The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients
<b>Aim/Objectives</b>: To investigate whether frailty predicts adherence to psychotropic drug treatment or adverse drug reactions, within 6 months after treatment initiation. <b>Methods</b>: A prospective cohort study including 77 patients over the age of 65, treated in one l...
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MDPI AG
2025-04-01
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| Series: | Geriatrics |
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| author | Tuan Anh Phan Rob Kok |
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| collection | DOAJ |
| description | <b>Aim/Objectives</b>: To investigate whether frailty predicts adherence to psychotropic drug treatment or adverse drug reactions, within 6 months after treatment initiation. <b>Methods</b>: A prospective cohort study including 77 patients over the age of 65, treated in one large psychiatric institute in the Netherlands. Patients were assessed at baseline for their frailty status, using different operationalizations of the Fried frailty criteria. Data on duration of psychotropic drug treatment and number of reported adverse drug reactions were retrieved from electronic patient files. Regression analyses were adjusted for age, sex, patient setting, and polypharmacy as potential confounders. <b>Results</b>: Frail patients were not significantly more likely to discontinue psychotropic treatment than non-frail patients (OR = 1.4; 95% CI 0.6–3.7, <i>p</i> = 0.468). Time to treatment discontinuation was also not statistically different between both study groups (HR = 0.8; 95% CI 0.4–1.6, <i>p</i> = 0.498), and neither was the number of adverse drug reactions (OR = 1.6, 95% CI 0.6–4.1, <i>p</i> = 0.345). <b>Conclusions</b>: We could not demonstrate a statistically significant effect of frailty as predictor of discontinuing psychotropic treatment or adverse drug reactions, but a lack of power may also explain our results. A more comprehensive frailty assessment may be needed to predict treatment adherence or adverse drug reactions in psychiatric patients. |
| format | Article |
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| language | English |
| publishDate | 2025-04-01 |
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| series | Geriatrics |
| spelling | doaj-art-4319b6e9b7a645de9fe5a0dd6660582a2025-08-20T02:28:23ZengMDPI AGGeriatrics2308-34172025-04-011025710.3390/geriatrics10020057The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric PatientsTuan Anh Phan0Rob Kok1Erasmus Medical Center, Hospital Pharmacy, Dr. Molewaterplein 40, 3015 GD Rotterdam, The NetherlandsParnassia Group, Department of Old Age Psychiatry, Mangostraat 1, 2552 KS Den Haag, The Netherlands<b>Aim/Objectives</b>: To investigate whether frailty predicts adherence to psychotropic drug treatment or adverse drug reactions, within 6 months after treatment initiation. <b>Methods</b>: A prospective cohort study including 77 patients over the age of 65, treated in one large psychiatric institute in the Netherlands. Patients were assessed at baseline for their frailty status, using different operationalizations of the Fried frailty criteria. Data on duration of psychotropic drug treatment and number of reported adverse drug reactions were retrieved from electronic patient files. Regression analyses were adjusted for age, sex, patient setting, and polypharmacy as potential confounders. <b>Results</b>: Frail patients were not significantly more likely to discontinue psychotropic treatment than non-frail patients (OR = 1.4; 95% CI 0.6–3.7, <i>p</i> = 0.468). Time to treatment discontinuation was also not statistically different between both study groups (HR = 0.8; 95% CI 0.4–1.6, <i>p</i> = 0.498), and neither was the number of adverse drug reactions (OR = 1.6, 95% CI 0.6–4.1, <i>p</i> = 0.345). <b>Conclusions</b>: We could not demonstrate a statistically significant effect of frailty as predictor of discontinuing psychotropic treatment or adverse drug reactions, but a lack of power may also explain our results. A more comprehensive frailty assessment may be needed to predict treatment adherence or adverse drug reactions in psychiatric patients.https://www.mdpi.com/2308-3417/10/2/57frailtypsychiatric patientspsychotropic drugstreatment adherenceadverse drug reactions |
| spellingShingle | Tuan Anh Phan Rob Kok The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients Geriatrics frailty psychiatric patients psychotropic drugs treatment adherence adverse drug reactions |
| title | The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients |
| title_full | The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients |
| title_fullStr | The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients |
| title_full_unstemmed | The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients |
| title_short | The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients |
| title_sort | influence of frailty on pharmacotherapy adherence and adverse drug reactions in older psychiatric patients |
| topic | frailty psychiatric patients psychotropic drugs treatment adherence adverse drug reactions |
| url | https://www.mdpi.com/2308-3417/10/2/57 |
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