Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registry
Aim. To evaluate 24-month outcomes after hospital treatment of patients with coronavirus disease 2019 (COVID-19) in a prospective registry.Material and methods. Two-year outcomes (2,2±0,5) after hospital treatment for COVID-19 were analyzed in 802 patients (mean age, 59,8±14,5 years, men, 51,0%). We...
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| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2023-11-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3757 |
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| author | M. M. Lukyanov E. Yu. Andreenko S. Yu. Martsevich N. P. Kutishenko V. P. Voronina V. A. Dindikova N. A. Dmitrieva M. M. Kudryavtseva O. V. Lerman A. N. Makoveeva E. Yu. Okshina A. A. Pulin А. А. Smirnov V. G. Klyashtorny O. E. Karpov O. M. Drapkina |
| author_facet | M. M. Lukyanov E. Yu. Andreenko S. Yu. Martsevich N. P. Kutishenko V. P. Voronina V. A. Dindikova N. A. Dmitrieva M. M. Kudryavtseva O. V. Lerman A. N. Makoveeva E. Yu. Okshina A. A. Pulin А. А. Smirnov V. G. Klyashtorny O. E. Karpov O. M. Drapkina |
| author_sort | M. M. Lukyanov |
| collection | DOAJ |
| description | Aim. To evaluate 24-month outcomes after hospital treatment of patients with coronavirus disease 2019 (COVID-19) in a prospective registry.Material and methods. Two-year outcomes (2,2±0,5) after hospital treatment for COVID-19 were analyzed in 802 patients (mean age, 59,8±14,5 years, men, 51,0%). We assessed cases of death, non-fatal myocardial infarction (MI) and stroke, revascularization operations, hospitalizations, recurrent COVID-19, vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Results. During the follow-up period, 49 (5,9%) patients died, while 7 (0,8%) patients had MI, 7 (0,8%) — stroke. In addition, 222 (26,7%) patients were hospitalized, of which 26 (3,1%) for COVID-19. Recurrent COVID-19 were revealed in 146 (17,6%) patients, while 414 (49,6%) patients were vaccinated for SARS-CoV-2. The factors of age and stay in the intensive care unit were significantly associated (p<0,001) with the risk of all-cause death (hazard ratio (HR)=1,083 per 1 year of life and HR=6,28, respectively) and composite endpoint (death, non-fatal myocardial infarction, stroke, revascularization surgery): HR=1,057 and HR=3,28, respectively. Male sex was associated with the death risk (HR=2,50, p=0,003). Of the 49 deaths, 19 (38,8%) occurred in the first 3 months, and 35 (71,4%) in the first year of follow-up. A lower (1,8 times) incidence of new cases of cardiovascular (CVD) diseases and non- CVDs were associated with initial cardiovascular pathology. Hospitalization was associated with age (odds ratio (OR)=1,027; p<0,001) and CVDs (OR=1,66; p=0,01). The risk of recurrent COVID-19 was higher with CVDs (OR=1,55; p=0,03), lower — among those vaccinated for SARS-CoV-2 (OR=0,49; p<0,001).Conclusion. Over two-year follow-up of patients after hospital treatment for COVID-19, the proportion of deaths was 5,9%: >1/3 of deaths recorded in the first 3 months and >2/3 during the first year. Factors associated with death were age, male sex, and intensive care unit treatment during the hospitalization. The readmission rate was associated with older age and CVDs. The risk of repeated cases of COVID-19 was one and a half times higher in the presence of CVDs, but 2 times lower in those vaccinated for SARS-CoV-2 in the post- COVID-19 period. |
| format | Article |
| id | doaj-art-4337640b31024ccd9f685b0318cb1fb1 |
| institution | Kabale University |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2023-11-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-4337640b31024ccd9f685b0318cb1fb12025-08-20T03:35:51Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252023-11-01221010.15829/1728-8800-2023-37572808Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registryM. M. Lukyanov0E. Yu. Andreenko1S. Yu. Martsevich2N. P. Kutishenko3V. P. Voronina4V. A. Dindikova5N. A. Dmitrieva6M. M. Kudryavtseva7O. V. Lerman8A. N. Makoveeva9E. Yu. Okshina10A. A. Pulin11А. А. Smirnov12V. G. Klyashtorny13O. E. Karpov14O. M. Drapkina15National Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicinePirogov National Medical and Surgical CenterNational Medical Research Center for Therapy and Preventive MedicineNational Medical Research Center for Therapy and Preventive MedicinePirogov National Medical and Surgical CenterNational Medical Research Center for Therapy and Preventive MedicineAim. To evaluate 24-month outcomes after hospital treatment of patients with coronavirus disease 2019 (COVID-19) in a prospective registry.Material and methods. Two-year outcomes (2,2±0,5) after hospital treatment for COVID-19 were analyzed in 802 patients (mean age, 59,8±14,5 years, men, 51,0%). We assessed cases of death, non-fatal myocardial infarction (MI) and stroke, revascularization operations, hospitalizations, recurrent COVID-19, vaccination for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Results. During the follow-up period, 49 (5,9%) patients died, while 7 (0,8%) patients had MI, 7 (0,8%) — stroke. In addition, 222 (26,7%) patients were hospitalized, of which 26 (3,1%) for COVID-19. Recurrent COVID-19 were revealed in 146 (17,6%) patients, while 414 (49,6%) patients were vaccinated for SARS-CoV-2. The factors of age and stay in the intensive care unit were significantly associated (p<0,001) with the risk of all-cause death (hazard ratio (HR)=1,083 per 1 year of life and HR=6,28, respectively) and composite endpoint (death, non-fatal myocardial infarction, stroke, revascularization surgery): HR=1,057 and HR=3,28, respectively. Male sex was associated with the death risk (HR=2,50, p=0,003). Of the 49 deaths, 19 (38,8%) occurred in the first 3 months, and 35 (71,4%) in the first year of follow-up. A lower (1,8 times) incidence of new cases of cardiovascular (CVD) diseases and non- CVDs were associated with initial cardiovascular pathology. Hospitalization was associated with age (odds ratio (OR)=1,027; p<0,001) and CVDs (OR=1,66; p=0,01). The risk of recurrent COVID-19 was higher with CVDs (OR=1,55; p=0,03), lower — among those vaccinated for SARS-CoV-2 (OR=0,49; p<0,001).Conclusion. Over two-year follow-up of patients after hospital treatment for COVID-19, the proportion of deaths was 5,9%: >1/3 of deaths recorded in the first 3 months and >2/3 during the first year. Factors associated with death were age, male sex, and intensive care unit treatment during the hospitalization. The readmission rate was associated with older age and CVDs. The risk of repeated cases of COVID-19 was one and a half times higher in the presence of CVDs, but 2 times lower in those vaccinated for SARS-CoV-2 in the post- COVID-19 period.https://cardiovascular.elpub.ru/jour/article/view/3757coronavirus disease 2019covid-19registryprospective follow-uplong-term outcomesvaccinationcardiovascular diseaseschronic non-cardiovascular diseasescomorbidity |
| spellingShingle | M. M. Lukyanov E. Yu. Andreenko S. Yu. Martsevich N. P. Kutishenko V. P. Voronina V. A. Dindikova N. A. Dmitrieva M. M. Kudryavtseva O. V. Lerman A. N. Makoveeva E. Yu. Okshina A. A. Pulin А. А. Smirnov V. G. Klyashtorny O. E. Karpov O. M. Drapkina Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registry Кардиоваскулярная терапия и профилактика coronavirus disease 2019 covid-19 registry prospective follow-up long-term outcomes vaccination cardiovascular diseases chronic non-cardiovascular diseases comorbidity |
| title | Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registry |
| title_full | Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registry |
| title_fullStr | Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registry |
| title_full_unstemmed | Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registry |
| title_short | Two-year outcomes in patients after hospitalization for COVID-19: data from the TARGET-VIP registry |
| title_sort | two year outcomes in patients after hospitalization for covid 19 data from the target vip registry |
| topic | coronavirus disease 2019 covid-19 registry prospective follow-up long-term outcomes vaccination cardiovascular diseases chronic non-cardiovascular diseases comorbidity |
| url | https://cardiovascular.elpub.ru/jour/article/view/3757 |
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