Commentary: The ubiquitin-proteasome system in the tumor immune microenvironment: a key force in combination therapy

Commentary: The ubiquitin-proteasome system in the tumor immune microenvironment: a key force in combination therapy

Saved in:

Bibliographic Details
Main Authors:	Lu Zhang, Liping Jia, Linhan Wang, Wenxiu Yuan, Xin Shi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Immunology
Subjects:	ubiquitin-proteasome system tumor immune microenvironment proteolysis targeting chimeras (PROTACs) Foxp 3 ubiquitination cancer therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1522427/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

PROTAC-Based Antivirals for Respiratory Viruses: A Novel Approach for Targeted Therapy and Vaccine Development
by: Amith Anugu, et al.
Published: (2025-07-01)

ROLE OF UBIQUITIN PROTEASOME SYSTEM IN GASTRIC CANCER PATHOGENESIS
by: E. V. Ivanova, et al.
Published: (2016-02-01)

Unraveling chain specific ubiquitination in cells using tandem ubiquitin binding entities
by: Muhammad Shahzad Ali, et al.
Published: (2025-07-01)

The Ac/N-Degron Domain of MARCHF6 E3 Ubiquitin Ligase and Its Role in Regulating Ferroptosis
by: Hope Omoniyi, et al.
Published: (2025-06-01)

Role of the ubiquitin-proteasome system in the progression of oral squamous cell carcinoma
by: D. E. Mikhalev, et al.
Published: (2021-07-01)

Elevated ubiquitin phosphorylation by PINK1 contributes to proteasomal impairment and promotes neurodegeneration
by: Cong Chen, et al.
Published: (2025-07-01)

Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome
by: R. Roshini Beenukumar, et al.
Published: (2015-05-01)

Renal Implications of Dysregulated Protein Homeostasis: Insights into Ubiquitin–Proteasome and Autophagy Systems
by: Charlotte Delrue, et al.
Published: (2025-02-01)

Proteasomes and Ubiquitin C-Terminal Hydrolase L1 as Biomarkers of Tissue Damage and Inflammatory Response to Different Types of Injury—A Short Review
by: Marzena Tylicka, et al.
Published: (2025-03-01)

Dysregulation of ubiquitination modification in renal cell carcinoma
by: Hongjie You, et al.
Published: (2024-12-01)

Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression
by: Yulan Huang, et al.
Published: (2025-03-01)

Combating Malaria: Targeting the Ubiquitin-Proteasome System to Conquer Drug Resistance
by: Bazgha Sanaullah, et al.
Published: (2025-04-01)

TrypPROTACs Unlocking New Therapeutic Strategies for Chagas Disease
by: Ana Luísa Rodriguez Gini, et al.
Published: (2025-06-01)

PROTAC<sup>®</sup> technology and potential for its application in infection control
by: M. A. Zakharova, et al.
Published: (2024-07-01)

The Role of the Ubiquitin System in Eye Diseases
by: Sandra Carolina Durán-Cristiano, et al.
Published: (2025-03-01)

Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors Rpn10 and Rpn13 in Germ Cell Formation and Fertility
by: Wan-Yu Yue, et al.
Published: (2025-05-01)

Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities
by: Aiman B. Awan, et al.
Published: (2025-01-01)

Regulation of retinoic acid inducible gene I signal transduction by bluetongue virus through the ubiquitin-proteasome system
by: Danfeng LU, et al.
Published: (2025-09-01)

Research Progress of PROTAC-Degraded CDKs in the Treatment of Breast Cancer
by: Zhao K, et al.
Published: (2025-06-01)

Proteasome dynamics in response to metabolic changes
by: Cordula Enenkel, et al.
Published: (2025-03-01)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
by: Dongha Kim, et al.
Published: (2025-08-01)

F-box proteins at the crossroads of ubiquitination and tumor immunity: regulatory networks and immunotherapy strategies
by: Mingzheng Dai, et al.
Published: (2025-06-01)

Mechanisms of Cbl-Mediated Ubiquitination of Proteins in T and Natural Killer Cells and Effects on Immune Cell Functions
by: Pulak Ranjan Nath, et al.
Published: (2024-12-01)

Design, synthesis, and anti-inflammatory potential of PROTAC drug molecules based on fondaparinux sodium
by: Ruoxuan Wu, et al.
Published: (2025-07-01)

Advancing Design Strategy of PROTACs for Cancer Therapy
by: Hang Luo, et al.
Published: (2025-07-01)

Preparation and Characterization of Ternary Complexes to Improve the Solubility and Dissolution Performance of a Proteolysis-Targeting Chimera Drug
by: Heng Zhang, et al.
Published: (2025-05-01)

Proteome Profiling of <i>S. cerevisiae</i> Strains Lacking the Ubiquitin-Conjugating Enzymes Ubc4 and Ubc5 During Exponential Growth and After Heat Shock Treatment
by: Valentina Rossio, et al.
Published: (2024-11-01)

Emerging Role of Ubiquitin Proteasome System and Autophagy in Pediatric Demyelinating Leukodystrophies and Therapeutic Opportunity
by: Dar-Shong Lin, et al.
Published: (2024-11-01)

Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy
by: Sweta Jha, et al.
Published: (2025-02-01)

Emerging roles of HECT‐type E3 ubiquitin ligases in autophagy regulation
by: Gerry Melino, et al.
Published: (2019-10-01)

The ubiquitin-proteasome system in circadian regulation
by: Kara M. Costanzo, et al.
Published: (2025-08-01)

A new era in cancer therapy: targeting the Proteasome-Bcl-2 axis
by: Sourabh Soni, et al.
Published: (2025-08-01)

Exploration of the ubiquitination-related molecular classification and signature to predict the survival and immune microenvironment in colon cancer
by: Ji-Zhong Xu, et al.
Published: (2024-08-01)

The Role of Ubiquitin-Proteasome System (UPS) in Asthma Pathology
by: Deng S, et al.
Published: (2025-03-01)

Proteasome inhibitors: situation and prospects (literature review and own data)
by: A. A. Rukavitsyn, et al.
Published: (2016-10-01)

A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases
by: Adam Hage, et al.
Published: (2025-04-01)

Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation
by: Huijing Chen, et al.
Published: (2019-01-01)

Role and therapeutic potential of the NEDD4 family in breast cancer
by: Xiaoxiao Zhang, et al.
Published: (2025-06-01)

Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
by: Huiyuan Yang, et al.
Published: (2025-02-01)

A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system
by: Sjoerd J L van Wijk, et al.
Published: (2009-08-01)