Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects
Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endo...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/4837930 |
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| author | Olena Pogozhykh Volodymyr Prokopyuk Constança Figueiredo Denys Pogozhykh |
| author_facet | Olena Pogozhykh Volodymyr Prokopyuk Constança Figueiredo Denys Pogozhykh |
| author_sort | Olena Pogozhykh |
| collection | DOAJ |
| description | Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and the ability to invasion and deportation are discussed. These features are considered from a perspective that determines the placental material as a unique source for regenerative cell therapies and a lesson for immunological tolerance. A historical overview of clinical applications of placental extracts, cells, and tissue components is described. Empirically accumulated data are summarized and compared with modern research. Furthermore, we define scopes and outlooks of application of placental cells and tissues in the rapidly progressing field of regenerative medicine. |
| format | Article |
| id | doaj-art-43158e5bfaf744a8961a45e05a8f7fca |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-43158e5bfaf744a8961a45e05a8f7fca2025-08-20T03:35:58ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/48379304837930Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and ProspectsOlena Pogozhykh0Volodymyr Prokopyuk1Constança Figueiredo2Denys Pogozhykh3Institute for Transfusion Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, GermanyInstitute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, Pereyaslavskaya Str. 23, Kharkov 61015, UkraineInstitute for Transfusion Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, GermanyInstitute for Transfusion Medicine, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, GermanyPlacental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and the ability to invasion and deportation are discussed. These features are considered from a perspective that determines the placental material as a unique source for regenerative cell therapies and a lesson for immunological tolerance. A historical overview of clinical applications of placental extracts, cells, and tissue components is described. Empirically accumulated data are summarized and compared with modern research. Furthermore, we define scopes and outlooks of application of placental cells and tissues in the rapidly progressing field of regenerative medicine.http://dx.doi.org/10.1155/2018/4837930 |
| spellingShingle | Olena Pogozhykh Volodymyr Prokopyuk Constança Figueiredo Denys Pogozhykh Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects Stem Cells International |
| title | Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects |
| title_full | Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects |
| title_fullStr | Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects |
| title_full_unstemmed | Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects |
| title_short | Placenta and Placental Derivatives in Regenerative Therapies: Experimental Studies, History, and Prospects |
| title_sort | placenta and placental derivatives in regenerative therapies experimental studies history and prospects |
| url | http://dx.doi.org/10.1155/2018/4837930 |
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