Methotrexate and mucositis: A merry-go-round for oncologists
High-dose methotrexate is the backbone of various regimens for treating lymphoid malignancies. Mucositis is a well-known, dose-related side effect of methotrexate. Prophylactic measures such as folinic acid rescue are useful but do not prevent mucositis in all the cases. Once severe mucositis (WHO G...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=1;spage=150;epage=152;aulast=Mishra |
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| author | Kundan Mishra Aditya Jandial Anil Kumar Deepesh Lad Gaurav Prakash Alka Khadwal Pankaj Malhotra |
| author_facet | Kundan Mishra Aditya Jandial Anil Kumar Deepesh Lad Gaurav Prakash Alka Khadwal Pankaj Malhotra |
| author_sort | Kundan Mishra |
| collection | DOAJ |
| description | High-dose methotrexate is the backbone of various regimens for treating lymphoid malignancies. Mucositis is a well-known, dose-related side effect of methotrexate. Prophylactic measures such as folinic acid rescue are useful but do not prevent mucositis in all the cases. Once severe mucositis (WHO Grade IV) sets in, mortality is very high. The index case highlights the natural course of methotrexate-induced mucositis and the need for swift and preemptive intervention. |
| format | Article |
| id | doaj-art-42f1f22970804b71a15c7bb0e856b435 |
| institution | DOAJ |
| issn | 0971-5851 0975-2129 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-42f1f22970804b71a15c7bb0e856b4352025-08-20T03:06:37ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-21292019-01-0140115015210.4103/ijmpo.ijmpo_113_18Methotrexate and mucositis: A merry-go-round for oncologistsKundan MishraAditya JandialAnil KumarDeepesh LadGaurav PrakashAlka KhadwalPankaj MalhotraHigh-dose methotrexate is the backbone of various regimens for treating lymphoid malignancies. Mucositis is a well-known, dose-related side effect of methotrexate. Prophylactic measures such as folinic acid rescue are useful but do not prevent mucositis in all the cases. Once severe mucositis (WHO Grade IV) sets in, mortality is very high. The index case highlights the natural course of methotrexate-induced mucositis and the need for swift and preemptive intervention.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=1;spage=150;epage=152;aulast=MishraLymphoid malignancymethotrexatemucositis |
| spellingShingle | Kundan Mishra Aditya Jandial Anil Kumar Deepesh Lad Gaurav Prakash Alka Khadwal Pankaj Malhotra Methotrexate and mucositis: A merry-go-round for oncologists Indian Journal of Medical and Paediatric Oncology Lymphoid malignancy methotrexate mucositis |
| title | Methotrexate and mucositis: A merry-go-round for oncologists |
| title_full | Methotrexate and mucositis: A merry-go-round for oncologists |
| title_fullStr | Methotrexate and mucositis: A merry-go-round for oncologists |
| title_full_unstemmed | Methotrexate and mucositis: A merry-go-round for oncologists |
| title_short | Methotrexate and mucositis: A merry-go-round for oncologists |
| title_sort | methotrexate and mucositis a merry go round for oncologists |
| topic | Lymphoid malignancy methotrexate mucositis |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2019;volume=40;issue=1;spage=150;epage=152;aulast=Mishra |
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