Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation
Post-traumatic arthritis (PTA) develops after an acute direct trauma to the joints. PTA causes about 12% of all osteoarthritis cases, and a history of physical trauma may also be found in patients with chronic inflammatory arthritis. Symptoms include swelling, synovial effusion, pain and sometimes i...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2016-09-01
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| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/2/2/e000279.full |
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| author | Roberta Ramonda Leonardo Punzi Anna Scanu Francesca Oliviero Roberto Luisetto Paola Galozzi Marta Favero |
| author_facet | Roberta Ramonda Leonardo Punzi Anna Scanu Francesca Oliviero Roberto Luisetto Paola Galozzi Marta Favero |
| author_sort | Roberta Ramonda |
| collection | DOAJ |
| description | Post-traumatic arthritis (PTA) develops after an acute direct trauma to the joints. PTA causes about 12% of all osteoarthritis cases, and a history of physical trauma may also be found in patients with chronic inflammatory arthritis. Symptoms include swelling, synovial effusion, pain and sometimes intra-articular bleeding. Usually, PTA recoveries spontaneously, but the persistence of symptoms after 6 months may be considered pathological and so-called chronic PTA. A variety of molecular, mechanobiological and cellular events involved in the pathogenesis and the progression of PTA have been identified. The activation of inflammatory mechanisms during the PTA acute phase appears to play a critical role in the chronic disease onset. Human studies and experimental models have revealed that a series of inflammatory mediators are released in synovial fluid immediately after the joint trauma. These molecules have been proposed as markers of disease and as a potential target for the development of specific and preventative interventions. Currently, chronic PTA cannot be prevented, although a large number of agents have been tested in preclinical studies. Given the relevance of inflammatory reaction, anticytokines therapy, in particular the inhibition of interleukin 1 (IL-1), seems to be the most promising strategy. At the present time, intra-articular injection of IL-1 receptor antagonist is the only anticytokine approach that has been used in a human study of PTA. Despite the fact that knowledge in this area has increased in the past years, the identification of more specific disease markers and new therapeutic opportunities are needed. |
| format | Article |
| id | doaj-art-42cc9abae22246e79def520b2f8fe331 |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-42cc9abae22246e79def520b2f8fe3312025-02-08T19:10:15ZengBMJ Publishing GroupRMD Open2056-59332016-09-012210.1136/rmdopen-2016-000279Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammationRoberta Ramonda0Leonardo Punzi1Anna Scanu2Francesca Oliviero3Roberto Luisetto4Paola Galozzi5Marta Favero6Rheumatology Unit, University of Padua, Padova, Veneto, Italy19 Department of Medicine, Ospedale SS Giovanni e Paolo Venezia, Venezia, Italy1University of Padova, Rheumatology Unit, Dept. of Medicine-DIMED, Padova, Italy1University of Padova, Rheumatology Unit, Dept. of Medicine-DIMED, Padova, Italy2University of Padova, Dept. of Surgical Oncological and Gastroenterological Sciences, Padova, Italy1University of Padova, Department of Medicine, Padova, Italy1Rheumatology Unit, University Hospital of Padova, Department of Medicine–DIMED, Padova, ItalyPost-traumatic arthritis (PTA) develops after an acute direct trauma to the joints. PTA causes about 12% of all osteoarthritis cases, and a history of physical trauma may also be found in patients with chronic inflammatory arthritis. Symptoms include swelling, synovial effusion, pain and sometimes intra-articular bleeding. Usually, PTA recoveries spontaneously, but the persistence of symptoms after 6 months may be considered pathological and so-called chronic PTA. A variety of molecular, mechanobiological and cellular events involved in the pathogenesis and the progression of PTA have been identified. The activation of inflammatory mechanisms during the PTA acute phase appears to play a critical role in the chronic disease onset. Human studies and experimental models have revealed that a series of inflammatory mediators are released in synovial fluid immediately after the joint trauma. These molecules have been proposed as markers of disease and as a potential target for the development of specific and preventative interventions. Currently, chronic PTA cannot be prevented, although a large number of agents have been tested in preclinical studies. Given the relevance of inflammatory reaction, anticytokines therapy, in particular the inhibition of interleukin 1 (IL-1), seems to be the most promising strategy. At the present time, intra-articular injection of IL-1 receptor antagonist is the only anticytokine approach that has been used in a human study of PTA. Despite the fact that knowledge in this area has increased in the past years, the identification of more specific disease markers and new therapeutic opportunities are needed.https://rmdopen.bmj.com/content/2/2/e000279.full |
| spellingShingle | Roberta Ramonda Leonardo Punzi Anna Scanu Francesca Oliviero Roberto Luisetto Paola Galozzi Marta Favero Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation RMD Open |
| title | Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation |
| title_full | Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation |
| title_fullStr | Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation |
| title_full_unstemmed | Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation |
| title_short | Post-traumatic arthritis: overview on pathogenic mechanisms and role of inflammation |
| title_sort | post traumatic arthritis overview on pathogenic mechanisms and role of inflammation |
| url | https://rmdopen.bmj.com/content/2/2/e000279.full |
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