Cefepime-induced neurotoxicity
We present a case of severe cefepime-induced neurotoxicity following acute kidney injury in a patient with a fracture-related infection. Despite stopping cefepime, the patient required intubation, ventilation, multiple antiepileptic drugs for seizure control, and haemodialysis. Contribution: Cefepi...
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| Format: | Article |
| Language: | English |
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AOSIS
2025-04-01
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| Series: | Southern African Journal of Infectious Diseases |
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| Online Access: | https://sajid.co.za/index.php/sajid/article/view/704 |
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| _version_ | 1849323823154855936 |
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| author | Jessica Taylor Hannah M. Gunter Karen Cohen |
| author_facet | Jessica Taylor Hannah M. Gunter Karen Cohen |
| author_sort | Jessica Taylor |
| collection | DOAJ |
| description | We present a case of severe cefepime-induced neurotoxicity following acute kidney injury in a patient with a fracture-related infection. Despite stopping cefepime, the patient required intubation, ventilation, multiple antiepileptic drugs for seizure control, and haemodialysis.
Contribution: Cefepime-induced neurotoxicity is a reversible cause of encephalopathy. Early recognition and cefepime withdrawal are crucial. As cefepime use in South Africa increases due to antimicrobial resistance, healthcare workers must be aware of this under-recognised, under-reported serious adverse drug reaction. |
| format | Article |
| id | doaj-art-430935eecbea45faa72b2e8113359541 |
| institution | Kabale University |
| issn | 2312-0053 2313-1810 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | AOSIS |
| record_format | Article |
| series | Southern African Journal of Infectious Diseases |
| spelling | doaj-art-430935eecbea45faa72b2e81133595412025-08-20T03:48:53ZengAOSISSouthern African Journal of Infectious Diseases2312-00532313-18102025-04-01401e1e410.4102/sajid.v40i1.704341Cefepime-induced neurotoxicityJessica Taylor0Hannah M. Gunter1Karen Cohen2Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape TownDivision of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape TownDivision of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape TownWe present a case of severe cefepime-induced neurotoxicity following acute kidney injury in a patient with a fracture-related infection. Despite stopping cefepime, the patient required intubation, ventilation, multiple antiepileptic drugs for seizure control, and haemodialysis. Contribution: Cefepime-induced neurotoxicity is a reversible cause of encephalopathy. Early recognition and cefepime withdrawal are crucial. As cefepime use in South Africa increases due to antimicrobial resistance, healthcare workers must be aware of this under-recognised, under-reported serious adverse drug reaction.https://sajid.co.za/index.php/sajid/article/view/704cefepimeneurotoxicitycefepime-induced neurotoxicityadverse drug reactionencephalopathy |
| spellingShingle | Jessica Taylor Hannah M. Gunter Karen Cohen Cefepime-induced neurotoxicity Southern African Journal of Infectious Diseases cefepime neurotoxicity cefepime-induced neurotoxicity adverse drug reaction encephalopathy |
| title | Cefepime-induced neurotoxicity |
| title_full | Cefepime-induced neurotoxicity |
| title_fullStr | Cefepime-induced neurotoxicity |
| title_full_unstemmed | Cefepime-induced neurotoxicity |
| title_short | Cefepime-induced neurotoxicity |
| title_sort | cefepime induced neurotoxicity |
| topic | cefepime neurotoxicity cefepime-induced neurotoxicity adverse drug reaction encephalopathy |
| url | https://sajid.co.za/index.php/sajid/article/view/704 |
| work_keys_str_mv | AT jessicataylor cefepimeinducedneurotoxicity AT hannahmgunter cefepimeinducedneurotoxicity AT karencohen cefepimeinducedneurotoxicity |