Neurobiological intersections of stress and substance use disorders
Substance use has been intertwined with human history for millennia. Throughout the ages, people have consumed various substances for medicinal, spiritual, and recreational reasons, although occasional use differs significantly from substance use disorders (SUDs). Exposure to lifetime stressors cons...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1548372/full |
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| author | Vitor Augusto Laurino Juliano Kairo Alan Albernaz-Mariano Luiza Helena Halas Covre Paloma Marinho Jucá Robbert Mota Pereira Amadeu Shigeo-de-Almeida Lucas Luzia Sampaio Erica de Almeida Duque Carolina Demarchi Munhoz |
| author_facet | Vitor Augusto Laurino Juliano Kairo Alan Albernaz-Mariano Luiza Helena Halas Covre Paloma Marinho Jucá Robbert Mota Pereira Amadeu Shigeo-de-Almeida Lucas Luzia Sampaio Erica de Almeida Duque Carolina Demarchi Munhoz |
| author_sort | Vitor Augusto Laurino Juliano |
| collection | DOAJ |
| description | Substance use has been intertwined with human history for millennia. Throughout the ages, people have consumed various substances for medicinal, spiritual, and recreational reasons, although occasional use differs significantly from substance use disorders (SUDs). Exposure to lifetime stressors constitutes a significant risk factor for both psychiatric disorders and SUD development and relapse. Indeed, hypothalamic–pituitary–adrenal (HPA) axis modulation, alterations in neuroanatomical and neurotransmitter systems, as well as neuroinflammation are common features of stress-related mood disorders and SUDs. In this mini-review, we will explore how stress exposure influences the SUDs' neurobiological basis on different scales—from large neural circuitries to specific molecular mechanisms—and discuss novel targets for potential treatments. |
| format | Article |
| id | doaj-art-42b08b28bcf444a48c1fd16018355e1e |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-42b08b28bcf444a48c1fd16018355e1e2025-08-20T02:55:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-05-011910.3389/fnins.2025.15483721548372Neurobiological intersections of stress and substance use disordersVitor Augusto Laurino JulianoKairo Alan Albernaz-MarianoLuiza Helena Halas CovrePaloma Marinho JucáRobbert Mota PereiraAmadeu Shigeo-de-AlmeidaLucas Luzia SampaioErica de Almeida DuqueCarolina Demarchi MunhozSubstance use has been intertwined with human history for millennia. Throughout the ages, people have consumed various substances for medicinal, spiritual, and recreational reasons, although occasional use differs significantly from substance use disorders (SUDs). Exposure to lifetime stressors constitutes a significant risk factor for both psychiatric disorders and SUD development and relapse. Indeed, hypothalamic–pituitary–adrenal (HPA) axis modulation, alterations in neuroanatomical and neurotransmitter systems, as well as neuroinflammation are common features of stress-related mood disorders and SUDs. In this mini-review, we will explore how stress exposure influences the SUDs' neurobiological basis on different scales—from large neural circuitries to specific molecular mechanisms—and discuss novel targets for potential treatments.https://www.frontiersin.org/articles/10.3389/fnins.2025.1548372/fullHPA axisneuroinflammationmood disordersearly life stresssubstance use disorder |
| spellingShingle | Vitor Augusto Laurino Juliano Kairo Alan Albernaz-Mariano Luiza Helena Halas Covre Paloma Marinho Jucá Robbert Mota Pereira Amadeu Shigeo-de-Almeida Lucas Luzia Sampaio Erica de Almeida Duque Carolina Demarchi Munhoz Neurobiological intersections of stress and substance use disorders Frontiers in Neuroscience HPA axis neuroinflammation mood disorders early life stress substance use disorder |
| title | Neurobiological intersections of stress and substance use disorders |
| title_full | Neurobiological intersections of stress and substance use disorders |
| title_fullStr | Neurobiological intersections of stress and substance use disorders |
| title_full_unstemmed | Neurobiological intersections of stress and substance use disorders |
| title_short | Neurobiological intersections of stress and substance use disorders |
| title_sort | neurobiological intersections of stress and substance use disorders |
| topic | HPA axis neuroinflammation mood disorders early life stress substance use disorder |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1548372/full |
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