Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital
Abstract Background Stroke is a major neurological disorder often exacerbated by substance abuse, including tramadol and cannabis. Understanding the molecular mechanisms underlying stroke pathogenesis in drug users can improve diagnosis and treatment. This study explores the roles of CYP4A11, CYP2E1...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2024-12-01
|
| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-024-00926-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594894859796480 |
|---|---|
| author | Nashwa E. Ahmed Amina M. Nagah Omima R. Mohamed Ghada Mohamed Mahmoud Sania K. Elwia |
| author_facet | Nashwa E. Ahmed Amina M. Nagah Omima R. Mohamed Ghada Mohamed Mahmoud Sania K. Elwia |
| author_sort | Nashwa E. Ahmed |
| collection | DOAJ |
| description | Abstract Background Stroke is a major neurological disorder often exacerbated by substance abuse, including tramadol and cannabis. Understanding the molecular mechanisms underlying stroke pathogenesis in drug users can improve diagnosis and treatment. This study explores the roles of CYP4A11, CYP2E1, miR-27b, and miR-214-3p in the pathogenesis of stroke and their potential as diagnostic markers in individuals using tramadol and cannabis. Results Our findings indicate that CYP4A11 and CYP2E1 are significantly upregulated in the brain tissues of stroke patients who use tramadol and cannabis. Additionally, miR-27b and miR-214-3p levels were markedly altered, suggesting their involvement in stroke pathogenesis. The combined analysis of these biomarkers provided a robust diagnostic model with high sensitivity and specificity for identifying stroke in the context of drug addiction. Conclusions CYP4A11, CYP2E1, miR-27b, and miR-214-3p play critical roles in the pathogenesis of stroke in tramadol and cannabis users. These biomarkers hold promise as diagnostic tools, offering potential for early detection and personalized treatment strategies for stroke in drug-addicted populations. Further research is warranted to validate these findings and explore their therapeutic implications. |
| format | Article |
| id | doaj-art-4339585ed6ba475188899a4c253589bb |
| institution | Kabale University |
| issn | 1687-8329 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-4339585ed6ba475188899a4c253589bb2025-01-19T12:14:24ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292024-12-0160111010.1186/s41983-024-00926-5Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospitalNashwa E. Ahmed0Amina M. Nagah1Omima R. Mohamed2Ghada Mohamed Mahmoud3Sania K. Elwia4Medical Biochemistry & Molecular Biology Department, Faculty of Medicine, Benha UniversityNeurology Department, Faculty of Medicine, Benha UniversityForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Benha UniversityClinical and Chemical Pathology Department, Faculty of Medicine, Benha UniversityMedical Biochemistry & Molecular Biology Department, Faculty of Medicine, Benha UniversityAbstract Background Stroke is a major neurological disorder often exacerbated by substance abuse, including tramadol and cannabis. Understanding the molecular mechanisms underlying stroke pathogenesis in drug users can improve diagnosis and treatment. This study explores the roles of CYP4A11, CYP2E1, miR-27b, and miR-214-3p in the pathogenesis of stroke and their potential as diagnostic markers in individuals using tramadol and cannabis. Results Our findings indicate that CYP4A11 and CYP2E1 are significantly upregulated in the brain tissues of stroke patients who use tramadol and cannabis. Additionally, miR-27b and miR-214-3p levels were markedly altered, suggesting their involvement in stroke pathogenesis. The combined analysis of these biomarkers provided a robust diagnostic model with high sensitivity and specificity for identifying stroke in the context of drug addiction. Conclusions CYP4A11, CYP2E1, miR-27b, and miR-214-3p play critical roles in the pathogenesis of stroke in tramadol and cannabis users. These biomarkers hold promise as diagnostic tools, offering potential for early detection and personalized treatment strategies for stroke in drug-addicted populations. Further research is warranted to validate these findings and explore their therapeutic implications.https://doi.org/10.1186/s41983-024-00926-5StrokeDrud abuseCYP4A11CYP2E1miR-214-3pmiR-27b |
| spellingShingle | Nashwa E. Ahmed Amina M. Nagah Omima R. Mohamed Ghada Mohamed Mahmoud Sania K. Elwia Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Stroke Drud abuse CYP4A11 CYP2E1 miR-214-3p miR-27b |
| title | Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital |
| title_full | Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital |
| title_fullStr | Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital |
| title_full_unstemmed | Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital |
| title_short | Early peripheral blood gene expression (Cyp4A11 and Cyp2E1) in cases of brain ischemia in addict cases admitted to Benha university hospital |
| title_sort | early peripheral blood gene expression cyp4a11 and cyp2e1 in cases of brain ischemia in addict cases admitted to benha university hospital |
| topic | Stroke Drud abuse CYP4A11 CYP2E1 miR-214-3p miR-27b |
| url | https://doi.org/10.1186/s41983-024-00926-5 |
| work_keys_str_mv | AT nashwaeahmed earlyperipheralbloodgeneexpressioncyp4a11andcyp2e1incasesofbrainischemiainaddictcasesadmittedtobenhauniversityhospital AT aminamnagah earlyperipheralbloodgeneexpressioncyp4a11andcyp2e1incasesofbrainischemiainaddictcasesadmittedtobenhauniversityhospital AT omimarmohamed earlyperipheralbloodgeneexpressioncyp4a11andcyp2e1incasesofbrainischemiainaddictcasesadmittedtobenhauniversityhospital AT ghadamohamedmahmoud earlyperipheralbloodgeneexpressioncyp4a11andcyp2e1incasesofbrainischemiainaddictcasesadmittedtobenhauniversityhospital AT saniakelwia earlyperipheralbloodgeneexpressioncyp4a11andcyp2e1incasesofbrainischemiainaddictcasesadmittedtobenhauniversityhospital |