Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A Review
The depletion of superoxide catalyzed by human manganese superoxide dismutase (MnSOD) was observed spectrophotometrically by measuring the absorbance of superoxide at 250-280 nm following pulse radiolysis and it showed a biphasic pattern. Tryptophan 161 is a highly conserved residue that forms a hyd...
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| Language: | English |
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Hammer Head Production Limited
2016-07-01
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| Series: | Sokoto Journal of Medical Laboratory Science |
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| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/369 |
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| author | Alhassan A. J.*, Muhammad, I. U., Sule, M.S, Adamu, S.M. and Umar, Y. |
| author_facet | Alhassan A. J.*, Muhammad, I. U., Sule, M.S, Adamu, S.M. and Umar, Y. |
| author_sort | Alhassan A. J.*, Muhammad, I. U., Sule, M.S, Adamu, S.M. and Umar, Y. |
| collection | DOAJ |
| description | The depletion of superoxide catalyzed by human manganese superoxide dismutase (MnSOD) was observed spectrophotometrically by measuring the absorbance of superoxide at 250-280 nm following pulse radiolysis and it showed a biphasic pattern. Tryptophan 161 is a highly conserved residue that forms a hydrophobic side of the active site cavity of manganese superoxide dismutase (MnSOD), with its indole ring adjacent to and about 5 Å from the manganese. Trp 161 promotes the dissociation of product peroxide, perhaps in part through its effect on the orientation of Tyr 34. |
| format | Article |
| id | doaj-art-42ab22f1007d4903ae49e113e143f9db |
| institution | DOAJ |
| issn | 2536-7153 |
| language | English |
| publishDate | 2016-07-01 |
| publisher | Hammer Head Production Limited |
| record_format | Article |
| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-42ab22f1007d4903ae49e113e143f9db2025-08-20T02:52:05ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532016-07-0111369Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A ReviewAlhassan A. J.*, Muhammad, I. U., Sule, M.S, Adamu, S.M. and Umar, Y.The depletion of superoxide catalyzed by human manganese superoxide dismutase (MnSOD) was observed spectrophotometrically by measuring the absorbance of superoxide at 250-280 nm following pulse radiolysis and it showed a biphasic pattern. Tryptophan 161 is a highly conserved residue that forms a hydrophobic side of the active site cavity of manganese superoxide dismutase (MnSOD), with its indole ring adjacent to and about 5 Å from the manganese. Trp 161 promotes the dissociation of product peroxide, perhaps in part through its effect on the orientation of Tyr 34.https://sokjmls.com.ng/index.php/SJMLS/article/view/369manganese, pulse radiolysis, superoxide dismutase, tryptophan |
| spellingShingle | Alhassan A. J.*, Muhammad, I. U., Sule, M.S, Adamu, S.M. and Umar, Y. Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A Review Sokoto Journal of Medical Laboratory Science manganese, pulse radiolysis, superoxide dismutase, tryptophan |
| title | Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A Review |
| title_full | Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A Review |
| title_fullStr | Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A Review |
| title_full_unstemmed | Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A Review |
| title_short | Pulse Radiolysis Study of Catalytic Properties of Human Manganese Superoxide Dismutase: A Review |
| title_sort | pulse radiolysis study of catalytic properties of human manganese superoxide dismutase a review |
| topic | manganese, pulse radiolysis, superoxide dismutase, tryptophan |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/369 |
| work_keys_str_mv | AT alhassanajmuhammadiusulemsadamusmandumary pulseradiolysisstudyofcatalyticpropertiesofhumanmanganesesuperoxidedismutaseareview |