Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map
ObjectivesThis protocol outlines the development of a systematic evidence map (SEM) on genetic and epigenetic alterations associated with human prenatal tobacco exposure. The SEM will identify and synthetize epidemiological data on periconceptional and prenatal tobacco exposure associated with genet...
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Frontiers Media S.A.
2025-07-01
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| Series: | Public Health Reviews |
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| Online Access: | https://www.ssph-journal.org/articles/10.3389/phrs.2025.1606742/full |
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| author | Ana Teresa Reis Ana Teresa Reis Ana Teresa Reis Joana Madureira Joana Madureira Joana Madureira João Paulo Teixeira João Paulo Teixeira João Paulo Teixeira Carla Costa Carla Costa Carla Costa |
| author_facet | Ana Teresa Reis Ana Teresa Reis Ana Teresa Reis Joana Madureira Joana Madureira Joana Madureira João Paulo Teixeira João Paulo Teixeira João Paulo Teixeira Carla Costa Carla Costa Carla Costa |
| author_sort | Ana Teresa Reis |
| collection | DOAJ |
| description | ObjectivesThis protocol outlines the development of a systematic evidence map (SEM) on genetic and epigenetic alterations associated with human prenatal tobacco exposure. The SEM will identify and synthetize epidemiological data on periconceptional and prenatal tobacco exposure associated with genetic (e.g., DNA damage) and epigenetic (e.g., DNA methylation) outcomes. Furthermore, it will describe the available evidence, highlight knowledge clusters, and identify gaps for future research.MethodsBibliographic databases and grey literature sources will be searched, complemented by reference mining. Predefined inclusion and exclusion criteria will guide study inclusion. Data extraction will include population, exposure, comparator, outcome, funding, study design, confounding factors, and statistical methods. Summarization will include a narrative review, graphical visualization, and an interactive, queryable and open-access table.ResultsA pilot study assessed the protocol’s feasibility, testing key components, including screening, data extraction, and eligibility criteria. Findings confirmed that the methodology is workable and reliable.ConclusionThis protocol supports a rigorous, reproducible, transparent SEM, aligned with international standards. The comprehensive mapping will support research prioritization and inform public health policies targeting maternal and child health. |
| format | Article |
| id | doaj-art-42ecc9ef583649bfb0978db7e13f082c |
| institution | Kabale University |
| issn | 2107-6952 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Public Health Reviews |
| spelling | doaj-art-42ecc9ef583649bfb0978db7e13f082c2025-08-20T04:02:22ZengFrontiers Media S.A.Public Health Reviews2107-69522025-07-014610.3389/phrs.2025.16067421606742Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence MapAna Teresa Reis0Ana Teresa Reis1Ana Teresa Reis2Joana Madureira3Joana Madureira4Joana Madureira5João Paulo Teixeira6João Paulo Teixeira7João Paulo Teixeira8Carla Costa9Carla Costa10Carla Costa11Environmental Health Department, National Institute of Health Doutor Ricardo Jorge, Porto, PortugalEPIUnit – Instituto de Saúde Pública, Universidade do Porto, Porto, PortugalLaboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, PortugalEnvironmental Health Department, National Institute of Health Doutor Ricardo Jorge, Porto, PortugalEPIUnit – Instituto de Saúde Pública, Universidade do Porto, Porto, PortugalLaboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, PortugalEnvironmental Health Department, National Institute of Health Doutor Ricardo Jorge, Porto, PortugalEPIUnit – Instituto de Saúde Pública, Universidade do Porto, Porto, PortugalLaboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, PortugalEnvironmental Health Department, National Institute of Health Doutor Ricardo Jorge, Porto, PortugalEPIUnit – Instituto de Saúde Pública, Universidade do Porto, Porto, PortugalLaboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Porto, PortugalObjectivesThis protocol outlines the development of a systematic evidence map (SEM) on genetic and epigenetic alterations associated with human prenatal tobacco exposure. The SEM will identify and synthetize epidemiological data on periconceptional and prenatal tobacco exposure associated with genetic (e.g., DNA damage) and epigenetic (e.g., DNA methylation) outcomes. Furthermore, it will describe the available evidence, highlight knowledge clusters, and identify gaps for future research.MethodsBibliographic databases and grey literature sources will be searched, complemented by reference mining. Predefined inclusion and exclusion criteria will guide study inclusion. Data extraction will include population, exposure, comparator, outcome, funding, study design, confounding factors, and statistical methods. Summarization will include a narrative review, graphical visualization, and an interactive, queryable and open-access table.ResultsA pilot study assessed the protocol’s feasibility, testing key components, including screening, data extraction, and eligibility criteria. Findings confirmed that the methodology is workable and reliable.ConclusionThis protocol supports a rigorous, reproducible, transparent SEM, aligned with international standards. The comprehensive mapping will support research prioritization and inform public health policies targeting maternal and child health.https://www.ssph-journal.org/articles/10.3389/phrs.2025.1606742/fullhuman prenatal exposuregenotoxicityepigeneticstobaccoenvironmental tobacco smoke |
| spellingShingle | Ana Teresa Reis Ana Teresa Reis Ana Teresa Reis Joana Madureira Joana Madureira Joana Madureira João Paulo Teixeira João Paulo Teixeira João Paulo Teixeira Carla Costa Carla Costa Carla Costa Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map Public Health Reviews human prenatal exposure genotoxicity epigenetics tobacco environmental tobacco smoke |
| title | Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map |
| title_full | Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map |
| title_fullStr | Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map |
| title_full_unstemmed | Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map |
| title_short | Genetic and Epigenetic Alterations Associated With Human Prenatal Tobacco and Environmental Tobacco Smoke Exposure: Protocol for a Systematic Evidence Map |
| title_sort | genetic and epigenetic alterations associated with human prenatal tobacco and environmental tobacco smoke exposure protocol for a systematic evidence map |
| topic | human prenatal exposure genotoxicity epigenetics tobacco environmental tobacco smoke |
| url | https://www.ssph-journal.org/articles/10.3389/phrs.2025.1606742/full |
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