Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes?
The immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). However, not much is known about the role of the immune system and specifically T-cells in the onset and maintenance of this disease. In this study, we aimed to evaluate T-cell act...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/2764261 |
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| author | Krishna D. Bharwani Maaike Dirckx Dirk L. Stronks Willem A. Dik Marco W. J. Schreurs Frank J. P. M. Huygen |
| author_facet | Krishna D. Bharwani Maaike Dirckx Dirk L. Stronks Willem A. Dik Marco W. J. Schreurs Frank J. P. M. Huygen |
| author_sort | Krishna D. Bharwani |
| collection | DOAJ |
| description | The immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). However, not much is known about the role of the immune system and specifically T-cells in the onset and maintenance of this disease. In this study, we aimed to evaluate T-cell activity in CRPS by comparing blood soluble interleukin-2 receptor (sIL-2R) levels between CRPS patients and healthy controls. CRPS patients had statistically significant elevated levels of sIL-2R as compared to healthy controls (median sIL-2R levels: 4151 pg/ml (Q3 − Q1 = 5731 pg/ml − 3546 pg/ml) versus 1907 pg/ml (Q3 − Q1: 2206 pg/ml − 1374 pg/ml), p<0.001, resp.). Furthermore, sIL-2R level seems to be a good discriminator between CRPS patients and healthy controls with a high sensitivity (90%) and specificity (89.5%). Our finding indicates increased T-cell activity in patients with CRPS. This finding is of considerable relevance as it could point towards a T-cell-mediated inflammatory process in this disease. This could pave the way for new anti-inflammatory therapies in the treatment of CRPS. Furthermore, sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS. |
| format | Article |
| id | doaj-art-431562a14da74f5ea9d6b6a295cf9fc0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-431562a14da74f5ea9d6b6a295cf9fc02025-02-03T06:14:15ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/27642612764261Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes?Krishna D. Bharwani0Maaike Dirckx1Dirk L. Stronks2Willem A. Dik3Marco W. J. Schreurs4Frank J. P. M. Huygen5Center for Pain Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, NetherlandsCenter for Pain Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, NetherlandsCenter for Pain Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, NetherlandsDepartment of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, NetherlandsCenter for Pain Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, NetherlandsThe immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). However, not much is known about the role of the immune system and specifically T-cells in the onset and maintenance of this disease. In this study, we aimed to evaluate T-cell activity in CRPS by comparing blood soluble interleukin-2 receptor (sIL-2R) levels between CRPS patients and healthy controls. CRPS patients had statistically significant elevated levels of sIL-2R as compared to healthy controls (median sIL-2R levels: 4151 pg/ml (Q3 − Q1 = 5731 pg/ml − 3546 pg/ml) versus 1907 pg/ml (Q3 − Q1: 2206 pg/ml − 1374 pg/ml), p<0.001, resp.). Furthermore, sIL-2R level seems to be a good discriminator between CRPS patients and healthy controls with a high sensitivity (90%) and specificity (89.5%). Our finding indicates increased T-cell activity in patients with CRPS. This finding is of considerable relevance as it could point towards a T-cell-mediated inflammatory process in this disease. This could pave the way for new anti-inflammatory therapies in the treatment of CRPS. Furthermore, sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS.http://dx.doi.org/10.1155/2017/2764261 |
| spellingShingle | Krishna D. Bharwani Maaike Dirckx Dirk L. Stronks Willem A. Dik Marco W. J. Schreurs Frank J. P. M. Huygen Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? Mediators of Inflammation |
| title | Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? |
| title_full | Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? |
| title_fullStr | Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? |
| title_full_unstemmed | Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? |
| title_short | Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? |
| title_sort | elevated plasma levels of sil 2r in complex regional pain syndrome a pathogenic role for t lymphocytes |
| url | http://dx.doi.org/10.1155/2017/2764261 |
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