The role of immune mechanisms in hypertension and advances in immunomodulatory research
Hypertension is one of the major risk factors for cardiovascular diseases and end-organ damage worldwide. Traditionally, it has been linked to factors such as genetics, diet, and lifestyle. However, increasing research indicates that the immune system also plays an important role in the initiation a...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/10641963.2025.2535328 |
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| author | XiaoLi Chen Ling Sun Ke Xuan Aifen Zong |
| author_facet | XiaoLi Chen Ling Sun Ke Xuan Aifen Zong |
| author_sort | XiaoLi Chen |
| collection | DOAJ |
| description | Hypertension is one of the major risk factors for cardiovascular diseases and end-organ damage worldwide. Traditionally, it has been linked to factors such as genetics, diet, and lifestyle. However, increasing research indicates that the immune system also plays an important role in the initiation and progression of hypertension. In the initiation phase, pro-hypertensive stimuli including chronic sympathetic nervous system (SNS), high salt intake and imbalanced gut microbes all influence the function of immune cells, contributing to the development of elevated blood pressure. As hypertension progresses, many immune cells, such as macrophages, dendritic cells, NK cells, B and T lymphocytes, accumulate in organs such as the heart, blood vessels, and kidneys. These cells release effector cytokines and reactive oxygen species, exacerbating tissue damage and organ dysfunction. Meanwhile, numerous studies suggest that intervening in immune inflammatory processes has the potential to regulate blood pressure and prevent damage to vital organs. This review aims to explore the role of immune regulation in various stages of hypertension and the progress of research on immune interventions for hypertension treatment, with the aim of providing new perspectives and approaches for future research and treatment of hypertension. |
| format | Article |
| id | doaj-art-42d28b2c5bca4fe5bb71b49ac8396e6b |
| institution | Kabale University |
| issn | 1064-1963 1525-6006 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj-art-42d28b2c5bca4fe5bb71b49ac8396e6b2025-08-22T13:00:57ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062025-12-0147110.1080/10641963.2025.2535328The role of immune mechanisms in hypertension and advances in immunomodulatory researchXiaoLi Chen0Ling Sun1Ke Xuan2Aifen Zong3Department of Pathology, People’s Hospital of Huantai County, Zibo, Shandong, ChinaDepartment of Electrocardiography, People’s Hospital of Huantai County, Zibo, Shandong, ChinaDepartment of Pathology, People’s Hospital of Huantai County, Zibo, Shandong, ChinaDepartment of Cardiology, People’s Hospital of Huantai County, Zibo, Shandong, ChinaHypertension is one of the major risk factors for cardiovascular diseases and end-organ damage worldwide. Traditionally, it has been linked to factors such as genetics, diet, and lifestyle. However, increasing research indicates that the immune system also plays an important role in the initiation and progression of hypertension. In the initiation phase, pro-hypertensive stimuli including chronic sympathetic nervous system (SNS), high salt intake and imbalanced gut microbes all influence the function of immune cells, contributing to the development of elevated blood pressure. As hypertension progresses, many immune cells, such as macrophages, dendritic cells, NK cells, B and T lymphocytes, accumulate in organs such as the heart, blood vessels, and kidneys. These cells release effector cytokines and reactive oxygen species, exacerbating tissue damage and organ dysfunction. Meanwhile, numerous studies suggest that intervening in immune inflammatory processes has the potential to regulate blood pressure and prevent damage to vital organs. This review aims to explore the role of immune regulation in various stages of hypertension and the progress of research on immune interventions for hypertension treatment, with the aim of providing new perspectives and approaches for future research and treatment of hypertension.https://www.tandfonline.com/doi/10.1080/10641963.2025.2535328Hypertensionimmune systemimmune activationorgan damageimmunotherapy |
| spellingShingle | XiaoLi Chen Ling Sun Ke Xuan Aifen Zong The role of immune mechanisms in hypertension and advances in immunomodulatory research Clinical and Experimental Hypertension Hypertension immune system immune activation organ damage immunotherapy |
| title | The role of immune mechanisms in hypertension and advances in immunomodulatory research |
| title_full | The role of immune mechanisms in hypertension and advances in immunomodulatory research |
| title_fullStr | The role of immune mechanisms in hypertension and advances in immunomodulatory research |
| title_full_unstemmed | The role of immune mechanisms in hypertension and advances in immunomodulatory research |
| title_short | The role of immune mechanisms in hypertension and advances in immunomodulatory research |
| title_sort | role of immune mechanisms in hypertension and advances in immunomodulatory research |
| topic | Hypertension immune system immune activation organ damage immunotherapy |
| url | https://www.tandfonline.com/doi/10.1080/10641963.2025.2535328 |
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