High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine care
Abstract Background People with HIV (PWH) are at risk of co-infections, such as latent tuberculosis (LTBI), hepatitis B (HBV), hepatitis C (HCV), and syphilis; hence, routine screening is critical. However, evaluation of routine screening is not being fully implemented in Ghana. This study assessed...
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BMC
2025-06-01
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| Series: | AIDS Research and Therapy |
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| Online Access: | https://doi.org/10.1186/s12981-025-00756-2 |
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| author | Helena Lamptey James Odame Aboagye Christopher Zaab-Yen Abana Anthony Twumasi Boateng Ephraim Mawufemor Kofi Kanda Dzidzor Aku Attoh Araba Abaidoo-Myles Charlotte Borteley Bortey Jonathan Klutse Peter Puplampu Gloria Ansa Vincent Jessey Ganu Joseph Oliver-Commey Evelyn Yayra Bonney George Boateng Kyei |
| author_facet | Helena Lamptey James Odame Aboagye Christopher Zaab-Yen Abana Anthony Twumasi Boateng Ephraim Mawufemor Kofi Kanda Dzidzor Aku Attoh Araba Abaidoo-Myles Charlotte Borteley Bortey Jonathan Klutse Peter Puplampu Gloria Ansa Vincent Jessey Ganu Joseph Oliver-Commey Evelyn Yayra Bonney George Boateng Kyei |
| author_sort | Helena Lamptey |
| collection | DOAJ |
| description | Abstract Background People with HIV (PWH) are at risk of co-infections, such as latent tuberculosis (LTBI), hepatitis B (HBV), hepatitis C (HCV), and syphilis; hence, routine screening is critical. However, evaluation of routine screening is not being fully implemented in Ghana. This study assessed the prevalence of these co-infections among PWH in Accra, Ghana. Methods The HIV Cure Research Infrastructure Study (H-CRIS) followed 390 PWH from three HIV treatment centres in Accra. A cross-sectional study was conducted within this cohort, and participants were screened for LTBI, hepatitis B, hepatitis C, and syphilis using standardized assays. LTBI was detected using the QuantiFERON-TB Gold Plus assay. Syphilis testing included treponemal and non-treponemal assays. HBV and HCV were tested using rapid test kits. Data was collected on demographics, viral load, CD4 count, ART regimen, and therapy duration. Descriptive statistics used frequency and proportion, while inferential analysis employed chi-square tests, t-tests, and odds ratios (OR) to assess associations. Results Among 390 participants, median age: 45 years (IQR: 39–52 years), 69% (269/390) were virologically suppressed, and 80% (312/390) had CD4 counts above 350 cells/µL. The prevalence of co-infections was 12% (48/390) for HBV, 10.8% (42/390) for LTBI, 12.5% (40/320) for syphilis, and 1% (4/390) for HCV, with 2% (8/390) having more than two co-infections. LTBI was associated with age (> 60 years; OR = 3.5) and years of HIV diagnosis (> 10 years; OR = 2.2). Conclusion The significant burden of co-infections among PWH in Ghana highlights the urgent need to integrate routine screening into HIV care. |
| format | Article |
| id | doaj-art-431f33f73407489884c7dff708afbbb8 |
| institution | Kabale University |
| issn | 1742-6405 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
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| series | AIDS Research and Therapy |
| spelling | doaj-art-431f33f73407489884c7dff708afbbb82025-08-20T03:45:32ZengBMCAIDS Research and Therapy1742-64052025-06-012211910.1186/s12981-025-00756-2High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine careHelena Lamptey0James Odame Aboagye1Christopher Zaab-Yen Abana2Anthony Twumasi Boateng3Ephraim Mawufemor Kofi Kanda4Dzidzor Aku Attoh5Araba Abaidoo-Myles6Charlotte Borteley Bortey7Jonathan Klutse8Peter Puplampu9Gloria Ansa10Vincent Jessey Ganu11Joseph Oliver-Commey12Evelyn Yayra Bonney13George Boateng Kyei14Departments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartment of Medicine and Therapeutics,University of Ghana Medical School, College of Health Sciences, University of GhanaDepartment of Public Health, University of Ghana HospitalDepartment of Medicine and Therapeutics,University of Ghana Medical School, College of Health Sciences, University of GhanaLEKMA HospitalDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaDepartments of Immunology and Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of GhanaAbstract Background People with HIV (PWH) are at risk of co-infections, such as latent tuberculosis (LTBI), hepatitis B (HBV), hepatitis C (HCV), and syphilis; hence, routine screening is critical. However, evaluation of routine screening is not being fully implemented in Ghana. This study assessed the prevalence of these co-infections among PWH in Accra, Ghana. Methods The HIV Cure Research Infrastructure Study (H-CRIS) followed 390 PWH from three HIV treatment centres in Accra. A cross-sectional study was conducted within this cohort, and participants were screened for LTBI, hepatitis B, hepatitis C, and syphilis using standardized assays. LTBI was detected using the QuantiFERON-TB Gold Plus assay. Syphilis testing included treponemal and non-treponemal assays. HBV and HCV were tested using rapid test kits. Data was collected on demographics, viral load, CD4 count, ART regimen, and therapy duration. Descriptive statistics used frequency and proportion, while inferential analysis employed chi-square tests, t-tests, and odds ratios (OR) to assess associations. Results Among 390 participants, median age: 45 years (IQR: 39–52 years), 69% (269/390) were virologically suppressed, and 80% (312/390) had CD4 counts above 350 cells/µL. The prevalence of co-infections was 12% (48/390) for HBV, 10.8% (42/390) for LTBI, 12.5% (40/320) for syphilis, and 1% (4/390) for HCV, with 2% (8/390) having more than two co-infections. LTBI was associated with age (> 60 years; OR = 3.5) and years of HIV diagnosis (> 10 years; OR = 2.2). Conclusion The significant burden of co-infections among PWH in Ghana highlights the urgent need to integrate routine screening into HIV care.https://doi.org/10.1186/s12981-025-00756-2HIV-1Latent TB infectionHBVSyphilisGhanaCo-infections |
| spellingShingle | Helena Lamptey James Odame Aboagye Christopher Zaab-Yen Abana Anthony Twumasi Boateng Ephraim Mawufemor Kofi Kanda Dzidzor Aku Attoh Araba Abaidoo-Myles Charlotte Borteley Bortey Jonathan Klutse Peter Puplampu Gloria Ansa Vincent Jessey Ganu Joseph Oliver-Commey Evelyn Yayra Bonney George Boateng Kyei High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine care AIDS Research and Therapy HIV-1 Latent TB infection HBV Syphilis Ghana Co-infections |
| title | High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine care |
| title_full | High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine care |
| title_fullStr | High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine care |
| title_full_unstemmed | High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine care |
| title_short | High prevalence of co-infections with latent tuberculosis, syphilis and hepatitis B and C among people with HIV in Ghana: a call for integrating screening into routine care |
| title_sort | high prevalence of co infections with latent tuberculosis syphilis and hepatitis b and c among people with hiv in ghana a call for integrating screening into routine care |
| topic | HIV-1 Latent TB infection HBV Syphilis Ghana Co-infections |
| url | https://doi.org/10.1186/s12981-025-00756-2 |
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