In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levels
Background: Continuous UVB exposure induces lipid peroxidation and inflammation, with Malondialdehyde (MDA) as an indicator, leading to interleukin-6 (IL-6) secretion. Astaxanthin, a powerful antioxidant, is 50-100 times stronger than vitamin C, but its effects on MDA and IL-6 in UVB exposed skin ha...
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| Format: | Article |
| Language: | English |
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Universitas Muhammadiyah Purwokerto
2025-04-01
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| Series: | Medisains |
| Online Access: | https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/24667 |
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| author | Rudy Ekofitranto Siti Thomas Zulaikhah Joko Wahyu Wibowo |
| author_facet | Rudy Ekofitranto Siti Thomas Zulaikhah Joko Wahyu Wibowo |
| author_sort | Rudy Ekofitranto |
| collection | DOAJ |
| description | Background: Continuous UVB exposure induces lipid peroxidation and inflammation, with Malondialdehyde (MDA) as an indicator, leading to interleukin-6 (IL-6) secretion. Astaxanthin, a powerful antioxidant, is 50-100 times stronger than vitamin C, but its effects on MDA and IL-6 in UVB exposed skin have not been studied.
Objective: This study aims To determine the effect of astaxanthin cream on MDA and IL-6 levels in individuals exposed to acute UVBrays.
Methods: An experimental post-test-only control group design with four groups: healthy (K1), negative control (K2), and two treatment groups (K3, K4) exposed to UVBand given 0.05% and 0.1% astaxanthin cream, respectively. UVBirradiation was at 302 nm for 15 minutes, 5 days. MDA levels were measured using the TBARS method, and IL-6 levels were measured using ELISA. Data were analyzed using the Kruskal-Wallis and ANOVA tests.
Results: Average MDA levels were K1 (0.688 nmol/mL), K2 (0.766 nmol/mL), K3 (0.486 nmol/mL), and K4 (0.731 nmol/mL), with significant differences found (p=0.001). Average IL-6 levels were K1 (8.78 ng/L), K2 (6.23 ng/L), K3 (6.49 ng/L), and K4 (7.59 ng/L), with significant differences (p=0.003).
Conclusion: Astaxanthin cream reduces MDA and IL-6 levels following acute UVB exposure. |
| format | Article |
| id | doaj-art-42fea1a6762a45c6a96d2a8bb66becc7 |
| institution | DOAJ |
| issn | 1693-7309 2621-2366 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Universitas Muhammadiyah Purwokerto |
| record_format | Article |
| series | Medisains |
| spelling | doaj-art-42fea1a6762a45c6a96d2a8bb66becc72025-08-20T03:11:03ZengUniversitas Muhammadiyah PurwokertoMedisains1693-73092621-23662025-04-01231667019923In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levelsRudy Ekofitranto0Siti Thomas Zulaikhah1Joko Wahyu Wibowo2Fakultas Kedokteran Universitas Islam Sultan AgungDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Jawa Tengah, IndonesiaDepartment of Biomedical Sciences, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang, Jawa Tengah, IndonesiaBackground: Continuous UVB exposure induces lipid peroxidation and inflammation, with Malondialdehyde (MDA) as an indicator, leading to interleukin-6 (IL-6) secretion. Astaxanthin, a powerful antioxidant, is 50-100 times stronger than vitamin C, but its effects on MDA and IL-6 in UVB exposed skin have not been studied. Objective: This study aims To determine the effect of astaxanthin cream on MDA and IL-6 levels in individuals exposed to acute UVBrays. Methods: An experimental post-test-only control group design with four groups: healthy (K1), negative control (K2), and two treatment groups (K3, K4) exposed to UVBand given 0.05% and 0.1% astaxanthin cream, respectively. UVBirradiation was at 302 nm for 15 minutes, 5 days. MDA levels were measured using the TBARS method, and IL-6 levels were measured using ELISA. Data were analyzed using the Kruskal-Wallis and ANOVA tests. Results: Average MDA levels were K1 (0.688 nmol/mL), K2 (0.766 nmol/mL), K3 (0.486 nmol/mL), and K4 (0.731 nmol/mL), with significant differences found (p=0.001). Average IL-6 levels were K1 (8.78 ng/L), K2 (6.23 ng/L), K3 (6.49 ng/L), and K4 (7.59 ng/L), with significant differences (p=0.003). Conclusion: Astaxanthin cream reduces MDA and IL-6 levels following acute UVB exposure.https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/24667 |
| spellingShingle | Rudy Ekofitranto Siti Thomas Zulaikhah Joko Wahyu Wibowo In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levels Medisains |
| title | In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levels |
| title_full | In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levels |
| title_fullStr | In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levels |
| title_full_unstemmed | In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levels |
| title_short | In vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute UVB by reducing MDA and IL-6 levels |
| title_sort | in vivo study on the effect of astaxanthin cream on preventing inflammation in skin tissue exposed to acute uvb by reducing mda and il 6 levels |
| url | https://jurnalnasional.ump.ac.id/index.php/medisains/article/view/24667 |
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