Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power Supply
We present a simple and cost-effective method for generating a dielectric barrier discharge (DBD) plasma using a commercially available ozone generator power supply. By coupling the plasma source to the extended ion transfer tube of an ambient mass spectrometer, we achieved stable plasma discharge,...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/1420-3049/30/12/2546 |
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| author | Yunshuo Tian Yifan Meng Richard N. Zare |
| author_facet | Yunshuo Tian Yifan Meng Richard N. Zare |
| author_sort | Yunshuo Tian |
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| description | We present a simple and cost-effective method for generating a dielectric barrier discharge (DBD) plasma using a commercially available ozone generator power supply. By coupling the plasma source to the extended ion transfer tube of an ambient mass spectrometer, we achieved stable plasma discharge, enabling the post-ionization of nonpolar compounds during the electrospray ionization process. Using this approach, we successfully detected polycyclic aromatic hydrocarbons (PAHs), halogenated PAHs (HPAHs), and other nonpolar pollutants in liquid mixtures, with detection limits on the order of 10 ng/mL. In fish exposed to HPAHs, both polar metabolites and lipids, as well as the nonpolar pollutant 1-chloronaphthalene, were simultaneously detected. Notably, 1-chloronaphthalene accumulated at the highest concentration in gill tissue. This straightforward plasma-assisted technique offers a reliable strategy for expanding the detection capabilities of electrospray mass spectrometry to include nonpolar molecules. |
| format | Article |
| id | doaj-art-43416de4d662445fa190e4e5455af604 |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-43416de4d662445fa190e4e5455af6042025-08-20T03:29:44ZengMDPI AGMolecules1420-30492025-06-013012254610.3390/molecules30122546Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power SupplyYunshuo Tian0Yifan Meng1Richard N. Zare2College of Letter and Science, University of California, Santa Barbara, CA 93106, USADepartment of Chemistry, Stanford University, Stanford, CA 94305, USADepartment of Chemistry, Stanford University, Stanford, CA 94305, USAWe present a simple and cost-effective method for generating a dielectric barrier discharge (DBD) plasma using a commercially available ozone generator power supply. By coupling the plasma source to the extended ion transfer tube of an ambient mass spectrometer, we achieved stable plasma discharge, enabling the post-ionization of nonpolar compounds during the electrospray ionization process. Using this approach, we successfully detected polycyclic aromatic hydrocarbons (PAHs), halogenated PAHs (HPAHs), and other nonpolar pollutants in liquid mixtures, with detection limits on the order of 10 ng/mL. In fish exposed to HPAHs, both polar metabolites and lipids, as well as the nonpolar pollutant 1-chloronaphthalene, were simultaneously detected. Notably, 1-chloronaphthalene accumulated at the highest concentration in gill tissue. This straightforward plasma-assisted technique offers a reliable strategy for expanding the detection capabilities of electrospray mass spectrometry to include nonpolar molecules.https://www.mdpi.com/1420-3049/30/12/2546ozone generator power supplydielectric barrier discharge ionizationnonpolar moleculesmass spectrometry |
| spellingShingle | Yunshuo Tian Yifan Meng Richard N. Zare Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power Supply Molecules ozone generator power supply dielectric barrier discharge ionization nonpolar molecules mass spectrometry |
| title | Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power Supply |
| title_full | Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power Supply |
| title_fullStr | Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power Supply |
| title_full_unstemmed | Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power Supply |
| title_short | Simultaneous Detection of Polar and Nonpolar Molecules by Nano-ESI MS with Plasma Ignited by an Ozone Generator Power Supply |
| title_sort | simultaneous detection of polar and nonpolar molecules by nano esi ms with plasma ignited by an ozone generator power supply |
| topic | ozone generator power supply dielectric barrier discharge ionization nonpolar molecules mass spectrometry |
| url | https://www.mdpi.com/1420-3049/30/12/2546 |
| work_keys_str_mv | AT yunshuotian simultaneousdetectionofpolarandnonpolarmoleculesbynanoesimswithplasmaignitedbyanozonegeneratorpowersupply AT yifanmeng simultaneousdetectionofpolarandnonpolarmoleculesbynanoesimswithplasmaignitedbyanozonegeneratorpowersupply AT richardnzare simultaneousdetectionofpolarandnonpolarmoleculesbynanoesimswithplasmaignitedbyanozonegeneratorpowersupply |