3-Hydroxy-3-methylglutaryl-CoA reductase variants strongly associated with low-density lipoprotein cholesterol levels and diabetes mellitus risk in a Taiwanese population: A Mendelian randomization study

3-Hydroxy-3-methylglutaryl-CoA reductase variants strongly associated with low-density lipoprotein cholesterol levels and diabetes mellitus risk in a Taiwanese population: A Mendelian randomization study

Objectives: 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a rate-limiting enzyme involved in cholesterol synthesis. The common HMGCR variants are associated with low-density lipoprotein cholesterol (LDL-C) levels. We aimed to identify novel HMGCR variants influencing the lipid profiles of Taiw...

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Bibliographic Details
Main Authors:	Lung-An Hsu, Ming-Sheng Teng, De-Min Duan, Kuan-Hung Yeh, Semon Wu, Yu-Lin Ko
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-04-01
Series:	Tzu Chi Medical Journal
Subjects:	3-hydroxy-3-methylglutaryl-coa reductase diabetes mellitus low-density lipoprotein cholesterol mendelian randomization nonsynonymous mutation
Online Access:	https://journals.lww.com/10.4103/tcmj.tcmj_247_24
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