Clinic-morphological characteristics of Cryptococcosis in HIV-infective patients
The present article contains the results of observation for 8 generalized cryptococcosis patients with HIVinfection. The disease occurred in the presence of strongly marked immunodeficiency (the reduction of CD-4 lymphocytes less than 100 cells/mkl) in generalized form with the damage of central ner...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/135 |
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| author | I. P. Charushina N. V. Zotova |
| author_facet | I. P. Charushina N. V. Zotova |
| author_sort | I. P. Charushina |
| collection | DOAJ |
| description | The present article contains the results of observation for 8 generalized cryptococcosis patients with HIVinfection. The disease occurred in the presence of strongly marked immunodeficiency (the reduction of CD-4 lymphocytes less than 100 cells/mkl) in generalized form with the damage of central nervous system and without any clinical features of internal disturbances. The disease was characterized by severe progressing course of the infection which led to lethal outcome in 5 cases. Pathomorphological appearance was presented by multiple necrotic focuses with cryptococcus accumulation in brain, lungs, liver, lien, lymphatic nodes, intestines. Early complex diagnosis including obligatory mycological examination of liquor and other pathological material and timely added adequate antimycotic therapy are obligatory conditions for effective treatment of cryptococcosis. The clinical example of effective treatment of invasive cryptococcosispresented. |
| format | Article |
| id | doaj-art-42b1d7dfc8d34784a2e7fb51d36dc4c8 |
| institution | DOAJ |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-42b1d7dfc8d34784a2e7fb51d36dc4c82025-08-20T03:22:15ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0144657010.22625/2072-6732-2012-4-4-65-70149Clinic-morphological characteristics of Cryptococcosis in HIV-infective patientsI. P. Charushina0N. V. Zotova1Perm State Medical Academy named after academic E.A. Vagner, PermTerritory Clinical Infectious Diseases Hospital, PermThe present article contains the results of observation for 8 generalized cryptococcosis patients with HIVinfection. The disease occurred in the presence of strongly marked immunodeficiency (the reduction of CD-4 lymphocytes less than 100 cells/mkl) in generalized form with the damage of central nervous system and without any clinical features of internal disturbances. The disease was characterized by severe progressing course of the infection which led to lethal outcome in 5 cases. Pathomorphological appearance was presented by multiple necrotic focuses with cryptococcus accumulation in brain, lungs, liver, lien, lymphatic nodes, intestines. Early complex diagnosis including obligatory mycological examination of liquor and other pathological material and timely added adequate antimycotic therapy are obligatory conditions for effective treatment of cryptococcosis. The clinical example of effective treatment of invasive cryptococcosispresented.https://journal.niidi.ru/jofin/article/view/135cryptococcus neoformansinvasive cryptococcosishiv-infectionmeningocephalitisamphotericin b |
| spellingShingle | I. P. Charushina N. V. Zotova Clinic-morphological characteristics of Cryptococcosis in HIV-infective patients Журнал инфектологии cryptococcus neoformans invasive cryptococcosis hiv-infection meningocephalitis amphotericin b |
| title | Clinic-morphological characteristics of Cryptococcosis in HIV-infective patients |
| title_full | Clinic-morphological characteristics of Cryptococcosis in HIV-infective patients |
| title_fullStr | Clinic-morphological characteristics of Cryptococcosis in HIV-infective patients |
| title_full_unstemmed | Clinic-morphological characteristics of Cryptococcosis in HIV-infective patients |
| title_short | Clinic-morphological characteristics of Cryptococcosis in HIV-infective patients |
| title_sort | clinic morphological characteristics of cryptococcosis in hiv infective patients |
| topic | cryptococcus neoformans invasive cryptococcosis hiv-infection meningocephalitis amphotericin b |
| url | https://journal.niidi.ru/jofin/article/view/135 |
| work_keys_str_mv | AT ipcharushina clinicmorphologicalcharacteristicsofcryptococcosisinhivinfectivepatients AT nvzotova clinicmorphologicalcharacteristicsofcryptococcosisinhivinfectivepatients |