Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus.
Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here, we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa following two independent introductions from South America. Through a combination of genome analyses and laboratory...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-04-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002052&type=printable |
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| author | Sergio M Latorre Vincent M Were Andrew J Foster Thorsten Langner Angus Malmgren Adeline Harant Soichiro Asuke Sarai Reyes-Avila Dipali Rani Gupta Cassandra Jensen Weibin Ma Nur Uddin Mahmud Md Shabab Mehebub Rabson M Mulenga Abu Naim Md Muzahid Sanjoy Kumar Paul S M Fajle Rabby Abdullah Al Mahbub Rahat Lauren Ryder Ram-Krishna Shrestha Suwilanji Sichilima Darren M Soanes Pawan Kumar Singh Alison R Bentley Diane G O Saunders Yukio Tosa Daniel Croll Kurt H Lamour Tofazzal Islam Batiseba Tembo Joe Win Nicholas J Talbot Hernán A Burbano Sophien Kamoun |
| author_facet | Sergio M Latorre Vincent M Were Andrew J Foster Thorsten Langner Angus Malmgren Adeline Harant Soichiro Asuke Sarai Reyes-Avila Dipali Rani Gupta Cassandra Jensen Weibin Ma Nur Uddin Mahmud Md Shabab Mehebub Rabson M Mulenga Abu Naim Md Muzahid Sanjoy Kumar Paul S M Fajle Rabby Abdullah Al Mahbub Rahat Lauren Ryder Ram-Krishna Shrestha Suwilanji Sichilima Darren M Soanes Pawan Kumar Singh Alison R Bentley Diane G O Saunders Yukio Tosa Daniel Croll Kurt H Lamour Tofazzal Islam Batiseba Tembo Joe Win Nicholas J Talbot Hernán A Burbano Sophien Kamoun |
| author_sort | Sergio M Latorre |
| collection | DOAJ |
| description | Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here, we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa following two independent introductions from South America. Through a combination of genome analyses and laboratory experiments, we show that the decade-old blast pandemic lineage can be controlled by the Rmg8 disease resistance gene and is sensitive to strobilurin fungicides. However, we also highlight the potential of the pandemic clone to evolve fungicide-insensitive variants and sexually recombine with African lineages. This underscores the urgent need for genomic surveillance to track and mitigate the spread of wheat blast outside of South America and to guide preemptive wheat breeding for blast resistance. |
| format | Article |
| id | doaj-art-42ba0a60d5f14762a2cfdc0086a6fdd0 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-42ba0a60d5f14762a2cfdc0086a6fdd02025-08-20T03:44:45ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-04-01214e300205210.1371/journal.pbio.3002052Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus.Sergio M LatorreVincent M WereAndrew J FosterThorsten LangnerAngus MalmgrenAdeline HarantSoichiro AsukeSarai Reyes-AvilaDipali Rani GuptaCassandra JensenWeibin MaNur Uddin MahmudMd Shabab MehebubRabson M MulengaAbu Naim Md MuzahidSanjoy Kumar PaulS M Fajle RabbyAbdullah Al Mahbub RahatLauren RyderRam-Krishna ShresthaSuwilanji SichilimaDarren M SoanesPawan Kumar SinghAlison R BentleyDiane G O SaundersYukio TosaDaniel CrollKurt H LamourTofazzal IslamBatiseba TemboJoe WinNicholas J TalbotHernán A BurbanoSophien KamounWheat, one of the most important food crops, is threatened by a blast disease pandemic. Here, we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa following two independent introductions from South America. Through a combination of genome analyses and laboratory experiments, we show that the decade-old blast pandemic lineage can be controlled by the Rmg8 disease resistance gene and is sensitive to strobilurin fungicides. However, we also highlight the potential of the pandemic clone to evolve fungicide-insensitive variants and sexually recombine with African lineages. This underscores the urgent need for genomic surveillance to track and mitigate the spread of wheat blast outside of South America and to guide preemptive wheat breeding for blast resistance.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002052&type=printable |
| spellingShingle | Sergio M Latorre Vincent M Were Andrew J Foster Thorsten Langner Angus Malmgren Adeline Harant Soichiro Asuke Sarai Reyes-Avila Dipali Rani Gupta Cassandra Jensen Weibin Ma Nur Uddin Mahmud Md Shabab Mehebub Rabson M Mulenga Abu Naim Md Muzahid Sanjoy Kumar Paul S M Fajle Rabby Abdullah Al Mahbub Rahat Lauren Ryder Ram-Krishna Shrestha Suwilanji Sichilima Darren M Soanes Pawan Kumar Singh Alison R Bentley Diane G O Saunders Yukio Tosa Daniel Croll Kurt H Lamour Tofazzal Islam Batiseba Tembo Joe Win Nicholas J Talbot Hernán A Burbano Sophien Kamoun Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus. PLoS Biology |
| title | Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus. |
| title_full | Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus. |
| title_fullStr | Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus. |
| title_full_unstemmed | Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus. |
| title_short | Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus. |
| title_sort | genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002052&type=printable |
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