Eosinophilic Angiocentric Fibrosis of the Nasal Septum
Background. Eosinophilic angiocentric fibrosis (EAF) is a rare benign condition of unknown aetiology that causes stenosis of the upper respiratory tract. It is most commonly found at the nasal septum and sinus mucosa causing mucosal thickening and nasal obstructive symptoms. The diagnosis is mainly...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2013/267285 |
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| author | Yunchuan Li Honggang Liu Demin Han Hongrui Zang Tong Wang Bin Hu |
| author_facet | Yunchuan Li Honggang Liu Demin Han Hongrui Zang Tong Wang Bin Hu |
| author_sort | Yunchuan Li |
| collection | DOAJ |
| description | Background. Eosinophilic angiocentric fibrosis (EAF) is a rare benign condition of unknown aetiology that causes stenosis of the upper respiratory tract. It is most commonly found at the nasal septum and sinus mucosa causing mucosal thickening and nasal obstructive symptoms. The diagnosis is mainly based on characteristic histologic findings. Case Report. A 27-year-old young woman presented with a slow growing mass at her anterior nasal septum for over eight years. She complained of persistent nasal obstruction, epistaxis, sometimes diffused facial pain, and chronic headache. 3 years ago, the tumor was partially resected for ventilation and a nasal septum perforation was left. Imaging findings indicated soft-tissue thickening of the anterior part of septum and adjacent lateral nasal walls. Pathological examination showed numerous inflammatory cells infiltrates containing eosinophils, fibroinflammatory lesion with a whorled appearance fibrosis which typically surrounded vessels. A diagnosis of eosinophilic angiocentric fibrosis was made. All laboratory tests were unremarkable. Skin prick test was positive. The tumor-like lesion was totally resected. Conclusions. EAF is a rare benign and progressive disorder causing destruction. Combined with radiological imaging of EAF historical findings contribute to the diagnosis. It is important to prevent tumor from recurrence by total resection of the lesion. |
| format | Article |
| id | doaj-art-42feace3ec284a989e4a8ee2ff28b119 |
| institution | Kabale University |
| issn | 2090-6765 2090-6773 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-42feace3ec284a989e4a8ee2ff28b1192025-08-20T03:35:57ZengWileyCase Reports in Otolaryngology2090-67652090-67732013-01-01201310.1155/2013/267285267285Eosinophilic Angiocentric Fibrosis of the Nasal SeptumYunchuan Li0Honggang Liu1Demin Han2Hongrui Zang3Tong Wang4Bin Hu5Department of Otolaryngology, The Key Discipline of Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology, The Key Discipline of Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology, The Key Discipline of Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology, The Key Discipline of Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaDepartment of Otolaryngology, The Key Discipline of Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, ChinaBackground. Eosinophilic angiocentric fibrosis (EAF) is a rare benign condition of unknown aetiology that causes stenosis of the upper respiratory tract. It is most commonly found at the nasal septum and sinus mucosa causing mucosal thickening and nasal obstructive symptoms. The diagnosis is mainly based on characteristic histologic findings. Case Report. A 27-year-old young woman presented with a slow growing mass at her anterior nasal septum for over eight years. She complained of persistent nasal obstruction, epistaxis, sometimes diffused facial pain, and chronic headache. 3 years ago, the tumor was partially resected for ventilation and a nasal septum perforation was left. Imaging findings indicated soft-tissue thickening of the anterior part of septum and adjacent lateral nasal walls. Pathological examination showed numerous inflammatory cells infiltrates containing eosinophils, fibroinflammatory lesion with a whorled appearance fibrosis which typically surrounded vessels. A diagnosis of eosinophilic angiocentric fibrosis was made. All laboratory tests were unremarkable. Skin prick test was positive. The tumor-like lesion was totally resected. Conclusions. EAF is a rare benign and progressive disorder causing destruction. Combined with radiological imaging of EAF historical findings contribute to the diagnosis. It is important to prevent tumor from recurrence by total resection of the lesion.http://dx.doi.org/10.1155/2013/267285 |
| spellingShingle | Yunchuan Li Honggang Liu Demin Han Hongrui Zang Tong Wang Bin Hu Eosinophilic Angiocentric Fibrosis of the Nasal Septum Case Reports in Otolaryngology |
| title | Eosinophilic Angiocentric Fibrosis of the Nasal Septum |
| title_full | Eosinophilic Angiocentric Fibrosis of the Nasal Septum |
| title_fullStr | Eosinophilic Angiocentric Fibrosis of the Nasal Septum |
| title_full_unstemmed | Eosinophilic Angiocentric Fibrosis of the Nasal Septum |
| title_short | Eosinophilic Angiocentric Fibrosis of the Nasal Septum |
| title_sort | eosinophilic angiocentric fibrosis of the nasal septum |
| url | http://dx.doi.org/10.1155/2013/267285 |
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