Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease
Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Ob...
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Dove Medical Press
2016-08-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/aberrant-brain-stem-morphometry-associated-with-sleep-disturbance-in-d-peer-reviewed-fulltext-article-NDT |
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| author | Lee JH Jung WS Choi WH Lim H |
| author_facet | Lee JH Jung WS Choi WH Lim H |
| author_sort | Lee JH |
| collection | DOAJ |
| description | Ji Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD), sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysis |
| format | Article |
| id | doaj-art-4307a339849c4aed975655efc3fe54a6 |
| institution | Kabale University |
| issn | 1178-2021 |
| language | English |
| publishDate | 2016-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-4307a339849c4aed975655efc3fe54a62025-08-20T03:27:01ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212016-08-01Volume 12Issue 12089209328546Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's diseaseLee JHJung WSChoi WHLim H0Department of PsychiatryJi Han Lee,1 Won Sang Jung,2 Woo Hee Choi,3 Hyun Kook Lim4 1Washington University in St Louis, St Louis, MO, USA; 2Department of Radiology, 3Department of Nuclear Medicine, 4Department of Psychiatry, Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea Objective: Among patients with Alzheimer’s disease (AD), sleep disturbances are common and serious noncognitive symptoms. Previous studies of AD patients have identified deformations in the brain stem, which may play an important role in the regulation of sleep. The aim of this study was to further investigate the relationship between sleep disturbances and alterations in brain stem morphology in AD.Materials and methods: In 44 patients with AD and 40 healthy elderly controls, sleep disturbances were measured using the Neuropsychiatry Inventory sleep subscale. We employed magnetic resonance imaging-based automated segmentation tools to examine the relationship between sleep disturbances and changes in brain stem morphology.Results: Analyses of the data from AD subjects revealed significant correlations between the Neuropsychiatry Inventory sleep-subscale scores and structural alterations in the left posterior lateral region of the brain stem, as well as normalized brain stem volumes. In addition, significant group differences in posterior brain stem morphology were observed between the AD group and the control group.Conclusion: This study is the first to analyze an association between sleep disturbances and brain stem morphology in AD. In line with previous findings, this study lends support to the possibility that brain stem structural abnormalities might be important neurobiological mechanisms underlying sleep disturbances associated with AD. Further longitudinal research is needed to confirm these findings. Keywords: Alzheimer’s disease, sleep, brain stem, MRI, shape analysishttps://www.dovepress.com/aberrant-brain-stem-morphometry-associated-with-sleep-disturbance-in-d-peer-reviewed-fulltext-article-NDTAlzheimer’s diseasesleepbrainstemMRIshape analysis |
| spellingShingle | Lee JH Jung WS Choi WH Lim H Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease Neuropsychiatric Disease and Treatment Alzheimer’s disease sleep brainstem MRI shape analysis |
| title | Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease |
| title_full | Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease |
| title_fullStr | Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease |
| title_full_unstemmed | Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease |
| title_short | Aberrant brain-stem morphometry associated with sleep disturbance in drug-naïve subjects with Alzheimer's disease |
| title_sort | aberrant brain stem morphometry associated with sleep disturbance in drug na amp iuml ve subjects with alzheimer amp 39 s disease |
| topic | Alzheimer’s disease sleep brainstem MRI shape analysis |
| url | https://www.dovepress.com/aberrant-brain-stem-morphometry-associated-with-sleep-disturbance-in-d-peer-reviewed-fulltext-article-NDT |
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