Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases
Due to exposure factors such as industrial exhaust, sewage discharge, pesticide runoff, automobile exhaust, and fuel combustion, environmental toxicants are widely present in daily life. Organisms are exposed to these environmental toxicants through contaminated air, food, and drinking water, and th...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325006050 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850268454587727872 |
|---|---|
| author | Hong Chen Bingchun Liu Peixin Xu Huizeng Wang Xin Guo Gang Liu Jianlong Yuan |
| author_facet | Hong Chen Bingchun Liu Peixin Xu Huizeng Wang Xin Guo Gang Liu Jianlong Yuan |
| author_sort | Hong Chen |
| collection | DOAJ |
| description | Due to exposure factors such as industrial exhaust, sewage discharge, pesticide runoff, automobile exhaust, and fuel combustion, environmental toxicants are widely present in daily life. Organisms are exposed to these environmental toxicants through contaminated air, food, and drinking water, and these environmental toxicants enter the human body and cause cytotoxicity and diseases through various pathways. As a new cell death mode that is different from cell necrosis, apoptosis, and autophagy, ferroptosis are mainly dysregulation of intracellular iron metabolism, lipid metabolism disorders, and the dysregulation of the antioxidant defense system, leading to lipid peroxidation and ultimately to the rupture of the cell membrane, damage, and cell death. Studies have shown that environmental toxicants induce a series of diseases, such as digestive diseases, urinary diseases, respiratory diseases, neurological disorders, and reproductive diseases, through the above mechanisms. We elaborate the mechanism of common environmental toxicants in inducing ferroptosis and the related systemic diseases mediated through the ferroptosis to provide the theoretical basis for preventing and treating environmental toxicant-related diseases. Nonetheless, our understanding of ferroptosis remains incomplete. For example, mechanisms and methods for the selective control of ferroptosis remain elusive, elucidating these mechanisms and strategies may be critical for leveraging knowledge of ferroptosis to treat related diseases. |
| format | Article |
| id | doaj-art-431c087b3b9d46fbb2bb441614bab2c4 |
| institution | OA Journals |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-431c087b3b9d46fbb2bb441614bab2c42025-08-20T01:53:27ZengElsevierEcotoxicology and Environmental Safety0147-65132025-06-0129811826910.1016/j.ecoenv.2025.118269Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseasesHong Chen0Bingchun Liu1Peixin Xu2Huizeng Wang3Xin Guo4Gang Liu5Jianlong Yuan6Department of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia 010050, ChinaStem Cell Laboratory; Central Laboratory of Organ Transplantation;Inner Mongolia Autonomous Region Engineering Laboratory for Genetic Test and Research of Tumor Cells, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia 010050, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia 010050, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia 010050, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia 010050, ChinaClinical Medicine Research Center, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia 010050, ChinaDepartment of Clinical Laboratory, Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Hohhot, Inner Mongolia 010050, China; Corresponding author.Due to exposure factors such as industrial exhaust, sewage discharge, pesticide runoff, automobile exhaust, and fuel combustion, environmental toxicants are widely present in daily life. Organisms are exposed to these environmental toxicants through contaminated air, food, and drinking water, and these environmental toxicants enter the human body and cause cytotoxicity and diseases through various pathways. As a new cell death mode that is different from cell necrosis, apoptosis, and autophagy, ferroptosis are mainly dysregulation of intracellular iron metabolism, lipid metabolism disorders, and the dysregulation of the antioxidant defense system, leading to lipid peroxidation and ultimately to the rupture of the cell membrane, damage, and cell death. Studies have shown that environmental toxicants induce a series of diseases, such as digestive diseases, urinary diseases, respiratory diseases, neurological disorders, and reproductive diseases, through the above mechanisms. We elaborate the mechanism of common environmental toxicants in inducing ferroptosis and the related systemic diseases mediated through the ferroptosis to provide the theoretical basis for preventing and treating environmental toxicant-related diseases. Nonetheless, our understanding of ferroptosis remains incomplete. For example, mechanisms and methods for the selective control of ferroptosis remain elusive, elucidating these mechanisms and strategies may be critical for leveraging knowledge of ferroptosis to treat related diseases.http://www.sciencedirect.com/science/article/pii/S0147651325006050Environmental toxicantsOrganic poisonHeavy metalFerroptosisDisease |
| spellingShingle | Hong Chen Bingchun Liu Peixin Xu Huizeng Wang Xin Guo Gang Liu Jianlong Yuan Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases Ecotoxicology and Environmental Safety Environmental toxicants Organic poison Heavy metal Ferroptosis Disease |
| title | Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases |
| title_full | Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases |
| title_fullStr | Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases |
| title_full_unstemmed | Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases |
| title_short | Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases |
| title_sort | mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases |
| topic | Environmental toxicants Organic poison Heavy metal Ferroptosis Disease |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325006050 |
| work_keys_str_mv | AT hongchen mechanisticroleofenvironmentaltoxicantsininducingcellularferroptosisanditsassociateddiseases AT bingchunliu mechanisticroleofenvironmentaltoxicantsininducingcellularferroptosisanditsassociateddiseases AT peixinxu mechanisticroleofenvironmentaltoxicantsininducingcellularferroptosisanditsassociateddiseases AT huizengwang mechanisticroleofenvironmentaltoxicantsininducingcellularferroptosisanditsassociateddiseases AT xinguo mechanisticroleofenvironmentaltoxicantsininducingcellularferroptosisanditsassociateddiseases AT gangliu mechanisticroleofenvironmentaltoxicantsininducingcellularferroptosisanditsassociateddiseases AT jianlongyuan mechanisticroleofenvironmentaltoxicantsininducingcellularferroptosisanditsassociateddiseases |