Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain

Regulation of Rho guanine nucleotide exchange factor 3 by phosphorylation in the PH domain

Summary: Although most members of the Rho guanine nucleotide exchange factor (RhoGEF) family are found to be phosphorylated, how phosphorylation regulates RhoGEF function is poorly understood. Here we report the discovery of a mechanism of RhoGEF regulation by phosphorylation. We find that ARHGEF3 i...

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Bibliographic Details
Main Authors: Jesus F. Moreno, Jae-Sung You, Carlos C. Rodriguez, Shashank Pant, Adriana Reyes-Ordoñez, Reean Abdullah, Nilmani Singh, Maxine J. van der Donk, Emad Tajkhorshid, Jie Chen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Biochemistry
In silico biology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225010144
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