A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii.

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii.

CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests. A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles. One approach to mitigate the development of resistance involves targetin...

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Bibliographic Details
Main Authors: Suhan Ma, Xuyang Ni, Shimin Chen, Xiaomu Qiao, Xuejiao Xu, Weizhe Chen, Jackson Champer, Jia Huang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-04-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011226&type=printable
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