Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma
Steroid-insensitive asthma is an infrequent but problematic airway disease that presents with persistent symptoms, airflow limitation, or recurrent exacerbations even when treated with steroid-based therapies. Because of unsatisfactory results obtained from currently available therapies for steroid-...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/609395 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850109915061813248 |
|---|---|
| author | Yuko Morishima Satoshi Ano Yukio Ishii Shigeo Ohtsuka Masashi Matsuyama Mio Kawaguchi Nobuyuki Hizawa |
| author_facet | Yuko Morishima Satoshi Ano Yukio Ishii Shigeo Ohtsuka Masashi Matsuyama Mio Kawaguchi Nobuyuki Hizawa |
| author_sort | Yuko Morishima |
| collection | DOAJ |
| description | Steroid-insensitive asthma is an infrequent but problematic airway disease that presents with persistent symptoms, airflow limitation, or recurrent exacerbations even when treated with steroid-based therapies. Because of unsatisfactory results obtained from currently available therapies for steroid-insensitive asthma, a better understanding of its pathogenesis and the development of new targeted molecular therapies are warranted. Recent studies indicated that levels of interleukin (IL)-17 are increased and both eosinophils and neutrophils infiltrate the airways of severe asthmatics. IL-17 is a proinflammatory cytokine mainly secreted from helper T (Th) 17 cells and is important for the induction of neutrophil recruitment and migration at sites of inflammation. This review focuses on the pathogenetic role of Th17 cells and their associated cytokines in steroid-insensitive asthma and discusses the prospects of novel therapeutic options targeting the Th17 signaling pathway. |
| format | Article |
| id | doaj-art-4329eb2aa32a40db877d354ba32d478f |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-4329eb2aa32a40db877d354ba32d478f2025-08-20T02:37:57ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/609395609395Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive AsthmaYuko Morishima0Satoshi Ano1Yukio Ishii2Shigeo Ohtsuka3Masashi Matsuyama4Mio Kawaguchi5Nobuyuki Hizawa6Division of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, JapanDivision of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, JapanDivision of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, JapanDivision of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, JapanDivision of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, JapanDivision of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, JapanDivision of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, JapanSteroid-insensitive asthma is an infrequent but problematic airway disease that presents with persistent symptoms, airflow limitation, or recurrent exacerbations even when treated with steroid-based therapies. Because of unsatisfactory results obtained from currently available therapies for steroid-insensitive asthma, a better understanding of its pathogenesis and the development of new targeted molecular therapies are warranted. Recent studies indicated that levels of interleukin (IL)-17 are increased and both eosinophils and neutrophils infiltrate the airways of severe asthmatics. IL-17 is a proinflammatory cytokine mainly secreted from helper T (Th) 17 cells and is important for the induction of neutrophil recruitment and migration at sites of inflammation. This review focuses on the pathogenetic role of Th17 cells and their associated cytokines in steroid-insensitive asthma and discusses the prospects of novel therapeutic options targeting the Th17 signaling pathway.http://dx.doi.org/10.1155/2013/609395 |
| spellingShingle | Yuko Morishima Satoshi Ano Yukio Ishii Shigeo Ohtsuka Masashi Matsuyama Mio Kawaguchi Nobuyuki Hizawa Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma Clinical and Developmental Immunology |
| title | Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma |
| title_full | Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma |
| title_fullStr | Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma |
| title_full_unstemmed | Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma |
| title_short | Th17-Associated Cytokines as a Therapeutic Target for Steroid-Insensitive Asthma |
| title_sort | th17 associated cytokines as a therapeutic target for steroid insensitive asthma |
| url | http://dx.doi.org/10.1155/2013/609395 |
| work_keys_str_mv | AT yukomorishima th17associatedcytokinesasatherapeutictargetforsteroidinsensitiveasthma AT satoshiano th17associatedcytokinesasatherapeutictargetforsteroidinsensitiveasthma AT yukioishii th17associatedcytokinesasatherapeutictargetforsteroidinsensitiveasthma AT shigeoohtsuka th17associatedcytokinesasatherapeutictargetforsteroidinsensitiveasthma AT masashimatsuyama th17associatedcytokinesasatherapeutictargetforsteroidinsensitiveasthma AT miokawaguchi th17associatedcytokinesasatherapeutictargetforsteroidinsensitiveasthma AT nobuyukihizawa th17associatedcytokinesasatherapeutictargetforsteroidinsensitiveasthma |