Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors

Open-source electrophilic fragment screening platform to identify chemical starting points for UCHL1 covalent inhibitors

Target-based screening of covalent fragment libraries with mass spectrometry has emerged as a powerful strategy to identify chemical starting points for small molecule inhibitors or find new binding pockets on proteins of interest. These libraries span diverse chemical space with a modest number of...

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Bibliographic Details
Main Authors: Scott B. Ficarro, Zachary H. Marto, Nicholas M. Girardi, Dingyu Deng, Isabella Jaen Maisonet, Guillaume Adelmant, Laura E. Fleming, Mona Sharafi, Isidoro Tavares, Andrew Zhao, HyoJeon Kim, Hyuk-Soo Seo, Sirano Dhe-Paganon, Sara J. Buhrlage, Jarrod A. Marto
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:SLAS Discovery
Subjects:
Deubiquitinating enzymes
UCHL1
Open-source hardware and software
Covalent fragment screening
Electrophilic fragments
Intact protein LC–MS screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555224000601
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