Intratumoral/Peritumoral Herpes Simplex Virus-1 Mutant HSV1716 in Pediatric Patients with Refractory or Recurrent High-Grade Gliomas: A Report of the Pediatric Brain Tumor Consortium

Intratumoral/Peritumoral Herpes Simplex Virus-1 Mutant HSV1716 in Pediatric Patients with Refractory or Recurrent High-Grade Gliomas: A Report of the Pediatric Brain Tumor Consortium

Background/Objectives: Multiple immune-modulatory strategies have been tested in efforts to mitigate the pro-tumor microenvironment in pediatric high-grade glioma. HSV1716 is an oncolytic virus that previously demonstrated evidence of response in adult and pediatric patients. PBTC-037 was a single-c...

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Bibliographic Details
Main Authors: Aaron Y. Mochizuki, Trent R. Hummel, Timothy Cripe, Maryam Fouladi, Ian F. Pollack, Duane Mitchell, Tina Young Poussaint, Arzu Onar-Thomas, Natasha Pillay-Smiley, Mariko DeWire-Schottmiller, Charles B. Stevenson
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Onco
Subjects:
pediatric high-grade glioma
immunovirotherapy
oncolytic virus
Online Access:https://www.mdpi.com/2673-7523/5/1/1
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