Spectrum of renal diseases in the pediatric population of Nepal
Background: The spectrum of renal diseases varies with different ethnic populations, geographical locations and environmental factors. In children, many signs of kidney disease are either hidden or mimic other systemic diseases. There is a need of identifying renal disorders at an early stage to ret...
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Association of Clinical Pathologists of Nepal
2024-10-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/65917 |
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| author | Nirajan Mainali Barsha acharya Ganesh Phulara |
| author_facet | Nirajan Mainali Barsha acharya Ganesh Phulara |
| author_sort | Nirajan Mainali |
| collection | DOAJ |
| description | Background: The spectrum of renal diseases varies with different ethnic populations, geographical locations and environmental factors. In children, many signs of kidney disease are either hidden or mimic other systemic diseases. There is a need of identifying renal disorders at an early stage to retard the rapid progression. This study aims to identify the different histopathological spectrum of glomerular diseases in pediatric renal biopsies.
Materials and Methods: This was a cross-sectional prospective study undertaken at the Pathology Department at Pratham Pathology Laboratory, Lazimpat for 17 months duration (May 1ST - December 31ST 2023). The final diagnosis was made by a pathologist after correlating the histopathological findings with immunofluorescence and other clinical and laboratory findings.
Results: A total of 97 pediatric patients’ renal biopsy specimens were evaluated. Patients’ age ranged from 0-16 years. The majority of patients were in the age group of 11-16 years (62.8%). The study showed slight female predominance with male to female ratio of 0.8:1. The most common glomerular disease was Lupus Nephritis with a frequency of 19 (19.6%). The most common cause for Rapid progressive Glomerulonephritis in the pediatric population was Post Infectious Glomerulonephritis with a frequency of 5 (50%).
Conclusions: The most commonly diagnosed glomerular disease in pediatric renal biopsies was Lupus Nephritis. The leading cause of Rapid Progressive Glomerulonephritis was Post Infectious Glomerulonephritis and Lupus was one of the leading causes of chronic kidney disease. |
| format | Article |
| id | doaj-art-432ea26e53b640fd89ffbbb8a834d15f |
| institution | Kabale University |
| issn | 2091-0797 2091-0908 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj-art-432ea26e53b640fd89ffbbb8a834d15f2025-08-21T06:55:17ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082024-10-011412150215510.3126/jpn.v14i1.6591793047Spectrum of renal diseases in the pediatric population of NepalNirajan Mainali0https://orcid.org/0000-0002-6648-1914Barsha acharya1Ganesh Phulara2Kathmandu Medical College Teaching Hospital, Kathmandu, Nepal.Department of Pathology, Pratham Pathology Laboratory, Lazimpat, Kathmandu, NepalDepartment of Pathology, Pratham Pathology Laboratory, Lazimpat, Kathmandu, NepalBackground: The spectrum of renal diseases varies with different ethnic populations, geographical locations and environmental factors. In children, many signs of kidney disease are either hidden or mimic other systemic diseases. There is a need of identifying renal disorders at an early stage to retard the rapid progression. This study aims to identify the different histopathological spectrum of glomerular diseases in pediatric renal biopsies. Materials and Methods: This was a cross-sectional prospective study undertaken at the Pathology Department at Pratham Pathology Laboratory, Lazimpat for 17 months duration (May 1ST - December 31ST 2023). The final diagnosis was made by a pathologist after correlating the histopathological findings with immunofluorescence and other clinical and laboratory findings. Results: A total of 97 pediatric patients’ renal biopsy specimens were evaluated. Patients’ age ranged from 0-16 years. The majority of patients were in the age group of 11-16 years (62.8%). The study showed slight female predominance with male to female ratio of 0.8:1. The most common glomerular disease was Lupus Nephritis with a frequency of 19 (19.6%). The most common cause for Rapid progressive Glomerulonephritis in the pediatric population was Post Infectious Glomerulonephritis with a frequency of 5 (50%). Conclusions: The most commonly diagnosed glomerular disease in pediatric renal biopsies was Lupus Nephritis. The leading cause of Rapid Progressive Glomerulonephritis was Post Infectious Glomerulonephritis and Lupus was one of the leading causes of chronic kidney disease.https://www.nepjol.info/index.php/JPN/article/view/65917chronic kidney diseaseglomerular diseasesimmunofluorescencelight microscopypediatric renal diseasepost-infectious glomerulonephritisrapidly progressive glomerulonephritis |
| spellingShingle | Nirajan Mainali Barsha acharya Ganesh Phulara Spectrum of renal diseases in the pediatric population of Nepal Journal of Pathology of Nepal chronic kidney disease glomerular diseases immunofluorescence light microscopy pediatric renal disease post-infectious glomerulonephritis rapidly progressive glomerulonephritis |
| title | Spectrum of renal diseases in the pediatric population of Nepal |
| title_full | Spectrum of renal diseases in the pediatric population of Nepal |
| title_fullStr | Spectrum of renal diseases in the pediatric population of Nepal |
| title_full_unstemmed | Spectrum of renal diseases in the pediatric population of Nepal |
| title_short | Spectrum of renal diseases in the pediatric population of Nepal |
| title_sort | spectrum of renal diseases in the pediatric population of nepal |
| topic | chronic kidney disease glomerular diseases immunofluorescence light microscopy pediatric renal disease post-infectious glomerulonephritis rapidly progressive glomerulonephritis |
| url | https://www.nepjol.info/index.php/JPN/article/view/65917 |
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