Intermittent Atrioventricular Block following Fingolimod Initiation
A 47-year-old female patient with multiple sclerosis (MS) developed symptomatic intermittent 2nd degree atrioventricular block (AVB) of five-hour duration, five hours after the first two doses of fingolimod, that resolved completely. Frequency domain analysis of heart rate variability (HRV) revealed...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/191305 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560939705040896 |
|---|---|
| author | E. Gialafos S. Gerakoulis A. Grigoriou V. Haina C. Kilidireas E. Stamboulis E. Andreadou |
| author_facet | E. Gialafos S. Gerakoulis A. Grigoriou V. Haina C. Kilidireas E. Stamboulis E. Andreadou |
| author_sort | E. Gialafos |
| collection | DOAJ |
| description | A 47-year-old female patient with multiple sclerosis (MS) developed symptomatic intermittent 2nd degree atrioventricular block (AVB) of five-hour duration, five hours after the first two doses of fingolimod, that resolved completely. Frequency domain analysis of heart rate variability (HRV) revealed increased parasympathetic activity and decreased sympathetic tone, while modified Ewing tests were suggestive of impaired cardiac sympathetic function. We hypothesize that expression of this particular arrhythmia might be related to autonomic nervous system (ANS) dysfunction due to demyelinating lesions in the upper thoracic spinal cord, possibly augmented by the parasympathetic effect of the drug. |
| format | Article |
| id | doaj-art-42d96bd340c34f3a990c348ad048063a |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-42d96bd340c34f3a990c348ad048063a2025-02-03T01:26:22ZengWileyCase Reports in Neurological Medicine2090-66682090-66762014-01-01201410.1155/2014/191305191305Intermittent Atrioventricular Block following Fingolimod InitiationE. Gialafos0S. Gerakoulis1A. Grigoriou2V. Haina3C. Kilidireas4E. Stamboulis5E. Andreadou6Department of Neurology, Athens National and Kapodistrian University, “Aeginition” Hospital, 11528 Athens, GreeceDepartment of Neurology, Athens National and Kapodistrian University, “Aeginition” Hospital, 11528 Athens, GreeceDepartment of Neurology, Athens National and Kapodistrian University, “Aeginition” Hospital, 11528 Athens, GreeceDepartment of Neurology, Athens National and Kapodistrian University, “Aeginition” Hospital, 11528 Athens, GreeceDepartment of Neurology, Athens National and Kapodistrian University, “Aeginition” Hospital, 11528 Athens, GreeceDepartment of Neurology, Athens National and Kapodistrian University, “Aeginition” Hospital, 11528 Athens, GreeceDepartment of Neurology, Athens National and Kapodistrian University, “Aeginition” Hospital, 11528 Athens, GreeceA 47-year-old female patient with multiple sclerosis (MS) developed symptomatic intermittent 2nd degree atrioventricular block (AVB) of five-hour duration, five hours after the first two doses of fingolimod, that resolved completely. Frequency domain analysis of heart rate variability (HRV) revealed increased parasympathetic activity and decreased sympathetic tone, while modified Ewing tests were suggestive of impaired cardiac sympathetic function. We hypothesize that expression of this particular arrhythmia might be related to autonomic nervous system (ANS) dysfunction due to demyelinating lesions in the upper thoracic spinal cord, possibly augmented by the parasympathetic effect of the drug.http://dx.doi.org/10.1155/2014/191305 |
| spellingShingle | E. Gialafos S. Gerakoulis A. Grigoriou V. Haina C. Kilidireas E. Stamboulis E. Andreadou Intermittent Atrioventricular Block following Fingolimod Initiation Case Reports in Neurological Medicine |
| title | Intermittent Atrioventricular Block following Fingolimod Initiation |
| title_full | Intermittent Atrioventricular Block following Fingolimod Initiation |
| title_fullStr | Intermittent Atrioventricular Block following Fingolimod Initiation |
| title_full_unstemmed | Intermittent Atrioventricular Block following Fingolimod Initiation |
| title_short | Intermittent Atrioventricular Block following Fingolimod Initiation |
| title_sort | intermittent atrioventricular block following fingolimod initiation |
| url | http://dx.doi.org/10.1155/2014/191305 |
| work_keys_str_mv | AT egialafos intermittentatrioventricularblockfollowingfingolimodinitiation AT sgerakoulis intermittentatrioventricularblockfollowingfingolimodinitiation AT agrigoriou intermittentatrioventricularblockfollowingfingolimodinitiation AT vhaina intermittentatrioventricularblockfollowingfingolimodinitiation AT ckilidireas intermittentatrioventricularblockfollowingfingolimodinitiation AT estamboulis intermittentatrioventricularblockfollowingfingolimodinitiation AT eandreadou intermittentatrioventricularblockfollowingfingolimodinitiation |