Glucocorticoids induce femoral head necrosis in rats through the HIF-1α/VEGF signaling pathway

Glucocorticoids induce femoral head necrosis in rats through the HIF-1α/VEGF signaling pathway

Abstract Glucocorticoid-induced osteoblast dysfunction is the primary cause of steroid-induced osteonecrosis of the femoral head (SONFH). However, the specific underlying biological mechanisms of glucocorticoids’ effect on osteoblasts remain undetermined. Recently, the role of hypoxia-inducible fact...

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Bibliographic Details
Main Authors: HaoXu Tang, Lingli Yuan, ZhiYuan Xu, GuiFen Jiang, YingJie Liang, Ce Li, PengLin Ding, MinLong Qian
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Steroid-induced osteonecrosis of the femoral head
HIF-1α
VEGF
Osteoblasts
Osteogenic differentiation
Online Access:https://doi.org/10.1038/s41598-025-15018-4
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