Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal
Abstract Osteoporosis, a metabolic disorder, remains challenging to treat due to limited understanding of its underlying mechanism. The annual cycle of “cyclic physiological osteoporosis (CPO)” and its full reversal in male deer represents a unique natural model for studying this condition. Deer ant...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Biology Direct |
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| Online Access: | https://doi.org/10.1186/s13062-024-00561-3 |
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| _version_ | 1846148024121688064 |
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| author | Chunyi Li Wenying Wang Guokun Zhang Hengxing Ba He Liu Jincheng Wang Wei Li Gerry Melino Yufang Shi |
| author_facet | Chunyi Li Wenying Wang Guokun Zhang Hengxing Ba He Liu Jincheng Wang Wei Li Gerry Melino Yufang Shi |
| author_sort | Chunyi Li |
| collection | DOAJ |
| description | Abstract Osteoporosis, a metabolic disorder, remains challenging to treat due to limited understanding of its underlying mechanism. The annual cycle of “cyclic physiological osteoporosis (CPO)” and its full reversal in male deer represents a unique natural model for studying this condition. Deer antlers, weighing up to 25 kg/pair, derive over 60% of their mineral contents from deer skeleton during mineralization. Based on the literature, we propose to divide CPO and its reversal into two phases: Phase I (approximately 115 days): from hard antler casting to the end of antler linear growth, marked by simultaneous robust antler ossification and CPO development; and Phase II (up to 165 days): from end of Phase I to the onset of antler skin shedding, characterized by complete antler mineralization and CPO reversal. This review analyzes the paradoxical occurrence of robust antler ossification and skeleton CPO within the same endocrine microenvironment during phase I; total antler mineralization and full reversal of deer skeleton CPO in phase II. Furthermore, we will discuss potential insights for osteoporosis treatment using deer materials from the period of Phase II. Our goal is to identify novel substances and therapies that could be applied in clinical setting to effectively treat osteoporosis. |
| format | Article |
| id | doaj-art-4319bcef7f2446c1a9c814faae915730 |
| institution | Kabale University |
| issn | 1745-6150 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj-art-4319bcef7f2446c1a9c814faae9157302024-12-01T12:13:39ZengBMCBiology Direct1745-61502024-11-0119111310.1186/s13062-024-00561-3Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversalChunyi Li0Wenying Wang1Guokun Zhang2Hengxing Ba3He Liu4Jincheng Wang5Wei Li6Gerry Melino7Yufang Shi8Institute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityInstitute of Antler Science and Product Technology, Changchun Sci-Tech UniversityDepartment of Orthopedics, The Second Hospital of Jilin UniversityDepartment of Orthopedics, The Second Hospital of Jilin UniversityCollege of Life Sciences, Jilin Agricultural UniversityDepartment of Experimental Medicine and Biochemical Sciences, University of Rome Tor VergataState Key Laboratory of Radiation Medicine and Protection, Medical College, The Third Affiliated Hospital of Soochow University, The First People’s Hospital of Changzhou, Institutes for Translational Medicine of Soochow UniversityAbstract Osteoporosis, a metabolic disorder, remains challenging to treat due to limited understanding of its underlying mechanism. The annual cycle of “cyclic physiological osteoporosis (CPO)” and its full reversal in male deer represents a unique natural model for studying this condition. Deer antlers, weighing up to 25 kg/pair, derive over 60% of their mineral contents from deer skeleton during mineralization. Based on the literature, we propose to divide CPO and its reversal into two phases: Phase I (approximately 115 days): from hard antler casting to the end of antler linear growth, marked by simultaneous robust antler ossification and CPO development; and Phase II (up to 165 days): from end of Phase I to the onset of antler skin shedding, characterized by complete antler mineralization and CPO reversal. This review analyzes the paradoxical occurrence of robust antler ossification and skeleton CPO within the same endocrine microenvironment during phase I; total antler mineralization and full reversal of deer skeleton CPO in phase II. Furthermore, we will discuss potential insights for osteoporosis treatment using deer materials from the period of Phase II. Our goal is to identify novel substances and therapies that could be applied in clinical setting to effectively treat osteoporosis.https://doi.org/10.1186/s13062-024-00561-3Osteoporosis reversalDeer skeletonDeer antlerBone formationBone resorption |
| spellingShingle | Chunyi Li Wenying Wang Guokun Zhang Hengxing Ba He Liu Jincheng Wang Wei Li Gerry Melino Yufang Shi Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal Biology Direct Osteoporosis reversal Deer skeleton Deer antler Bone formation Bone resorption |
| title | Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal |
| title_full | Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal |
| title_fullStr | Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal |
| title_full_unstemmed | Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal |
| title_short | Bone metabolism associated with annual antler regeneration: a deer insight into osteoporosis reversal |
| title_sort | bone metabolism associated with annual antler regeneration a deer insight into osteoporosis reversal |
| topic | Osteoporosis reversal Deer skeleton Deer antler Bone formation Bone resorption |
| url | https://doi.org/10.1186/s13062-024-00561-3 |
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