Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context
Summary: Background: We apply endoscopic ultrasound-guided fine needle aspiration biopsy to cytopathologically diagnose and sample nucleic acids from primary tumours regardless of the disease stage. Methods: 397 patients with proven pancreatic adenocarcinoma were included and followed up in a multi...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
|
| Series: | EBioMedicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396424004092 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850192049041571840 |
|---|---|
| author | Rémy Nicolle Cindy Canivet Laurent Palazzo Bertrand Napoléon Mira Ayadi Camille Pignolet Jérôme Cros Sophie Gourgou Janick Selves Jérôme Torrisani Nelson Dusetti Pierre Cordelier Louis Buscail Barbara Bournet Barbara Bournet Cindy Canivet Louis Buscail Nicolas Carrère Fabrice Muscari Bertrand Suc Rosine Guimbaud Corinne Couteau Marion Deslandres Pascale Rivera Emily Alouany Nadim Fares Karl Barange Janick Selves Anne Gomez-Brouchet Adrian Culetto Guillaume Le Cosquer Marion Jaffrelot Bertrand Napoléon Bertrand Pujol Fabien Fumex Jérôme Desrame Christine Lefort Vincent Lepilliez Rodica Gincul Pascal Artru Léa Clavel Anne-Isabelle Lemaistre Laurent Palazzo Jérôme Cros Sarah Tubiana Nicolas Flori Pierre Senesse Pierre-Emmanuel Colombo Emmanuelle Samalin-Scalzi Fabienne Portales Sophie Gourgou Lise Roca Claire Honfo Ga Carinne Plassot Marc Ychou Pierre Guibert Christelle De La Fouchardière Mathieu Sarabi Patrice Peyrat Séverine Tabone-Eglinger Caroline Renard Guillaume Piessen Stéphanie Truant Alain Saudemont Guillaume Millet Florence Renaud Emmanuelle Leteurtre Patrick Gelé Eric Assenat Jean-Michel Fabre François-Régis Souche Marie Dupuy Anne-Marie Gorce-Dupuy Jeanne Ramos Jean-François Seitz Jean Hardwigsen Emmanuelle Norguet-Monnereau Philippe Grandval Muriel Duluc Dominique Figarella-Branger Véronique Vendrely Clément Subtil Eric Terrebonne Jean-Frédéric Blanc Jean-Philippe Merlio Dominique Farges-Bancel Jean-Marc Gornet Daniela Geromin Geoffroy Vanbiervliet Anne-Claire Frin Delphine Ouvrier Marie-Christine Saint-Paul Philippe Berthélémy Chelbabi Fouad Stéphane Garcia Nathalie Lesavre Mohamed Gasmi Marc Barthet Vanessa Cottet Cyrille Delpierre |
| author_facet | Rémy Nicolle Cindy Canivet Laurent Palazzo Bertrand Napoléon Mira Ayadi Camille Pignolet Jérôme Cros Sophie Gourgou Janick Selves Jérôme Torrisani Nelson Dusetti Pierre Cordelier Louis Buscail Barbara Bournet Barbara Bournet Cindy Canivet Louis Buscail Nicolas Carrère Fabrice Muscari Bertrand Suc Rosine Guimbaud Corinne Couteau Marion Deslandres Pascale Rivera Emily Alouany Nadim Fares Karl Barange Janick Selves Anne Gomez-Brouchet Adrian Culetto Guillaume Le Cosquer Marion Jaffrelot Bertrand Napoléon Bertrand Pujol Fabien Fumex Jérôme Desrame Christine Lefort Vincent Lepilliez Rodica Gincul Pascal Artru Léa Clavel Anne-Isabelle Lemaistre Laurent Palazzo Jérôme Cros Sarah Tubiana Nicolas Flori Pierre Senesse Pierre-Emmanuel Colombo Emmanuelle Samalin-Scalzi Fabienne Portales Sophie Gourgou Lise Roca Claire Honfo Ga Carinne Plassot Marc Ychou Pierre Guibert Christelle De La Fouchardière Mathieu Sarabi Patrice Peyrat Séverine Tabone-Eglinger Caroline Renard Guillaume Piessen Stéphanie Truant Alain Saudemont Guillaume Millet Florence Renaud Emmanuelle Leteurtre Patrick Gelé Eric Assenat Jean-Michel Fabre François-Régis Souche Marie Dupuy Anne-Marie Gorce-Dupuy Jeanne Ramos Jean-François Seitz Jean Hardwigsen Emmanuelle Norguet-Monnereau Philippe Grandval Muriel Duluc Dominique Figarella-Branger Véronique Vendrely Clément Subtil Eric Terrebonne Jean-Frédéric Blanc Jean-Philippe Merlio Dominique Farges-Bancel Jean-Marc Gornet Daniela Geromin Geoffroy Vanbiervliet Anne-Claire Frin Delphine Ouvrier Marie-Christine Saint-Paul Philippe Berthélémy Chelbabi Fouad Stéphane Garcia Nathalie Lesavre Mohamed Gasmi Marc Barthet Vanessa Cottet Cyrille Delpierre |
| author_sort | Rémy Nicolle |
| collection | DOAJ |
| description | Summary: Background: We apply endoscopic ultrasound-guided fine needle aspiration biopsy to cytopathologically diagnose and sample nucleic acids from primary tumours regardless of the disease stage. Methods: 397 patients with proven pancreatic adenocarcinoma were included and followed up in a multicentre prospective study. DNA and mRNA were extracted from materials of primary tumours obtained by endoscopic ultrasound-guided fine needle aspiration biopsy and analysed using targeted deep sequencing and RNAseq respectively. Findings: The variant allele frequency of the KRAS mutation was used to evaluate the tumour cellularity, ranging from 15 to 20% in all cells, regardless of the tumour stage. The molecular profile of metastatic primary tumours significantly differed from other types of tumours, more frequently having TP53 mutations (p = 0.0002), less frequently having RNF43 mutations, and possessing more basal-like mRNA component (p = 0.001). Molecular markers associated with improved overall survival were: mutations in homologous recombination deficiency genes in patients who received first-line platinum-based chemotherapy (p = 0.025) and wild-type TP53 gene in patients with locally advanced tumours who received radio-chemotherapy (p = 0.01). The GemPred transcriptomic profile was associated with a significantly better overall survival in patients with locally advanced or metastatic pancreatic cancer who received a gemcitabine-based first-line treatment (p = 0.019). Interpretation: The combination of genomic and transcriptomic analyses of primary pancreatic tumours enables us to distinguish metastatic tumours from other tumour types. Our molecular strategy may assist in predicting overall survival outcomes for platinum or gemcitabine-based chemotherapies, as well as radio-chemotherapy. Funding: Institut National Du Cancer (BCB INCa_7294), CHU of Toulouse, Inserm and Ligue Nationale Contre le Cancer (CIT program). |
| format | Article |
| id | doaj-art-42b1e90f321d4eb681ad93fd73b2d3f5 |
| institution | OA Journals |
| issn | 2352-3964 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj-art-42b1e90f321d4eb681ad93fd73b2d3f52025-08-20T02:14:42ZengElsevierEBioMedicine2352-39642024-11-0110910537310.1016/j.ebiom.2024.105373Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in contextRémy Nicolle0Cindy Canivet1Laurent Palazzo2Bertrand Napoléon3Mira Ayadi4Camille Pignolet5Jérôme Cros6Sophie Gourgou7Janick Selves8Jérôme Torrisani9Nelson Dusetti10Pierre Cordelier11Louis Buscail12Barbara Bournet13Barbara BournetCindy CanivetLouis BuscailNicolas CarrèreFabrice MuscariBertrand SucRosine GuimbaudCorinne CouteauMarion DeslandresPascale RiveraEmily AlouanyNadim FaresKarl BarangeJanick SelvesAnne Gomez-BrouchetAdrian CulettoGuillaume Le CosquerMarion JaffrelotBertrand NapoléonBertrand PujolFabien FumexJérôme DesrameChristine LefortVincent LepilliezRodica GinculPascal ArtruLéa ClavelAnne-Isabelle LemaistreLaurent PalazzoJérôme CrosSarah TubianaNicolas FloriPierre SenessePierre-Emmanuel ColomboEmmanuelle Samalin-ScalziFabienne PortalesSophie GourgouLise RocaClaire Honfo GaCarinne PlassotMarc YchouPierre GuibertChristelle De La FouchardièreMathieu SarabiPatrice PeyratSéverine Tabone-EglingerCaroline RenardGuillaume PiessenStéphanie TruantAlain SaudemontGuillaume MilletFlorence RenaudEmmanuelle LeteurtrePatrick GeléEric AssenatJean-Michel FabreFrançois-Régis SoucheMarie DupuyAnne-Marie Gorce-DupuyJeanne RamosJean-François SeitzJean HardwigsenEmmanuelle Norguet-MonnereauPhilippe GrandvalMuriel DulucDominique Figarella-BrangerVéronique VendrelyClément SubtilEric TerrebonneJean-Frédéric BlancJean-Philippe MerlioDominique Farges-BancelJean-Marc GornetDaniela GerominGeoffroy VanbiervlietAnne-Claire FrinDelphine OuvrierMarie-Christine Saint-PaulPhilippe BerthélémyChelbabi FouadStéphane GarciaNathalie LesavreMohamed GasmiMarc BarthetVanessa CottetCyrille DelpierreUniversité Paris Cité, Centre de Recherche sur l’Inflammation (CRI), INSERM, U1149, CNRS, ERL 8252, Paris F-75018, FranceService de Gastroentérologie et Pancréatologie, Centre Hospitalier Universitaire de Toulouse-Rangueil (CHU), Toulouse, FranceService d’Endoscopie, Clinique du Trocadéro, Paris, FranceService de Gastroentérologie, Hôpital Privé Jean Mermoz, Ramsay Générale de Santé, Lyon, FranceProgramme Cartes d’Identité des Tumeurs, Ligue Nationale Contre Le Cancer, Paris, FranceUniversité Paris Cité, Centre de Recherche sur l’Inflammation (CRI), INSERM, U1149, CNRS, ERL 8252, Paris F-75018, FranceUniversité Paris Cité, Centre de Recherche sur l’Inflammation (CRI), INSERM, U1149, CNRS, ERL 8252, Paris F-75018, France; Université Paris Cité, Service d’Anatomopathologie, Centre Hospitalier Universitaire Beaujon/Bichat (APHP), Clichy/Paris, FranceInstitut du Cancer de Montpellier-Val d’Aurelle, Université de Montpellier, Montpellier, FranceService d’Anatomopathologie, Institut Universitaire du Cancer-Oncopole de Toulouse, Centre Hospitalier Universitaire (CHU), Toulouse, FranceCentre de Recherches en Cancérologie de Toulouse, Inserm U1037, CRCT, Université de Toulouse, Inserm, CNRS, Toulouse, FranceCentre de Recherche sur le Cancer de Marseille, Inserm, CNRS, Institut Paoli-Calmettes, Université Aix-Marseille, Marseille, FranceCentre de Recherches en Cancérologie de Toulouse, Inserm U1037, CRCT, Université de Toulouse, Inserm, CNRS, Toulouse, FranceService de Gastroentérologie et Pancréatologie, Centre Hospitalier Universitaire de Toulouse-Rangueil (CHU), Toulouse, France; Centre de Recherches en Cancérologie de Toulouse, Inserm U1037, CRCT, Université de Toulouse, Inserm, CNRS, Toulouse, France; Corresponding author. Service de Gastroentérologie et Pancréatologie, Centre Hospitalier Universitaire de Toulouse-Rangueil (CHU), 1 avenue Jean Poulhès, TSA 50032, 31059 Toulouse cedex 9, France.Service de Gastroentérologie et Pancréatologie, Centre Hospitalier Universitaire de Toulouse-Rangueil (CHU), Toulouse, France; Centre de Recherches en Cancérologie de Toulouse, Inserm U1037, CRCT, Université de Toulouse, Inserm, CNRS, Toulouse, FranceSummary: Background: We apply endoscopic ultrasound-guided fine needle aspiration biopsy to cytopathologically diagnose and sample nucleic acids from primary tumours regardless of the disease stage. Methods: 397 patients with proven pancreatic adenocarcinoma were included and followed up in a multicentre prospective study. DNA and mRNA were extracted from materials of primary tumours obtained by endoscopic ultrasound-guided fine needle aspiration biopsy and analysed using targeted deep sequencing and RNAseq respectively. Findings: The variant allele frequency of the KRAS mutation was used to evaluate the tumour cellularity, ranging from 15 to 20% in all cells, regardless of the tumour stage. The molecular profile of metastatic primary tumours significantly differed from other types of tumours, more frequently having TP53 mutations (p = 0.0002), less frequently having RNF43 mutations, and possessing more basal-like mRNA component (p = 0.001). Molecular markers associated with improved overall survival were: mutations in homologous recombination deficiency genes in patients who received first-line platinum-based chemotherapy (p = 0.025) and wild-type TP53 gene in patients with locally advanced tumours who received radio-chemotherapy (p = 0.01). The GemPred transcriptomic profile was associated with a significantly better overall survival in patients with locally advanced or metastatic pancreatic cancer who received a gemcitabine-based first-line treatment (p = 0.019). Interpretation: The combination of genomic and transcriptomic analyses of primary pancreatic tumours enables us to distinguish metastatic tumours from other tumour types. Our molecular strategy may assist in predicting overall survival outcomes for platinum or gemcitabine-based chemotherapies, as well as radio-chemotherapy. Funding: Institut National Du Cancer (BCB INCa_7294), CHU of Toulouse, Inserm and Ligue Nationale Contre le Cancer (CIT program).http://www.sciencedirect.com/science/article/pii/S2352396424004092Pancreatic cancerRNA sequencingTargeted DNA deep sequencingTranslational medicinePredictive medicine |
| spellingShingle | Rémy Nicolle Cindy Canivet Laurent Palazzo Bertrand Napoléon Mira Ayadi Camille Pignolet Jérôme Cros Sophie Gourgou Janick Selves Jérôme Torrisani Nelson Dusetti Pierre Cordelier Louis Buscail Barbara Bournet Barbara Bournet Cindy Canivet Louis Buscail Nicolas Carrère Fabrice Muscari Bertrand Suc Rosine Guimbaud Corinne Couteau Marion Deslandres Pascale Rivera Emily Alouany Nadim Fares Karl Barange Janick Selves Anne Gomez-Brouchet Adrian Culetto Guillaume Le Cosquer Marion Jaffrelot Bertrand Napoléon Bertrand Pujol Fabien Fumex Jérôme Desrame Christine Lefort Vincent Lepilliez Rodica Gincul Pascal Artru Léa Clavel Anne-Isabelle Lemaistre Laurent Palazzo Jérôme Cros Sarah Tubiana Nicolas Flori Pierre Senesse Pierre-Emmanuel Colombo Emmanuelle Samalin-Scalzi Fabienne Portales Sophie Gourgou Lise Roca Claire Honfo Ga Carinne Plassot Marc Ychou Pierre Guibert Christelle De La Fouchardière Mathieu Sarabi Patrice Peyrat Séverine Tabone-Eglinger Caroline Renard Guillaume Piessen Stéphanie Truant Alain Saudemont Guillaume Millet Florence Renaud Emmanuelle Leteurtre Patrick Gelé Eric Assenat Jean-Michel Fabre François-Régis Souche Marie Dupuy Anne-Marie Gorce-Dupuy Jeanne Ramos Jean-François Seitz Jean Hardwigsen Emmanuelle Norguet-Monnereau Philippe Grandval Muriel Duluc Dominique Figarella-Branger Véronique Vendrely Clément Subtil Eric Terrebonne Jean-Frédéric Blanc Jean-Philippe Merlio Dominique Farges-Bancel Jean-Marc Gornet Daniela Geromin Geoffroy Vanbiervliet Anne-Claire Frin Delphine Ouvrier Marie-Christine Saint-Paul Philippe Berthélémy Chelbabi Fouad Stéphane Garcia Nathalie Lesavre Mohamed Gasmi Marc Barthet Vanessa Cottet Cyrille Delpierre Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context EBioMedicine Pancreatic cancer RNA sequencing Targeted DNA deep sequencing Translational medicine Predictive medicine |
| title | Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context |
| title_full | Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context |
| title_fullStr | Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context |
| title_full_unstemmed | Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context |
| title_short | Predictive genomic and transcriptomic analysis on endoscopic ultrasound-guided fine needle aspiration materials from primary pancreatic adenocarcinoma: a prospective multicentre studyResearch in context |
| title_sort | predictive genomic and transcriptomic analysis on endoscopic ultrasound guided fine needle aspiration materials from primary pancreatic adenocarcinoma a prospective multicentre studyresearch in context |
| topic | Pancreatic cancer RNA sequencing Targeted DNA deep sequencing Translational medicine Predictive medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2352396424004092 |
| work_keys_str_mv | AT remynicolle predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT cindycanivet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT laurentpalazzo predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT bertrandnapoleon predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT miraayadi predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT camillepignolet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeromecros predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT sophiegourgou predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT janickselves predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jerometorrisani predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT nelsondusetti predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT pierrecordelier predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT louisbuscail predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT barbarabournet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT barbarabournet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT cindycanivet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT louisbuscail predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT nicolascarrere predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT fabricemuscari predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT bertrandsuc predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT rosineguimbaud predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT corinnecouteau predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT mariondeslandres predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT pascalerivera predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT emilyalouany predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT nadimfares predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT karlbarange predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT janickselves predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT annegomezbrouchet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT adrianculetto predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT guillaumelecosquer predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT marionjaffrelot predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT bertrandnapoleon predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT bertrandpujol predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT fabienfumex predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeromedesrame predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT christinelefort predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT vincentlepilliez predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT rodicagincul predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT pascalartru predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT leaclavel predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT anneisabellelemaistre predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT laurentpalazzo predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeromecros predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT sarahtubiana predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT nicolasflori predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT pierresenesse predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT pierreemmanuelcolombo predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT emmanuellesamalinscalzi predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT fabienneportales predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT sophiegourgou predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT liseroca predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT clairehonfoga predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT carinneplassot predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT marcychou predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT pierreguibert predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT christelledelafouchardiere predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT mathieusarabi predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT patricepeyrat predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT severinetaboneeglinger predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT carolinerenard predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT guillaumepiessen predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT stephanietruant predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT alainsaudemont predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT guillaumemillet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT florencerenaud predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT emmanuelleleteurtre predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT patrickgele predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT ericassenat predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeanmichelfabre predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT francoisregissouche predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT mariedupuy predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT annemariegorcedupuy predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeanneramos predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeanfrancoisseitz predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeanhardwigsen predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT emmanuellenorguetmonnereau predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT philippegrandval predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT murielduluc predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT dominiquefigarellabranger predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT veroniquevendrely predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT clementsubtil predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT ericterrebonne predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeanfredericblanc predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeanphilippemerlio predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT dominiquefargesbancel predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT jeanmarcgornet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT danielageromin predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT geoffroyvanbiervliet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT anneclairefrin predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT delphineouvrier predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT mariechristinesaintpaul predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT philippeberthelemy predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT chelbabifouad predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT stephanegarcia predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT nathalielesavre predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT mohamedgasmi predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT marcbarthet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT vanessacottet predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext AT cyrilledelpierre predictivegenomicandtranscriptomicanalysisonendoscopicultrasoundguidedfineneedleaspirationmaterialsfromprimarypancreaticadenocarcinomaaprospectivemulticentrestudyresearchincontext |