Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study
ObjectivePhysical activity (PA) plays an important role in human health. However, the relationship between the PA and dysthyreosis was not clear. This study aimed to explore this question.MethodsWe performed a population-based study on the basis of the participant’s information that was collected fr...
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| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1418766/full |
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| author | Shu-yang Zhang Xue-qing Hu Cheng Xiang Tao Xiang Song-xue Guo Fei-hu Zhi Ping Zhao Jia-yan Zhu Chen-yang Zhang |
| author_facet | Shu-yang Zhang Xue-qing Hu Cheng Xiang Tao Xiang Song-xue Guo Fei-hu Zhi Ping Zhao Jia-yan Zhu Chen-yang Zhang |
| author_sort | Shu-yang Zhang |
| collection | DOAJ |
| description | ObjectivePhysical activity (PA) plays an important role in human health. However, the relationship between the PA and dysthyreosis was not clear. This study aimed to explore this question.MethodsWe performed a population-based study on the basis of the participant’s information that was collected from the National Health and Nutrition Examination Survey (NHANES) database. The association of the thyroid hormone and total PA metabolic equivalent task (MET) were assessed via linear regression analysis with adjusting for different covariates. Moreover, we also used path analysis to explore the causality between PA, thyroid hormone index, and dysthyreosis. The restricted cubic spline analysis was used to explore the non-linear relationship between the thyroid hormone index and the PA total MET.ResultsA total of 2118 participants aged≥20, including 969 females and 1149 males, were collected from NHANES. The linear regression with multivariate adjustment suggested a linear relationship between the PA total MET and Thyroid-Stimulating Hormone Index (TSHI), and Thyroid Feedback Quantile-Based Index (TFQI), respectively. And TFQI and dysthyresis occurrence were significantly correlated (P<0.05). The path analysis showed that the PA total MET affected dysthyreosis occurrence by TFQI. In addition, we found a non-linear relationship between the total PA met and dysthyreosis via restricted cubic spline analysis.ConclusionsPA was significantly correlated with dysthyreosis via thyroid hormone sensitivity. Therefore, it can be considered to prevent the occurrence of dysthyreosis by regulating thyroid hormone sensitivity through PA in daily life. |
| format | Article |
| id | doaj-art-42f8bcde96c14dc2a911908378f2f11f |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-42f8bcde96c14dc2a911908378f2f11f2025-08-20T02:11:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-10-011510.3389/fendo.2024.14187661418766Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based studyShu-yang Zhang0Xue-qing Hu1Cheng Xiang2Tao Xiang3Song-xue Guo4Fei-hu Zhi5Ping Zhao6Jia-yan Zhu7Chen-yang Zhang8Department of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine [Shaoxing Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University], Shaoxing, Zhejiang, ChinaDepartment of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Colorectal Surgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Plastic Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine [Shaoxing Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University], Shaoxing, Zhejiang, ChinaDepartment of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine [Shaoxing Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University], Shaoxing, Zhejiang, ChinaDepartment of General Surgery, Shaoxing Hospital of Traditional Chinese Medicine [Shaoxing Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University], Shaoxing, Zhejiang, ChinaXiangYa School of Medicine, Central South University, Changsha, Hunan, ChinaObjectivePhysical activity (PA) plays an important role in human health. However, the relationship between the PA and dysthyreosis was not clear. This study aimed to explore this question.MethodsWe performed a population-based study on the basis of the participant’s information that was collected from the National Health and Nutrition Examination Survey (NHANES) database. The association of the thyroid hormone and total PA metabolic equivalent task (MET) were assessed via linear regression analysis with adjusting for different covariates. Moreover, we also used path analysis to explore the causality between PA, thyroid hormone index, and dysthyreosis. The restricted cubic spline analysis was used to explore the non-linear relationship between the thyroid hormone index and the PA total MET.ResultsA total of 2118 participants aged≥20, including 969 females and 1149 males, were collected from NHANES. The linear regression with multivariate adjustment suggested a linear relationship between the PA total MET and Thyroid-Stimulating Hormone Index (TSHI), and Thyroid Feedback Quantile-Based Index (TFQI), respectively. And TFQI and dysthyresis occurrence were significantly correlated (P<0.05). The path analysis showed that the PA total MET affected dysthyreosis occurrence by TFQI. In addition, we found a non-linear relationship between the total PA met and dysthyreosis via restricted cubic spline analysis.ConclusionsPA was significantly correlated with dysthyreosis via thyroid hormone sensitivity. Therefore, it can be considered to prevent the occurrence of dysthyreosis by regulating thyroid hormone sensitivity through PA in daily life.https://www.frontiersin.org/articles/10.3389/fendo.2024.1418766/fullphysical activitythyroid feedback quantile-based indexsensitivitydysthyreosismetabolic equivalent taskhypothalamic pituitary thyroid axis |
| spellingShingle | Shu-yang Zhang Xue-qing Hu Cheng Xiang Tao Xiang Song-xue Guo Fei-hu Zhi Ping Zhao Jia-yan Zhu Chen-yang Zhang Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study Frontiers in Endocrinology physical activity thyroid feedback quantile-based index sensitivity dysthyreosis metabolic equivalent task hypothalamic pituitary thyroid axis |
| title | Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study |
| title_full | Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study |
| title_fullStr | Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study |
| title_full_unstemmed | Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study |
| title_short | Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study |
| title_sort | physical activity affects dysthyreosis by thyroid hormones sensitivity a population based study |
| topic | physical activity thyroid feedback quantile-based index sensitivity dysthyreosis metabolic equivalent task hypothalamic pituitary thyroid axis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1418766/full |
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