Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CT
<b>Objectives:</b> Our study aims to investigate the correlation between epicardial adipose tissue (EAT) volume assessed with non-contrast cardiac CT (NCCCT) and sex, age, coronary artery disease reporting and data system (CAD-RADS 2.0) categories, and coronary artery calcification (CAC)...
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MDPI AG
2025-03-01
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| author | Federica Dell’Aversana Renato Tuccillo Alessandro Monfregola Leda De Angelis Giovanni Ferrandino Carlo Tedeschi Fulvio Cacciapuoti Fabio Tamburro Carlo Liguori |
| author_facet | Federica Dell’Aversana Renato Tuccillo Alessandro Monfregola Leda De Angelis Giovanni Ferrandino Carlo Tedeschi Fulvio Cacciapuoti Fabio Tamburro Carlo Liguori |
| author_sort | Federica Dell’Aversana |
| collection | DOAJ |
| description | <b>Objectives:</b> Our study aims to investigate the correlation between epicardial adipose tissue (EAT) volume assessed with non-contrast cardiac CT (NCCCT) and sex, age, coronary artery disease reporting and data system (CAD-RADS 2.0) categories, and coronary artery calcification (CAC) extent. The secondary aim is to establish the average values of EAT in a population considered healthy for coronary artery disease (CAD). <b>Materials and Methods:</b> We retrospectively analyzed patients who underwent coronary computed tomography angiography (CCTA) at our institution from January 2023 to August 2024. The CAD-RADS 2.0 scoring system was applied to assess the extent of CAD; CAC extent was quantified according to the Agatston score. EAT was segmented semi-automatically in NCCCT images, and its volume was subsequently measured. Correlation analyses between EAT volume, sex, patient age, CAC, and CAD-RADS categories were conducted. <b>Results:</b> A total of 489 consecutive patients met the inclusion criteria (63.96 ± 12.18 years; 214 females). The mean EAT volume ± SD in those categorized as CAD-RADS 0 (57.25 ± 15.45 years, 120 patients) was 117.43 ± 50.30 cm<sup>3</sup>: values were higher in men (121.07 ± 53.31 cm<sup>3</sup>) than in women (114.54 ± 47.98 cm<sup>3</sup>). EAT volumes positively correlated with age, male sex, CAD severity, and CAC scores. <b>Conclusions:</b> According to our results, males in all CAD-RADS categories have a greater amount of EAT than females. A positive correlation between the volume of EAT and factors such as age (<i>p</i> = 0.003), CAD-RADS categories (<i>p</i>: 0.004), and coronary calcium score (<i>p</i> = 0.0001) with a strong influence exerted by sex was demonstrated. Our results reinforce the observation that higher EAT volumes are associated with a more severe coronary artery disease. |
| format | Article |
| id | doaj-art-431af62791be4b2c86fb6c033fd21479 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-03-01 |
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| spelling | doaj-art-431af62791be4b2c86fb6c033fd214792025-08-20T02:11:18ZengMDPI AGDiagnostics2075-44182025-03-0115668110.3390/diagnostics15060681Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CTFederica Dell’Aversana0Renato Tuccillo1Alessandro Monfregola2Leda De Angelis3Giovanni Ferrandino4Carlo Tedeschi5Fulvio Cacciapuoti6Fabio Tamburro7Carlo Liguori8Department of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDepartment of Precision Medicine, University of Campania “L. Vanvitelli”, 80138 Naples, ItalyDivision of Radiology, University of Napoli “Federico II”, 80131 Naples, ItalyDivision of Radiology, University of Napoli “Federico II”, 80131 Naples, ItalyDepartment of Radiology, Ospedale del Mare-ASL Napoli 1, 80147 Naples, ItalyOperational Unit of Cardiology, Presidio Sanitario Intermedio Napoli Est, ASL-Napoli 1 Centro, 80144 Naples, ItalyDepartment of Cardiology, Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli, 80131 Naples, ItalyDepartment of Radiology, Ospedale del Mare-ASL Napoli 1, 80147 Naples, ItalyDepartment of Radiology, San Giovanni Bosco-ASL Napoli 1, 80144 Naples, Italy<b>Objectives:</b> Our study aims to investigate the correlation between epicardial adipose tissue (EAT) volume assessed with non-contrast cardiac CT (NCCCT) and sex, age, coronary artery disease reporting and data system (CAD-RADS 2.0) categories, and coronary artery calcification (CAC) extent. The secondary aim is to establish the average values of EAT in a population considered healthy for coronary artery disease (CAD). <b>Materials and Methods:</b> We retrospectively analyzed patients who underwent coronary computed tomography angiography (CCTA) at our institution from January 2023 to August 2024. The CAD-RADS 2.0 scoring system was applied to assess the extent of CAD; CAC extent was quantified according to the Agatston score. EAT was segmented semi-automatically in NCCCT images, and its volume was subsequently measured. Correlation analyses between EAT volume, sex, patient age, CAC, and CAD-RADS categories were conducted. <b>Results:</b> A total of 489 consecutive patients met the inclusion criteria (63.96 ± 12.18 years; 214 females). The mean EAT volume ± SD in those categorized as CAD-RADS 0 (57.25 ± 15.45 years, 120 patients) was 117.43 ± 50.30 cm<sup>3</sup>: values were higher in men (121.07 ± 53.31 cm<sup>3</sup>) than in women (114.54 ± 47.98 cm<sup>3</sup>). EAT volumes positively correlated with age, male sex, CAD severity, and CAC scores. <b>Conclusions:</b> According to our results, males in all CAD-RADS categories have a greater amount of EAT than females. A positive correlation between the volume of EAT and factors such as age (<i>p</i> = 0.003), CAD-RADS categories (<i>p</i>: 0.004), and coronary calcium score (<i>p</i> = 0.0001) with a strong influence exerted by sex was demonstrated. Our results reinforce the observation that higher EAT volumes are associated with a more severe coronary artery disease.https://www.mdpi.com/2075-4418/15/6/681epicardial adipose tissue (EAT)coronary computed tomography angiography (CCTA)coronary artery disease reporting and data system (CAD-RADS)coronary artery disease (CAD)coronary artery calcification (CAC) |
| spellingShingle | Federica Dell’Aversana Renato Tuccillo Alessandro Monfregola Leda De Angelis Giovanni Ferrandino Carlo Tedeschi Fulvio Cacciapuoti Fabio Tamburro Carlo Liguori Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CT Diagnostics epicardial adipose tissue (EAT) coronary computed tomography angiography (CCTA) coronary artery disease reporting and data system (CAD-RADS) coronary artery disease (CAD) coronary artery calcification (CAC) |
| title | Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CT |
| title_full | Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CT |
| title_fullStr | Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CT |
| title_full_unstemmed | Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CT |
| title_short | Epicardial Adipose Tissue Volume Assessment in the General Population and CAD-RADS 2.0 Score Correlation Using Dual Source Cardiac CT |
| title_sort | epicardial adipose tissue volume assessment in the general population and cad rads 2 0 score correlation using dual source cardiac ct |
| topic | epicardial adipose tissue (EAT) coronary computed tomography angiography (CCTA) coronary artery disease reporting and data system (CAD-RADS) coronary artery disease (CAD) coronary artery calcification (CAC) |
| url | https://www.mdpi.com/2075-4418/15/6/681 |
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