One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration
Purpose. To evaluate the effects of photodynamic therapy (PDT) combined with intravitreal injection of ranibizumab (IVR) for exudative age-related macular degeneration (AMD). Methods. Retrospective case series. Thirty eight eyes of 38 patients with exudative AMD underwent combined therapy consisting...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/154659 |
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| author | Tomoko Nakamura Akio Miyakoshi Kazuya Fujita Tatsuya Yunoki Keiichi Mitarai Shuichiro Yanagisawa Chiharu Fuchizawa Atsushi Hayashi |
| author_facet | Tomoko Nakamura Akio Miyakoshi Kazuya Fujita Tatsuya Yunoki Keiichi Mitarai Shuichiro Yanagisawa Chiharu Fuchizawa Atsushi Hayashi |
| author_sort | Tomoko Nakamura |
| collection | DOAJ |
| description | Purpose. To evaluate the effects of photodynamic therapy (PDT) combined with intravitreal injection of ranibizumab (IVR) for exudative age-related macular degeneration (AMD). Methods. Retrospective case series. Thirty eight eyes of 38 patients with exudative AMD underwent combined therapy consisting first of IVR, followed by PDT within a week and the second IVR at 1 month. All patients were followed up for more than 12 months. The best corrected visual acuity (BCVA) and central macular thickness (CMT) were examined. Results. The mean number of IVR and PDT sessions were 2.9±1.3 and 1.1±0.3, respectively. The mean BCVA and CMT were significantly improved to 0.38 logMAR units (𝑃<0.01) and 240 μm (𝑃<0.01) at 12 months, respectively. Thirty-six of 38 eyes (94.8%) improved or maintained BCVA at 12 months. Conclusion. PDT combined with IVR for exudative AMD was effective at improving visual acuity and CMT with a low recurrence rate for 12 months. |
| format | Article |
| id | doaj-art-4308f2b36cc548d092aeda3508212ae7 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-4308f2b36cc548d092aeda3508212ae72025-08-20T03:35:54ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/154659154659One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular DegenerationTomoko Nakamura0Akio Miyakoshi1Kazuya Fujita2Tatsuya Yunoki3Keiichi Mitarai4Shuichiro Yanagisawa5Chiharu Fuchizawa6Atsushi Hayashi7Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, JapanPurpose. To evaluate the effects of photodynamic therapy (PDT) combined with intravitreal injection of ranibizumab (IVR) for exudative age-related macular degeneration (AMD). Methods. Retrospective case series. Thirty eight eyes of 38 patients with exudative AMD underwent combined therapy consisting first of IVR, followed by PDT within a week and the second IVR at 1 month. All patients were followed up for more than 12 months. The best corrected visual acuity (BCVA) and central macular thickness (CMT) were examined. Results. The mean number of IVR and PDT sessions were 2.9±1.3 and 1.1±0.3, respectively. The mean BCVA and CMT were significantly improved to 0.38 logMAR units (𝑃<0.01) and 240 μm (𝑃<0.01) at 12 months, respectively. Thirty-six of 38 eyes (94.8%) improved or maintained BCVA at 12 months. Conclusion. PDT combined with IVR for exudative AMD was effective at improving visual acuity and CMT with a low recurrence rate for 12 months.http://dx.doi.org/10.1155/2012/154659 |
| spellingShingle | Tomoko Nakamura Akio Miyakoshi Kazuya Fujita Tatsuya Yunoki Keiichi Mitarai Shuichiro Yanagisawa Chiharu Fuchizawa Atsushi Hayashi One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration Journal of Ophthalmology |
| title | One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration |
| title_full | One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration |
| title_fullStr | One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration |
| title_full_unstemmed | One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration |
| title_short | One-Year Results of Photodynamic Therapy Combined with Intravitreal Ranibizumab for Exudative Age-Related Macular Degeneration |
| title_sort | one year results of photodynamic therapy combined with intravitreal ranibizumab for exudative age related macular degeneration |
| url | http://dx.doi.org/10.1155/2012/154659 |
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