Format: | Article |
| Language: | English |
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Zhejiang University Press
2009-03-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
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| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2009.02.012 |
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| author | YANG Xue-feng OUYANG Wu-qing LIU Yu-mei ZHANG Wen-juan SUN Jiang-cai |
| author_facet | YANG Xue-feng OUYANG Wu-qing LIU Yu-mei ZHANG Wen-juan SUN Jiang-cai |
| author_sort | YANG Xue-feng |
| collection | DOAJ |
| description | Amoxicillin polybutylcyanoacrylate nanoparticles (AMX-PBCA-NP) were prepared by the emulsion polymerization method with butylcyanoacrylate (BCA) as a carrier material. The preparation procedure was optimized according to the results of single factor experiments and uniform design tests, and then the quality of AMX-PBCA-NP was evaluated. The results show that the screened optimum conditions for the preparation of AMX-PBCA-NP were 4 g·L<sup>-1</sup> amoxicillin, 10 mL·L<sup>-1</sup> BCA, 10 g·L<sup>-1</sup> pluronic F68, 10 g·L<sup>-1</sup> dextran-70 and pH 3.0. The prepared nanoparticles were globular, unconglutinate, well-distributed. The mean diameter of the particles was (222.33±1.53) nm, polydispersity index was 0.03±0.02, the mean encapsulation ratio and drug-load was (73.47±0.96)% and (29.39±0.38)%, respectively. The release characteristics in vitro were consistent with two phases kinetics rule. The minimal inhibitory concentration (MIC) against E. coli ATCC<sub>25922</sub> and S. aureus ATCC<sub>25923</sub> was 1/2 times of the MIC of active pharmaceutical ingredients, respectively. The results above suggested that the optimal preparation procedure of AMX-PBCA-NP is practicable, AMX-PBCA-NP has the slow-release character and the antibacterial activity of amoxicillin is enhanced in vitro. |
| format | Article |
| id | doaj-art-4341b149798540cca442fef89e0cc3ef |
| institution | DOAJ |
| issn | 1008-9209 2097-5155 |
| language | English |
| publishDate | 2009-03-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | 浙江大学学报. 农业与生命科学版 |
| spelling | doaj-art-4341b149798540cca442fef89e0cc3ef2025-08-20T02:47:40ZengZhejiang University Press浙江大学学报. 农业与生命科学版1008-92092097-51552009-03-013519520010.3785/j.issn.1008-9209.2009.02.01210089209Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticlesYANG Xue-fengOUYANG Wu-qingLIU Yu-meiZHANG Wen-juanSUN Jiang-caiAmoxicillin polybutylcyanoacrylate nanoparticles (AMX-PBCA-NP) were prepared by the emulsion polymerization method with butylcyanoacrylate (BCA) as a carrier material. The preparation procedure was optimized according to the results of single factor experiments and uniform design tests, and then the quality of AMX-PBCA-NP was evaluated. The results show that the screened optimum conditions for the preparation of AMX-PBCA-NP were 4 g·L<sup>-1</sup> amoxicillin, 10 mL·L<sup>-1</sup> BCA, 10 g·L<sup>-1</sup> pluronic F68, 10 g·L<sup>-1</sup> dextran-70 and pH 3.0. The prepared nanoparticles were globular, unconglutinate, well-distributed. The mean diameter of the particles was (222.33±1.53) nm, polydispersity index was 0.03±0.02, the mean encapsulation ratio and drug-load was (73.47±0.96)% and (29.39±0.38)%, respectively. The release characteristics in vitro were consistent with two phases kinetics rule. The minimal inhibitory concentration (MIC) against E. coli ATCC<sub>25922</sub> and S. aureus ATCC<sub>25923</sub> was 1/2 times of the MIC of active pharmaceutical ingredients, respectively. The results above suggested that the optimal preparation procedure of AMX-PBCA-NP is practicable, AMX-PBCA-NP has the slow-release character and the antibacterial activity of amoxicillin is enhanced in vitro.https://www.academax.com/doi/10.3785/j.issn.1008-9209.2009.02.012amoxicillinnanoparticlespolybutylcyanoacrylateuniform designquality evaluation |
| spellingShingle | YANG Xue-feng OUYANG Wu-qing LIU Yu-mei ZHANG Wen-juan SUN Jiang-cai Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles 浙江大学学报. 农业与生命科学版 amoxicillin nanoparticles polybutylcyanoacrylate uniform design quality evaluation |
| title | Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles |
| title_full | Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles |
| title_fullStr | Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles |
| title_full_unstemmed | Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles |
| title_short | Preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles |
| title_sort | preparation and quality evaluation of amoxicillin polybutylcyanoacrylate nanoparticles |
| topic | amoxicillin nanoparticles polybutylcyanoacrylate uniform design quality evaluation |
| url | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2009.02.012 |
| work_keys_str_mv | AT yangxuefeng preparationandqualityevaluationofamoxicillinpolybutylcyanoacrylatenanoparticles AT ouyangwuqing preparationandqualityevaluationofamoxicillinpolybutylcyanoacrylatenanoparticles AT liuyumei preparationandqualityevaluationofamoxicillinpolybutylcyanoacrylatenanoparticles AT zhangwenjuan preparationandqualityevaluationofamoxicillinpolybutylcyanoacrylatenanoparticles AT sunjiangcai preparationandqualityevaluationofamoxicillinpolybutylcyanoacrylatenanoparticles |