Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters
ABSTRACT Objective To simulate thrombotic occlusion of catheters and develop a model for thrombotic occlusion in peripherally inserted central catheters (PICC), providing a framework for research on catheter occlusion and post‐occlusion recanalization. Methods Following preparatory steps prior to mo...
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| Language: | English |
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Wiley
2025-05-01
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| Series: | Annals of Noninvasive Electrocardiology |
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| Online Access: | https://doi.org/10.1111/anec.70090 |
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| author | Feng‐Xian Li Qiao‐hong Guo |
| author_facet | Feng‐Xian Li Qiao‐hong Guo |
| author_sort | Feng‐Xian Li |
| collection | DOAJ |
| description | ABSTRACT Objective To simulate thrombotic occlusion of catheters and develop a model for thrombotic occlusion in peripherally inserted central catheters (PICC), providing a framework for research on catheter occlusion and post‐occlusion recanalization. Methods Following preparatory steps prior to modeling, sterile anticoagulant bovine blood was drawn and injected into the PICC. Subsequently, the catheter tip was clamped and left to stand for 72 h. Results A total of 140 catheter models were produced, all of which exhibited thrombosis, resulting in a 100% success rate for intra‐catheter thrombus production. Of these, 118 models experienced no blood reflux when the syringe plunger was withdrawn and triggered an infusion pump alarm, achieving a catheter occlusion modeling success rate of 84.29%. There were 127 cases where syringe plunger withdrawal resulted in no blood reflux within the thrombotic catheter occlusion models, yielding an incidence rate of 90.71%, while 13 cases revealed blood reflux mixed with fine thrombosis, with an incidence rate of 9.29%. Additionally, 126 models triggered infusion pump alarms, with an incidence rate of 90%, while 14 models did not trigger alarms due to thrombus overflow at the catheter tip, with an incidence rate of 10%. The infusion pump alarm method and the syringe withdrawal method demonstrated a significant correlation in diagnosing thrombotic catheter occlusion. Conclusion The method for modeling thrombotic catheter occlusion used in this study is reliable, producing a model that accurately simulates the fundamental characteristics of thrombotic catheter occlusion. This model has the potential for application in clinical practice. |
| format | Article |
| id | doaj-art-42eb77c10c6e4ad9803bf1495c09ae29 |
| institution | OA Journals |
| issn | 1082-720X 1542-474X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Noninvasive Electrocardiology |
| spelling | doaj-art-42eb77c10c6e4ad9803bf1495c09ae292025-08-20T02:29:04ZengWileyAnnals of Noninvasive Electrocardiology1082-720X1542-474X2025-05-01303n/an/a10.1111/anec.70090Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central CathetersFeng‐Xian Li0Qiao‐hong Guo1College of Nursing Capital Medical University Beijing ChinaCollege of Nursing Capital Medical University Beijing ChinaABSTRACT Objective To simulate thrombotic occlusion of catheters and develop a model for thrombotic occlusion in peripherally inserted central catheters (PICC), providing a framework for research on catheter occlusion and post‐occlusion recanalization. Methods Following preparatory steps prior to modeling, sterile anticoagulant bovine blood was drawn and injected into the PICC. Subsequently, the catheter tip was clamped and left to stand for 72 h. Results A total of 140 catheter models were produced, all of which exhibited thrombosis, resulting in a 100% success rate for intra‐catheter thrombus production. Of these, 118 models experienced no blood reflux when the syringe plunger was withdrawn and triggered an infusion pump alarm, achieving a catheter occlusion modeling success rate of 84.29%. There were 127 cases where syringe plunger withdrawal resulted in no blood reflux within the thrombotic catheter occlusion models, yielding an incidence rate of 90.71%, while 13 cases revealed blood reflux mixed with fine thrombosis, with an incidence rate of 9.29%. Additionally, 126 models triggered infusion pump alarms, with an incidence rate of 90%, while 14 models did not trigger alarms due to thrombus overflow at the catheter tip, with an incidence rate of 10%. The infusion pump alarm method and the syringe withdrawal method demonstrated a significant correlation in diagnosing thrombotic catheter occlusion. Conclusion The method for modeling thrombotic catheter occlusion used in this study is reliable, producing a model that accurately simulates the fundamental characteristics of thrombotic catheter occlusion. This model has the potential for application in clinical practice.https://doi.org/10.1111/anec.70090modelperipherally inserted central catheterPICC occlusion |
| spellingShingle | Feng‐Xian Li Qiao‐hong Guo Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters Annals of Noninvasive Electrocardiology model peripherally inserted central catheter PICC occlusion |
| title | Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters |
| title_full | Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters |
| title_fullStr | Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters |
| title_full_unstemmed | Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters |
| title_short | Simulation and Modeling Thrombotic Occlusion in Peripherally Inserted Central Catheters |
| title_sort | simulation and modeling thrombotic occlusion in peripherally inserted central catheters |
| topic | model peripherally inserted central catheter PICC occlusion |
| url | https://doi.org/10.1111/anec.70090 |
| work_keys_str_mv | AT fengxianli simulationandmodelingthromboticocclusioninperipherallyinsertedcentralcatheters AT qiaohongguo simulationandmodelingthromboticocclusioninperipherallyinsertedcentralcatheters |