The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis
Background. Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence. Aim. To map the incidence and prevalence of PBC in European countries from 2000 through 2020. Methods. Following PRISMA recommendations, we searched...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/9151525 |
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| author | Jakub Gazda Sylvia Drazilova Martin Janicko Peter Jarcuska |
| author_facet | Jakub Gazda Sylvia Drazilova Martin Janicko Peter Jarcuska |
| author_sort | Jakub Gazda |
| collection | DOAJ |
| description | Background. Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence. Aim. To map the incidence and prevalence of PBC in European countries from 2000 through 2020. Methods. Following PRISMA recommendations, we searched the Medline and Scopus databases for studies with information on either the incidence or prevalence of PBC. After data extraction, we used a random-effects model to estimate both the pooled annual incidence rate and pooled point-prevalence rate and performed subgroup analyses to identify components contributing to between-study heterogeneity. Results. We performed a qualitative and quantitative analysis of 18 studies. The pooled point-prevalence rate was 22.27 cases per 100,000 inhabitants (95% CI: 17.98–27.01), and the pooled annual incidence rate was 1.87 new cases per 100,000 inhabitants (95% CI: 1.46–2.34). In the subgroup analyses, we proved that a small part of the between-study heterogeneity is significantly associated with a history of being part of the Eastern Bloc. |
| format | Article |
| id | doaj-art-42cd3ce3c6324e15b82d162977e6e69b |
| institution | DOAJ |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-42cd3ce3c6324e15b82d162977e6e69b2025-08-20T02:39:18ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/91515259151525The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-AnalysisJakub Gazda0Sylvia Drazilova1Martin Janicko2Peter Jarcuska32nd Department of Internal Medicine, PJ Safarik University in Kosice and L. Pasteur University Hospital, Trieda SNP 1, Kosice 040 11, Slovakia2nd Department of Internal Medicine, PJ Safarik University in Kosice and L. Pasteur University Hospital, Trieda SNP 1, Kosice 040 11, Slovakia2nd Department of Internal Medicine, PJ Safarik University in Kosice and L. Pasteur University Hospital, Trieda SNP 1, Kosice 040 11, Slovakia2nd Department of Internal Medicine, PJ Safarik University in Kosice and L. Pasteur University Hospital, Trieda SNP 1, Kosice 040 11, SlovakiaBackground. Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease with wide ranges of reported incidence and prevalence. Aim. To map the incidence and prevalence of PBC in European countries from 2000 through 2020. Methods. Following PRISMA recommendations, we searched the Medline and Scopus databases for studies with information on either the incidence or prevalence of PBC. After data extraction, we used a random-effects model to estimate both the pooled annual incidence rate and pooled point-prevalence rate and performed subgroup analyses to identify components contributing to between-study heterogeneity. Results. We performed a qualitative and quantitative analysis of 18 studies. The pooled point-prevalence rate was 22.27 cases per 100,000 inhabitants (95% CI: 17.98–27.01), and the pooled annual incidence rate was 1.87 new cases per 100,000 inhabitants (95% CI: 1.46–2.34). In the subgroup analyses, we proved that a small part of the between-study heterogeneity is significantly associated with a history of being part of the Eastern Bloc.http://dx.doi.org/10.1155/2021/9151525 |
| spellingShingle | Jakub Gazda Sylvia Drazilova Martin Janicko Peter Jarcuska The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis Canadian Journal of Gastroenterology and Hepatology |
| title | The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis |
| title_full | The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis |
| title_fullStr | The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis |
| title_short | The Epidemiology of Primary Biliary Cholangitis in European Countries: A Systematic Review and Meta-Analysis |
| title_sort | epidemiology of primary biliary cholangitis in european countries a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2021/9151525 |
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