Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway

Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway

Abstract Atherosclerosis, a chronic inflammatory condition characterized by plaque formation, often leads to instability, particularly under Type 2 diabetes mellitus (T2DM) conditions, which exacerbate cardiovascular risks. However, the molecular mechanisms underlying this process remain incompletel...

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Main Authors: Zhongwei Liu, Jing Liu, Xiqiang Wang, Yong Zhang, Yanpeng Ma, Gongchang Guan, Ya Yuwen, Ni He, Hanxiu Liu, Xingfeng Yu, Sen Ma, Junkui Wang, Jin Zhang, Ling Zhu, Yulian Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cardiovascular Diabetology
Subjects:
Advanced glycation end products
Nε-carboxyethyl-lysin
Atherosclerotic plaque vulnerability
Macrophage autophagy
Type 2 diabetes mellitus
Online Access:https://doi.org/10.1186/s12933-025-02586-y
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