Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism
Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD development and severity, recent studies have focused on elucidating th...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2447822 |
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| author | Naika Prince Lucia N. Peralta Marzal Léa Roussin Magali Monnoye Catherine Philippe Elise Maximin Sabbir Ahmed Karoliina Salenius Jake Lin Reija Autio Youri Adolfs R. Jeroen Pasterkamp Johan Garssen Laurent Naudon Sylvie Rabot Aletta D. Kraneveld Paula Perez-Pardo |
| author_facet | Naika Prince Lucia N. Peralta Marzal Léa Roussin Magali Monnoye Catherine Philippe Elise Maximin Sabbir Ahmed Karoliina Salenius Jake Lin Reija Autio Youri Adolfs R. Jeroen Pasterkamp Johan Garssen Laurent Naudon Sylvie Rabot Aletta D. Kraneveld Paula Perez-Pardo |
| author_sort | Naika Prince |
| collection | DOAJ |
| description | Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD development and severity, recent studies have focused on elucidating the microbiota-gut-brain axis’ involvement. This study aims to explore mechanisms through which gut microbiota might influence ASD. Briefly, we depleted the microbiota of conventional male BALB/cAnNCrl (Balb/c) and C57BL/6J (BL/6) mice prior to human fecal microbiota transplantation (hFMT) with samples from children with ASD or their neurotypical siblings. We found mouse strain-specific responses to ASD hFMT. Notably, Balb/c mice exhibit decreased exploratory and social behavior, and show evidence of intestinal, systemic, and central inflammation accompanied with metabolic shifts. BL/6 mice show less changes after hFMT. Our results reveal that gut microbiota alone induce changes in ASD-like behavior, and highlight the importance of mouse strain selection when investigating multifactorial conditions like ASD. |
| format | Article |
| id | doaj-art-432f69193dec4a2ab43dc6f3f965a053 |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-432f69193dec4a2ab43dc6f3f965a0532025-01-12T11:49:38ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2024.2447822Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autismNaika Prince0Lucia N. Peralta Marzal1Léa Roussin2Magali Monnoye3Catherine Philippe4Elise Maximin5Sabbir Ahmed6Karoliina Salenius7Jake Lin8Reija Autio9Youri Adolfs10R. Jeroen Pasterkamp11Johan Garssen12Laurent Naudon13Sylvie Rabot14Aletta D. Kraneveld15Paula Perez-Pardo16Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsDivision of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, FranceUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, FranceUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, FranceUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, FranceDivision of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsFaculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere, FinlandHealth Sciences, Faculty of Social Sciences, Tampere University, Tampere, FinlandHealth Sciences, Faculty of Social Sciences, Tampere University, Tampere, FinlandDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDepartment of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, NetherlandsDivision of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsUniversité Paris-Saclay, INRAE, AgroParisTech, CNRS, Micalis Institute, Jouy-en-Josas, FranceUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, FranceDivision of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsDivision of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsSeveral factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD development and severity, recent studies have focused on elucidating the microbiota-gut-brain axis’ involvement. This study aims to explore mechanisms through which gut microbiota might influence ASD. Briefly, we depleted the microbiota of conventional male BALB/cAnNCrl (Balb/c) and C57BL/6J (BL/6) mice prior to human fecal microbiota transplantation (hFMT) with samples from children with ASD or their neurotypical siblings. We found mouse strain-specific responses to ASD hFMT. Notably, Balb/c mice exhibit decreased exploratory and social behavior, and show evidence of intestinal, systemic, and central inflammation accompanied with metabolic shifts. BL/6 mice show less changes after hFMT. Our results reveal that gut microbiota alone induce changes in ASD-like behavior, and highlight the importance of mouse strain selection when investigating multifactorial conditions like ASD.https://www.tandfonline.com/doi/10.1080/19490976.2024.2447822Fecal microbiota transplantationhumanized mouse modelgut-brain axisautism spectrum disorders |
| spellingShingle | Naika Prince Lucia N. Peralta Marzal Léa Roussin Magali Monnoye Catherine Philippe Elise Maximin Sabbir Ahmed Karoliina Salenius Jake Lin Reija Autio Youri Adolfs R. Jeroen Pasterkamp Johan Garssen Laurent Naudon Sylvie Rabot Aletta D. Kraneveld Paula Perez-Pardo Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism Gut Microbes Fecal microbiota transplantation humanized mouse model gut-brain axis autism spectrum disorders |
| title | Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism |
| title_full | Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism |
| title_fullStr | Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism |
| title_full_unstemmed | Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism |
| title_short | Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism |
| title_sort | mouse strain specific responses along the gut brain axis upon fecal microbiota transplantation from children with autism |
| topic | Fecal microbiota transplantation humanized mouse model gut-brain axis autism spectrum disorders |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2447822 |
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