Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production
Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulat...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/2543847 |
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| author | Ying Luo Quan-Neng Yan Wan-Zhou Wu Fan-Yan Luo |
| author_facet | Ying Luo Quan-Neng Yan Wan-Zhou Wu Fan-Yan Luo |
| author_sort | Ying Luo |
| collection | DOAJ |
| description | Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown. Here, we find that the migratory and proliferative capacities of circulating EPCs were decreased in patients with hypercholesterolemia versus normocholesterolemia. No significant differences were found between postmenopausal females and age-matched males. NO production showed positive correlation with the activity and count of circulating EPCs in patients with hypercholesterolemia. Flow-mediated dilatation (FMD) is directly interrelated with EPC counts and function. Our findings reveal that decreased EPC count and endothelial dysfunction lead to less NO production in hypercholesterolemic postmenopausal females. Maintaining the EPC numbers and activity might be emerging as a potential therapeutic strategy to reduce the risk of cardiovascular injury in elder women. |
| format | Article |
| id | doaj-art-42c2aea6e1fa4f1e98340adef599a930 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-42c2aea6e1fa4f1e98340adef599a9302025-02-03T01:21:54ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/25438472543847Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO ProductionYing Luo0Quan-Neng Yan1Wan-Zhou Wu2Fan-Yan Luo3Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410078, ChinaDepartment of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, ChinaDepartment of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410078, ChinaDepartment of Cardiothoracic Surgery, Xiangya Hospital, Central South University, Changsha 410078, ChinaEndothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown. Here, we find that the migratory and proliferative capacities of circulating EPCs were decreased in patients with hypercholesterolemia versus normocholesterolemia. No significant differences were found between postmenopausal females and age-matched males. NO production showed positive correlation with the activity and count of circulating EPCs in patients with hypercholesterolemia. Flow-mediated dilatation (FMD) is directly interrelated with EPC counts and function. Our findings reveal that decreased EPC count and endothelial dysfunction lead to less NO production in hypercholesterolemic postmenopausal females. Maintaining the EPC numbers and activity might be emerging as a potential therapeutic strategy to reduce the risk of cardiovascular injury in elder women.http://dx.doi.org/10.1155/2018/2543847 |
| spellingShingle | Ying Luo Quan-Neng Yan Wan-Zhou Wu Fan-Yan Luo Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production Stem Cells International |
| title | Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production |
| title_full | Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production |
| title_fullStr | Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production |
| title_full_unstemmed | Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production |
| title_short | Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production |
| title_sort | decreased count and dysfunction of circulating epcs in postmenopausal hypercholesterolemic females via reducing no production |
| url | http://dx.doi.org/10.1155/2018/2543847 |
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