Biochanin a modulates steroidogenesis and cellular metabolism in human granulosa cells through TAS2Rs activation: a spotlight on ovarian function

Biochanin a modulates steroidogenesis and cellular metabolism in human granulosa cells through TAS2Rs activation: a spotlight on ovarian function

Abstract Background Endocrine-disrupting chemicals (EDCs) interfere with the endocrine system and negatively impact reproductive health. Biochanin A (BCA), an isoflavone with anti-inflammatory and estrogen-like properties, has been identified as one such EDC. This study investigates the effects of B...

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Bibliographic Details
Main Authors: Francesca Paola Luongo, Sofia Passaponti, Alesandro Haxhiu, Irene Ortega Baño, Rosetta Ponchia, Giuseppe Morgante, Paola Piomboni, Alice Luddi
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Reproductive Biology and Endocrinology
Subjects:
EDCs
Granulosa cells
TAS2Rs
Steroidogenesis
Biochanin A
Mitochondria
Online Access:https://doi.org/10.1186/s12958-025-01344-9
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