COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIA
The wide application of cardiac surgery using the aorto-pulmonary bypass technique needs the development of new drugs, capable to minimize the heart damaging during ischemia and reperfusion. But the direct delivery of drugs into the damaged tissues and cells is a big problem. The liposomes as unique...
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| Language: | English |
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Siberian State Medical University (Tomsk)
2013-02-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/36 |
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| author | Ya. G. Toropova R. A. Mukhamadiyarov A. S. Golovkin |
| author_facet | Ya. G. Toropova R. A. Mukhamadiyarov A. S. Golovkin |
| author_sort | Ya. G. Toropova |
| collection | DOAJ |
| description | The wide application of cardiac surgery using the aorto-pulmonary bypass technique needs the development of new drugs, capable to minimize the heart damaging during ischemia and reperfusion. But the direct delivery of drugs into the damaged tissues and cells is a big problem. The liposomes as unique transport system can be used to solve this problem.The aim of the study was to evaluate the influence of "empty" liposomes of various diameter and the liposomes of different composition on the myocardium contractile function which has underwent the ischemia and the subsequent reperfusion. The obtained results allowed us to make the conclusion that liposomes of 50 nanometers in diameter are most effective to cardiac protection versus liposomes of 100 nanometers.Inclusion the emoxipine into the composition of liposomes provide the best results on contractile function of an ischemic myocardium. |
| format | Article |
| id | doaj-art-42f8e8bed59e4df6963e41c79b0864f9 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2013-02-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-42f8e8bed59e4df6963e41c79b0864f92025-08-20T03:38:08ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842013-02-01121556010.20538/1682-0363-2013-1-55-6036COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIAYa. G. Toropova0R. A. Mukhamadiyarov1A. S. Golovkin2Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, KemerovoResearch Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, KemerovoResearch Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, KemerovoThe wide application of cardiac surgery using the aorto-pulmonary bypass technique needs the development of new drugs, capable to minimize the heart damaging during ischemia and reperfusion. But the direct delivery of drugs into the damaged tissues and cells is a big problem. The liposomes as unique transport system can be used to solve this problem.The aim of the study was to evaluate the influence of "empty" liposomes of various diameter and the liposomes of different composition on the myocardium contractile function which has underwent the ischemia and the subsequent reperfusion. The obtained results allowed us to make the conclusion that liposomes of 50 nanometers in diameter are most effective to cardiac protection versus liposomes of 100 nanometers.Inclusion the emoxipine into the composition of liposomes provide the best results on contractile function of an ischemic myocardium.https://bulletin.ssmu.ru/jour/article/view/36liposomesisolated heartischemiareperfusion. |
| spellingShingle | Ya. G. Toropova R. A. Mukhamadiyarov A. S. Golovkin COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIA Бюллетень сибирской медицины liposomes isolated heart ischemia reperfusion. |
| title | COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIA |
| title_full | COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIA |
| title_fullStr | COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIA |
| title_full_unstemmed | COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIA |
| title_short | COMPARATIVE STUDY OF CARDIOPROTECTIVE EFFECT OF VARIOUS DIAMETER AND COMPOSITION LIPOSOMES DURING REPERFUSION OF THE ISOLATED RAT HEARTS AFTER NORMOTHERMIC ISCHEMIA |
| title_sort | comparative study of cardioprotective effect of various diameter and composition liposomes during reperfusion of the isolated rat hearts after normothermic ischemia |
| topic | liposomes isolated heart ischemia reperfusion. |
| url | https://bulletin.ssmu.ru/jour/article/view/36 |
| work_keys_str_mv | AT yagtoropova comparativestudyofcardioprotectiveeffectofvariousdiameterandcompositionliposomesduringreperfusionoftheisolatedratheartsafternormothermicischemia AT ramukhamadiyarov comparativestudyofcardioprotectiveeffectofvariousdiameterandcompositionliposomesduringreperfusionoftheisolatedratheartsafternormothermicischemia AT asgolovkin comparativestudyofcardioprotectiveeffectofvariousdiameterandcompositionliposomesduringreperfusionoftheisolatedratheartsafternormothermicischemia |