Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib
Reversible posterior leukoencephalopathy syndrome (RPLS) is clinical radiologic condition associated with neurological symptoms and cerebral white matter edema. It has been associated with uncontrolled hypertension, eclampsia, immunosuppressants, and more recently the use of antiangiogenic drugs. Su...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/952624 |
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| _version_ | 1849407935993610240 |
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| author | Ricardo Costa Rubens Costa Renata Costa Gilberto Moura de Brito Junior Henrique Queiroz Cartaxo Alex Caetano de Barros |
| author_facet | Ricardo Costa Rubens Costa Renata Costa Gilberto Moura de Brito Junior Henrique Queiroz Cartaxo Alex Caetano de Barros |
| author_sort | Ricardo Costa |
| collection | DOAJ |
| description | Reversible posterior leukoencephalopathy syndrome (RPLS) is clinical radiologic condition associated with neurological symptoms and cerebral white matter edema. It has been associated with uncontrolled hypertension, eclampsia, immunosuppressants, and more recently the use of antiangiogenic drugs. Sunitinib is an inhibitor of the vascular endothelial growth factor receptor widely used in the treatment of metastatic renal cell carcinoma (RCC). We report a rare case of RPLS occurring on therapy with sunitinib in a patient with RCC. Our aim is to highlight the importance of considering RPLS as a diagnostic possibility and to hold sunitinib for RCC patients presenting with neurologic symptoms. |
| format | Article |
| id | doaj-art-4305e30abd2a441eb56b365516f9af16 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-4305e30abd2a441eb56b365516f9af162025-08-20T03:35:54ZengWileyCase Reports in Oncological Medicine2090-67062090-67142014-01-01201410.1155/2014/952624952624Reversible Posterior Encephalopathy Syndrome Secondary to SunitinibRicardo Costa0Rubens Costa1Renata Costa2Gilberto Moura de Brito Junior3Henrique Queiroz Cartaxo4Alex Caetano de Barros5Department of Oncology, Real Hospital Portugues, 52010 Recife, PE, BrazilCedar Valley Cancer Center, Waterloo, IA 50701, USAAmerican University of the Caribbean, Coral Gables, FL 33134, USADepartment of Radiology, Real Hospital Portugues, 52010 Recife, PE, BrazilDepartment of Radiology, Real Hospital Portugues, 52010 Recife, PE, BrazilDepartment of Neurosurgery, Real Hospital Portugues, 52010 Recife, PE, BrazilReversible posterior leukoencephalopathy syndrome (RPLS) is clinical radiologic condition associated with neurological symptoms and cerebral white matter edema. It has been associated with uncontrolled hypertension, eclampsia, immunosuppressants, and more recently the use of antiangiogenic drugs. Sunitinib is an inhibitor of the vascular endothelial growth factor receptor widely used in the treatment of metastatic renal cell carcinoma (RCC). We report a rare case of RPLS occurring on therapy with sunitinib in a patient with RCC. Our aim is to highlight the importance of considering RPLS as a diagnostic possibility and to hold sunitinib for RCC patients presenting with neurologic symptoms.http://dx.doi.org/10.1155/2014/952624 |
| spellingShingle | Ricardo Costa Rubens Costa Renata Costa Gilberto Moura de Brito Junior Henrique Queiroz Cartaxo Alex Caetano de Barros Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib Case Reports in Oncological Medicine |
| title | Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib |
| title_full | Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib |
| title_fullStr | Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib |
| title_full_unstemmed | Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib |
| title_short | Reversible Posterior Encephalopathy Syndrome Secondary to Sunitinib |
| title_sort | reversible posterior encephalopathy syndrome secondary to sunitinib |
| url | http://dx.doi.org/10.1155/2014/952624 |
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