Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R

Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R

Abstract G protein-coupled receptors (GPCRs) are important therapeutic drug targets for a wide range of diseases. Upon activation, GPCRs can initiate several signaling pathways, each with unique therapeutic implications. Therefore, understanding how drugs selectively engage specific signaling pathwa...

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Main Authors: Adrian Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza, Tomasz Maciej Stępniewski, Vicente Ledesma-Martin, Franziska M. Heydenreich, Tilman Flock, Bianca Plouffe, Christian Le Gouill, Jean Duchaine, David A. Sykes, Colin Nicholson, Eline J. Koers, Wolfgang Guba, Arne C. Rufer, Uwe Grether, Michel Bouvier, Dmitry B. Veprintsev, Jana Selent
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60003-0
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